(S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran

ChemicalBook > CAS DataBase List > (S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran

(S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran

Physical Form Uses

Product Name: (S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran
CAS No.: 915095-94-2
Chemical Name: (S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran
Synonyms: EMpagliflozin iMpurity C;(S)-4-iodo-1-chloro-2-(4-tetrahydrofuran-3-yloxy-benzyl)-benzene;]phenoxy}oxoL;oro-5-iodophenyL;(3S)-3-{4-[(2-chL;Englitin Impurity 28;Empagliflozin Impurity 110;Empagliflozin Intermediate1;(3S)-3-[4-[(2-Chloro-5-iodophenyl) methyl] phenc;1-chloro-2-(4-(cyclopentyloxy)benzyl)-4-iodobenzene
CBNumber: CB12657939
Molecular Formula: C17H16ClIO2
Formula Weight: 414.67
MOL File: 915095-94-2.mol

Less

(S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran Property

Boiling point:: 476.0±45.0 °C(Predicted)
Density: 1.578±0.06 g/cm3 (20 ºC 760 Torr)
storage temp.: 2-8°C(protect from light)
solubility: DMSO, Methanol (Slightly, Sonicated)
form: Solid
color: White to Off-White
InChI: InChI=1S/C17H16ClIO2/c18-17-6-3-14(19)10-13(17)9-12-1-4-15(5-2-12)21-16-7-8-20-11-16/h1-6,10,16H,7-9,11H2/t16-/m0/s1
InChIKey: YLUHNGIWRCCQMQ-INIZCTEOSA-N
SMILES: O1CC[C@H](OC2=CC=C(CC3=CC(I)=CC=C3Cl)C=C2)C1
CAS DataBase Reference: 915095-94-2

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Less

N-Bromosuccinimide Price

AK Scientific

Product number: 9598AF
Product name: (3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan
Packaging: 1g
Price: $39
Updated: 2021/12/16

AK Scientific

Product number: J95043
Product name: (3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan
Packaging: 5g
Price: $88
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2H10-M-S0
Product name: (3S)-3-{4-[(2-Chloro-5-iodophenyl)methyl]phenoxy}oxolane
Purity: 97.0%
Packaging: 250mg
Price: $115
Updated: 2021/12/16

AK Scientific

Product number: 9598AF
Product name: (3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan
Packaging: 5g
Price: $118
Updated: 2021/12/16

AK Scientific

Product number: 9598AF
Product name: (3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan
Packaging: 10g
Price: $189
Updated: 2021/12/16

Less

(S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran Chemical Properties,Usage,Production

Physical Form

Solid

Uses

(3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran(915095-94-2) can be used as reactant/reagent in preparation of C-?aryl D-?glurofuranoside compounds useful as reference compounds in the quality control of gliflozin type medicine.

Description

(S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran is a pharmaceutical intermediate compound that is used in the preparation of empagliflozin. Empagliflozin is an inhibitor of sodium-glucose co-transporter protein-2 (SGLT2), which is used in the treatment of type 2 diabetes.

Preparation

0.5 mol of (S)-(2-chloro-5-iodophenyl)(4-((tetrahydrofuran-3-yl)oxy)phenyl)methanone and 0.6 mol of aluminum chloride were added to 2 mol of methanol at a temperature of 20° C, and then 0.6 mol of triethylsilane was added to the mixed solution. The mixture was stirred at 25° C for 1 h.The conversion is determined by HPLC analysis. After the reaction is complete, it is extracted and distilled under reduced pressure.Finally, (3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan (also known as (S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran) was obtained through purification.

(S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran Preparation Products And Raw materials

Raw materials

Preparation Products

Less

(S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran Suppliers

Canada 1 China 354 Germany 1 India 17 United Kingdom 1 United States 7 Global 381

Jinan Dexinjia Bio&Tech Co., Ltd

Tel: 0531-82375886 13001715031
Fax: 0531-82375893
Email: 3517280075@qq.com
Country: China
ProdList: 1306
Advantage: 58

PharmaHands (Taizhou) Co., Ltd.

Tel: 0523-86200360 18994667002
Fax: 0523-86200350
Email: sales@pharmahands.com.cn
Country: China
ProdList: 34
Advantage: 60

Jiangsu Vcare PharmaTech Co., Ltd.

