Physical Form Uses
ChemicalBook > CAS DataBase List > (S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran

(S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran

Physical Form Uses
Product Name
(S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran
CAS No.
915095-94-2
Chemical Name
(S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran
Synonyms
EMpagliflozin iMpurity C;(S)-4-iodo-1-chloro-2-(4-tetrahydrofuran-3-yloxy-benzyl)-benzene;]phenoxy}oxoL;oro-5-iodophenyL;(3S)-3-{4-[(2-chL;Englitin Impurity 28;Empagliflozin Impurity 110;Empagliflozin Intermediate1;(3S)-3-[4-[(2-Chloro-5-iodophenyl) methyl] phenc;1-chloro-2-(4-(cyclopentyloxy)benzyl)-4-iodobenzene
CBNumber
CB12657939
Molecular Formula
C17H16ClIO2
Formula Weight
414.67
MOL File
915095-94-2.mol
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(S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran Property

Boiling point:
476.0±45.0 °C(Predicted)
Density 
1.578±0.06 g/cm3 (20 ºC 760 Torr)
storage temp. 
2-8°C(protect from light)
solubility 
DMSO, Methanol (Slightly, Sonicated)
form 
Solid
color 
White to Off-White
InChI
InChI=1S/C17H16ClIO2/c18-17-6-3-14(19)10-13(17)9-12-1-4-15(5-2-12)21-16-7-8-20-11-16/h1-6,10,16H,7-9,11H2/t16-/m0/s1
InChIKey
YLUHNGIWRCCQMQ-INIZCTEOSA-N
SMILES
O1CC[C@H](OC2=CC=C(CC3=CC(I)=CC=C3Cl)C=C2)C1
CAS DataBase Reference
915095-94-2
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific
Product number
9598AF
Product name
(3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan
Packaging
1g
Price
$39
Updated
2021/12/16
AK Scientific
Product number
J95043
Product name
(3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan
Packaging
5g
Price
$88
Updated
2021/12/16
SynQuest Laboratories
Product number
2H10-M-S0
Product name
(3S)-3-{4-[(2-Chloro-5-iodophenyl)methyl]phenoxy}oxolane
Purity
97.0%
Packaging
250mg
Price
$115
Updated
2021/12/16
AK Scientific
Product number
9598AF
Product name
(3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan
Packaging
5g
Price
$118
Updated
2021/12/16
AK Scientific
Product number
9598AF
Product name
(3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan
Packaging
10g
Price
$189
Updated
2021/12/16
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(S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran Chemical Properties,Usage,Production

Physical Form

Solid

Uses

(3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran(915095-94-2) can be used as reactant/reagent in preparation of C-?aryl D-?glurofuranoside compounds useful as reference compounds in the quality control of gliflozin type medicine.

Description

(S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran is a pharmaceutical intermediate compound that is used in the preparation of empagliflozin. Empagliflozin is an inhibitor of sodium-glucose co-transporter protein-2 (SGLT2), which is used in the treatment of type 2 diabetes.

Preparation

0.5 mol of (S)-(2-chloro-5-iodophenyl)(4-((tetrahydrofuran-3-yl)oxy)phenyl)methanone and 0.6 mol of aluminum chloride were added to 2 mol of methanol at a temperature of 20° C, and then 0.6 mol of triethylsilane was added to the mixed solution. The mixture was stirred at 25° C for 1 h.The conversion is determined by HPLC analysis. After the reaction is complete, it is extracted and distilled under reduced pressure.Finally, (3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan (also known as (S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran) was obtained through purification.

