ChemicalBook > CAS DataBase List > (S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran
(S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran
Physical Form Uses- Product Name
- (S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran
- CAS No.
- 915095-94-2
- Chemical Name
- (S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran
- Synonyms
- EMpagliflozin iMpurity C;(S)-4-iodo-1-chloro-2-(4-tetrahydrofuran-3-yloxy-benzyl)-benzene;]phenoxy}oxoL;oro-5-iodophenyL;(3S)-3-{4-[(2-chL;Englitin Impurity 28;Empagliflozin Impurity 110;Empagliflozin Intermediate1;(3S)-3-[4-[(2-Chloro-5-iodophenyl) methyl] phenc;1-chloro-2-(4-(cyclopentyloxy)benzyl)-4-iodobenzene
- CBNumber
- CB12657939
- Molecular Formula
- C17H16ClIO2
- Formula Weight
- 414.67
- MOL File
- 915095-94-2.mol
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(S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran Property
- Boiling point:
- 476.0±45.0 °C(Predicted)
- Density
- 1.578±0.06 g/cm3 (20 ºC 760 Torr)
- storage temp.
- 2-8°C(protect from light)
- solubility
- DMSO, Methanol (Slightly, Sonicated)
- form
- Solid
- color
- White to Off-White
- InChI
- InChI=1S/C17H16ClIO2/c18-17-6-3-14(19)10-13(17)9-12-1-4-15(5-2-12)21-16-7-8-20-11-16/h1-6,10,16H,7-9,11H2/t16-/m0/s1
- InChIKey
- YLUHNGIWRCCQMQ-INIZCTEOSA-N
- SMILES
- O1CC[C@H](OC2=CC=C(CC3=CC(I)=CC=C3Cl)C=C2)C1
- CAS DataBase Reference
- 915095-94-2
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
AK Scientific
- Product number
- 9598AF
- Product name
- (3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan
- Packaging
- 1g
- Price
- $39
- Updated
- 2021/12/16
AK Scientific
- Product number
- J95043
- Product name
- (3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan
- Packaging
- 5g
- Price
- $88
- Updated
- 2021/12/16
SynQuest Laboratories
- Product number
- 2H10-M-S0
- Product name
- (3S)-3-{4-[(2-Chloro-5-iodophenyl)methyl]phenoxy}oxolane
- Purity
- 97.0%
- Packaging
- 250mg
- Price
- $115
- Updated
- 2021/12/16
AK Scientific
- Product number
- 9598AF
- Product name
- (3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan
- Packaging
- 5g
- Price
- $118
- Updated
- 2021/12/16
AK Scientific
- Product number
- 9598AF
- Product name
- (3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan
- Packaging
- 10g
- Price
- $189
- Updated
- 2021/12/16
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(S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran Chemical Properties,Usage,Production
Physical Form
Solid
Uses
(3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran(915095-94-2) can be used as reactant/reagent in preparation of C-?aryl D-?glurofuranoside compounds useful as reference compounds in the quality control of gliflozin type medicine.
Description
(S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran is a pharmaceutical intermediate compound that is used in the preparation of empagliflozin. Empagliflozin is an inhibitor of sodium-glucose co-transporter protein-2 (SGLT2), which is used in the treatment of type 2 diabetes.
Preparation
0.5 mol of raw material and 0.6 mol of aluminum chloride were added to 2 mol of methanol at a temperature of 20° C, and then 0.6 mol of triethylsilane was added to the mixed solution. The mixture was stirred at 25° C for 1 h.The conversion is determined by HPLC analysis. After the reaction is complete, it is extracted and distilled under reduced pressure.Finally, (3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan was obtained through purification.
(S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran Preparation Products And Raw materials
Raw materials
Preparation Products
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(S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran Suppliers
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View Lastest Price from (S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran manufacturers
Hebei Dangtong Import and export Co LTD
- Product
- (3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan 915095-94-2
- Price
- US $100.00-70.00/kilograms
- Min. Order
- 100kilograms
- Purity
- 99%
- Supply Ability
- 100tons
- Release date
- 2023-03-01
Jinan Finer Chemical Co., Ltd
- Product
- (3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan 915095-94-2
- Price
- US $0.00/Kg/Drum
- Min. Order
- 10g
- Purity
- 99%
- Supply Ability
- 50mt
- Release date
- 2021-06-23
Nanjing Fred Technology Co., Ltd
- Product
- (3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan 915095-94-2
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1 ton
- Release date
- 2024-01-03
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