Tel: 13327700685
Fax: +86-25-58744115
Email: sales@vcarepharmatech.com
Country: China
ProdList: 310
Advantage: 61

Abydos Scientific

Tel: 025-84767922 18936879710
Email: sales@abydoscientific.com
Country: China
ProdList: 1006
Advantage: 58

HSDK（Nanjing）Pharma Tech Co.，Ltd.

Tel: 15189849794
Email: xiaojin.wu@hsdk-pharmatech.cn
Country: China
ProdList: 25
Advantage: 58

Aobolihui

Tel: 0917-18691729 18691729963
Email: 2553382659@qq.com
Country: China
ProdList: 4747
Advantage: 58

Shandong Zhongke Taidou Chemical Co., Ltd.

Tel: 0531-88682302 18615650139
Fax: 0531-62325738
Email: 3303447386@qq.com
Country: China
ProdList: 112
Advantage: 62

Porton Pharma Solutions Ltd.

Tel: 23-86083200-6540
Fax: 023860832006830
Email: jia.chen@portonpharma.com
Country: China
ProdList: 56
Advantage: 58

Beijing Huikang Boyuan Chemical Tech Co., Ltd

Tel: 010-68862197 13810598707
Fax: 010-68882204
Email: sales@huikangchem.com
Country: China
ProdList: 103
Advantage: 61

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44689
Advantage: 61

Jia Xing Isenchem Co.,Ltd

Tel: 0573-85285100 18627885956
Fax: 0573-85285100
Email: isenchem@163.com
Country: China
ProdList: 9413
Advantage: 66

Suzhou Zehou Biotechnology Co. , Ltd.

Tel: 0512-68716880 18075373931
Fax: 18075373931
Email: sales@growingchem.com
Country: China
ProdList: 191
Advantage: 64

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: chenyj@titansci.com
Country: China
ProdList: 14103
Advantage: 59

Anhui Lianchuang Biological Medicine Co.,Ltd

Tel: 0551-68779238 18056025720
Email: sales3@lcywhx.com
Country: China
ProdList: 158
Advantage: 57

Beijing Lunarsun Pharmaceutical Co.,LTD.

Tel: 86-10-64911848-8020.8010
Fax: 86-10-64946614
Email: sales@lunarsun.com.cn
Country: China
ProdList: 95
Advantage: 60

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42958
Advantage: 64

China Langchem Inc.

Tel: 021-58956006 15800617331
Fax: 021-58956100
Email: sales4@langchem.com
Country: China
ProdList: 204
Advantage: 57

Wuhan Fortuna Chemical Co., Ltd

Tel: 027-59207852 13308628970
Fax: QQ3130921841
Email: buy@fortunachem.com
Country: China
ProdList: 2872
Advantage: 58

Jinan Bond Chemical Technology Co., Ltd.

Tel: 86-531-88280989
Fax: 86-531-88280989
Email: mymail1996@126.com
Country: China
ProdList: 256
Advantage: 55

BioBioPha Co., Ltd.

Tel: 0871-65217109 13211707573;
Fax: 0871-65215563
Email: y.liu@mail.biobiopha.com
Country: China
ProdList: 5653
Advantage: 65

T&W GROUP

Tel: 021-61551611 13296011611
Fax: ＋86 21-50676805
Email: contact@trustwe.com
Country: China
ProdList: 9895
Advantage: 58

Chengdu Yuyang High-Tech Developing Co., Ltd

Tel: +86-28-61777709
Fax: +86-28-61777709
Email: yygk@yygk.com
Country: China
ProdList: 69
Advantage: 58

S.Z. PhyStandard Bio-Tech. Co., Ltd.

Tel: 0755-4000505016 13380397412
Fax: 0755 28094224
Email: 3001272453@qq.com
Country: China
ProdList: 5047
Advantage: 50

Tianjin Branch Chong pharmaceutical intermediates Co., Ltd.

Tel: 022-60116533 13207668525
Fax: 022-60979672
Email: saleskc@scipharmacn.com
Country: China
ProdList: 684
Advantage: 58

Shanghai Topbiochem Technology Co., Ltd

Tel: 021-58170097
Email: info@topbiochem.com
Country: China
ProdList: 9459
Advantage: 58

Shanghai Topbiochem Technology Co., Ltd

Tel: +86-21-60341587
Fax: +86-21-61294319
Email: sales@topbiochem.com
Country: China
ProdList: 6175
Advantage: 58

Shanghai T&W Pharmaceutical Co., Ltd.