(S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran Suppliers

Canada 1 China 355 Germany 1 India 17 United Kingdom 1 United States 7 Global 382
VladaChem GmbH
Tel
+49-7246-3082843
Email
info@vladachem.de
Country
Germany
ProdList
1859
Advantage
58
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View Lastest Price from (S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran manufacturers

Jinan Finer Chemical Co., Ltd
Product
(3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan 915095-94-2
Price
US $0.00/Kg/Drum
Min. Order
10g
Purity
99%
Supply Ability
50mt
Release date
2021-06-23
HangZhou RunYan Pharma Technology Co.,LTD.
Product
Empagliflozin Intermediate 915095-94-2
Price
US $0.00-0.00/g
Min. Order
10000g
Purity
99.0%min. HPLC
Supply Ability
1000kg
Release date
2024-09-12
WUHAN FORTUNA CHEMICAL CO., LTD
Product
(3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan 915095-94-2
Price
US $0.00-0.00/Kg/Drum
Min. Order
1KG
Purity
99%min
Supply Ability
1000kg
Release date
2021-11-19

915095-94-2, (S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuranRelated Search:

(S)-(5-broMo-2-chlorophenyl)(4-(tetrahydrofuran-3-yloxy)phenyl)Methanone (3S,4R)-4-(4-Fluorophenyl)-3-hydroxymethyl-1-methylpiperidine Thiazole Copper(II) chloride dihydrate Tetrahydrofuran Dimethyl fumarate 1-Propanol Brexpiprazole Intermediate 1 (R)-3-(p-toluenesulfonyl) oxytetrahydrofuran Empagliflozin (S)-(+)-3-Hydroxytetrahydrofuran 4-(5-broMo-2-chlorobenzyl)phenol (3S)-3-[4-[(5-Bromo-2-chlorophenyl)methyl]phenoxy]tetrahydrofuran Benzo[b]thiophene, 2-[(5-broMo-2-fluorophenyl)Methyl]- (2-Chloro-5-iodophenyl)[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methanone (2S,3R,4S,5S,6R)-2-(3-(4-((S)-tetrahydrofuran-3-yloxy)benzyl)-4-chlorophenyl)-tetrahydro-6-(hydroxyMethyl)-2-Methoxy-2H-pyran-3,4,5-triol 2,3,4,6-Tetra-O-benzyl-a-D-glucopyranosylbromide (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone

  • (3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan
  • (S)-3-(4-(2-chloro-5-iodobenzyl)phenoxy)-tetrahydrofuran
  • (S)-3-(4-(2-chloro-5-fluorobenzyl)phenoxy)-tetrahydrofuran
  • EMpagliflozin iMpurity C
  • (S)-4-iodo-1-chloro-2-(4-tetrahydrofuran-3-yloxy-benzyl)-benzene
  • (3S)-3-{4-[(2-chloro-5-iodophenyl)methyl]phenoxy}oxolane
  • (3S)-3-[4-(2-chloro-5-iodobenzyl)-phenoxy]-tetrahydrofuran
  • Furan, 3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-, (3S)-
  • Empagliflozin Intermediate1
  • 3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan
  • (3S-3-(4)Chloro-5-Iodophenyl)Methyl)Phenoxy)Tetrahydro-Furan
  • 1-chloro-2-(4-(cyclopentyloxy)benzyl)-4-iodobenzene
  • Englitin Impurity 28
  • (3S)-3-{4-[(2-chL
  • ]phenoxy}oxoL
  • oro-5-iodophenyL
  • (3S)-3-[4-[(2-CHLORO-5-IODOPHENYL)METHYL]PHENOXY]TETRAHYDRO-FURAN 915095-94-2
  • (3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan(For export only)
  • (3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan ISO 9001：2015 REACH
  • Empagliflozin Impurity 110
  • (3S)-3-[4-[(5-Iodo-2- Chlorophenyl) Methyl] Phenoxy] Tetrahydrofuran
  • (3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-...
  • Empagliflozin Intermediate/ (3S)-3-[4-[(2-Chloro-5-Iodophenyl)Methyl]Phenoxy]Tetrahydro-Furan
  • (3S)-3-[4-4(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan
  • (3S)-3-[4-[(2-Chloro-5-iodophenyl) methyl] phenc
  • 915095-94-2
  • C17H16ClIO2
  • Empagliflozin
  • Empagliflozin Intermediate
  • 915095-94-2