Tel: +86 21 61551611
Fax: +86 21 50676805
Country: China
ProdList: 9891
Advantage: 58

Emei shan Hongsheng Pharmaceutical Co., LTD

Tel: 0833-6186278
Fax: 0833-5590359
Email: sales@hongshengpharm.com
Country: China
ProdList: 109
Advantage: 60

Syncozymes (Shanghai) Co.,Ltd.

Tel: 021-68187180-819 13681683526
Fax: 021-68187179
Email: lchen@syncozymes.com
Country: China
ProdList: 225
Advantage: 55

China Nobel Chem Co., Limited

Tel: +86(0)21 60484900
Fax: +86(0)21 60484900
Country: China
ProdList: 764
Advantage: 50

Tianjin Chempharmatech Co.,Ltd.

Tel: 022-66211079 13212288319
Fax: qq1405432731
Email: sales@chempharmatech.com
Country: China
ProdList: 868
Advantage: 55

Shanghai Twisun Bio-pharm Co.,Ltd

Tel: +86-21-33282107
Fax: +86-21-37285115
Country: China
ProdList: 107
Advantage: 60

Taizhou Tongxin Bio-Tech Co., Ltd

Tel: 0523-18601685-898 18652728585
Email: sales@allyrise.com
Country: China
ProdList: 2769
Advantage: 60

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 41462
Advantage: 60

Chongqing Carechem Co.,Ltd.

Tel: 18680818008/15802381793
Fax: 086-23-86109835
Email: cqudgh@126.com
Country: China
ProdList: 57
Advantage: 58

ChemStrong Scientific Co.,Ltd

Tel: 0755-0755-66853366 13670046396
Fax: 0755-28363542
Email: sales@chem-strong.com
Country: China
ProdList: 18042
Advantage: 56

Shanghai Pansopharm Technology Co., Ltd.

Tel: 021-20962833 15316628753
Fax: 021-2096-2832
Email: sales@pansopharm.com
Country: China
ProdList: 533
Advantage: 60

Chemfun Medical Technology(Shanghai) Co., Ltd.

Tel: 021-67220633 021-54824098
Fax: +86-21-54824069
Email: chemfun@chemfun.net
Country: China
ProdList: 491
Advantage: 58

Hunan HuaTeng Pharmaceutical Co., Ltd.,

Tel: 400-8592883 15367835770
Fax: 0731-82251112
Email: viola@huatengsci.com
Country: China
ProdList: 5875
Advantage: 58

Shanghai YuLue Chemical Co., Ltd.

Tel: 021-60345187 13671753212
Fax: 021-34702061
Email: lzz841106@aliyun.com
Country: China
ProdList: 10276
Advantage: 55

Hydragon Pharma Ltd

Tel: 021-50215258
Fax: 021-50215756
Email: market@hypharma.com
Country: China
ProdList: 321
Advantage: 58

Shandong Boluoda Biological Technology Co., Ltd.

Tel: 0531-58190570 15863796298
Email: 2310993908@qq.com
Country: China
ProdList: 1296
Advantage: 58

Tianjin Anhao Biological Technology Co., Ltd.

Tel
Email: sales@ahpharmatech.com
Country: China
ProdList: 5734
Advantage: 55

Credit Asia Chemical Co., Ltd.

Tel: +86 (21) 61124340
Fax: +86 (21) 6129-4103
Country: China
ProdList: 9756
Advantage: 58

Chizhou Kailong Import and Export Trade Co., Ltd.

Tel
Fax: -
Email: xg01_gj@163.com
Country: China
ProdList: 9484
Advantage: 50

Guangzhou Ciming Biological Technology Co., Ltd.

Tel: 020-38082199,29065168,38082986,29878298,29866629,4000192398
Fax: +86 (20)38082986
Country: China
ProdList: 830
Advantage: 60

AN PharmaTech Co Ltd

Tel: 86(21)68097365
Fax: 86(21)33321566
Email: sales@anpharma.net
Country: China
ProdList: 4891
Advantage: 55

Hangzhou Cheminspire Technology Co., Ltd.

Tel: 0571-89081561; 10006559855
Fax: 0571 89081561
Email: info@cheminspire.com
Country: China
ProdList: 412
Advantage: 58

ZHEJIANG ZETIAN FINE CHEMICALS CO.,LTD

Tel: 0571-87322520 18957127338
Fax: QQ:3007632051
Email: sales@zetchem.com
Country: China
ProdList: 482
Advantage: 55

Intelligence Pharm Science(Shanghai) Co., Ltd.

Tel: 021-57898186
Fax: 021-37699262
Country: China
ProdList: 449
Advantage: 55

Less

View Lastest Price from (S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran manufacturers

Sinoway Industrial co., ltd.

Product: Empagliflozin Intermediate 915095-94-2
Price: US $0.00/Kg/Bag
Min. Order: 2Kg/Bag
Purity: 99% up, High Density
Supply Ability: 20 tons
Release date: 2024-07-08

HangZhou RunYan Pharma Technology Co.,LTD.

Product: Empagliflozin Intermediate 915095-94-2
Price: US $0.00-0.00/g
Min. Order: 10000g
Purity: 99.0%min. HPLC
Supply Ability: 1000kg
Release date: 2024-09-12

Nanjing Fred Technology Co., Ltd

Product: (3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan 915095-94-2
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1 ton
Release date: 2024-01-03

915095-94-2, (S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuranRelated Search:

(S)-(5-broMo-2-chlorophenyl)(4-(tetrahydrofuran-3-yloxy)phenyl)Methanone (3S,4R)-4-(4-Fluorophenyl)-3-hydroxymethyl-1-methylpiperidine Thiazole Copper(II) chloride dihydrate Tetrahydrofuran Dimethyl fumarate 1-Propanol Brexpiprazole Intermediate 1 (R)-3-(p-toluenesulfonyl) oxytetrahydrofuran Empagliflozin (S)-(+)-3-Hydroxytetrahydrofuran 4-(5-broMo-2-chlorobenzyl)phenol (3S)-3-[4-[(5-Bromo-2-chlorophenyl)methyl]phenoxy]tetrahydrofuran Benzo[b]thiophene, 2-[(5-broMo-2-fluorophenyl)Methyl]- (2-Chloro-5-iodophenyl)[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methanone (2S,3R,4S,5S,6R)-2-(3-(4-((S)-tetrahydrofuran-3-yloxy)benzyl)-4-chlorophenyl)-tetrahydro-6-(hydroxyMethyl)-2-Methoxy-2H-pyran-3,4,5-triol 2,3,4,6-Tetra-O-benzyl-a-D-glucopyranosylbromide (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone

(3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan

(S)-3-(4-(2-chloro-5-iodobenzyl)phenoxy)-tetrahydrofuran

(S)-3-(4-(2-chloro-5-fluorobenzyl)phenoxy)-tetrahydrofuran

EMpagliflozin iMpurity C

(S)-4-iodo-1-chloro-2-(4-tetrahydrofuran-3-yloxy-benzyl)-benzene

(3S)-3-{4-[(2-chloro-5-iodophenyl)methyl]phenoxy}oxolane

(3S)-3-[4-(2-chloro-5-iodobenzyl)-phenoxy]-tetrahydrofuran

Furan, 3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-, (3S)-

Empagliflozin Intermediate1

3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan

(3S-3-(4)Chloro-5-Iodophenyl)Methyl)Phenoxy)Tetrahydro-Furan

1-chloro-2-(4-(cyclopentyloxy)benzyl)-4-iodobenzene

Englitin Impurity 28

(3S)-3-{4-[(2-chL

]phenoxy}oxoL

oro-5-iodophenyL

(3S)-3-[4-[(2-CHLORO-5-IODOPHENYL)METHYL]PHENOXY]TETRAHYDRO-FURAN 915095-94-2

(3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan(For export only)

(3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan ISO 9001：2015 REACH

Empagliflozin Impurity 110

(3S)-3-[4-[(5-Iodo-2- Chlorophenyl) Methyl] Phenoxy] Tetrahydrofuran

(3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-...

Empagliflozin Intermediate/ (3S)-3-[4-[(2-Chloro-5-Iodophenyl)Methyl]Phenoxy]Tetrahydro-Furan

(3S)-3-[4-4(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan

(3S)-3-[4-[(2-Chloro-5-iodophenyl) methyl] phenc

915095-94-2

C17H16ClIO2

Empagliflozin

Empagliflozin Intermediate

915095-94-2