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4-Amino-3-chlorophenol

Product Name
4-Amino-3-chlorophenol
CAS No.
17609-80-2
Chemical Name
4-Amino-3-chlorophenol
Synonyms
4-amino-3-chloro-pheno;3-chloro-4-aminophenol;lenvaint-G;Brn 2802558;synthesis-023;synthesis-1-013;Einecs 241-583-3;Levatinib Impurity 55;4-AMINO-3-CHLOROPHENOL;lenvatinib intermediate
CBNumber
CB1266045
Molecular Formula
C6H6ClNO
Formula Weight
143.57
MOL File
17609-80-2.mol
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4-Amino-3-chlorophenol Property

Melting point:
159-160℃
Boiling point:
287.3±25.0 °C(Predicted)
Density 
1.406±0.06 g/cm3(Predicted)
RTECS 
SJ5710000
storage temp. 
2-8°C(protect from light)
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Crystalline Powder
pka
9.26±0.18(Predicted)
color 
White
Stability:
Hygroscopic
InChI
InChI=1S/C6H6ClNO/c7-5-3-4(9)1-2-6(5)8/h1-3,9H,8H2
InChIKey
PNLPXABQLXSICH-UHFFFAOYSA-N
SMILES
C1(O)=CC=C(N)C(Cl)=C1
CAS DataBase Reference
17609-80-2(CAS DataBase Reference)
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Safety

HazardClass 
6.1
HS Code 
2922290090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Alfa Aesar
Product number
H66310
Product name
4-Amino-3-chlorophenol, 95%
Packaging
1g
Price
$293
Updated
2023/06/20
Alfa Aesar
Product number
H66310
Product name
4-Amino-3-chlorophenol, 95%
Packaging
250mg
Price
$88.9
Updated
2021/12/16
TRC
Product number
A601735
Product name
4-Amino-3-chlorophenol
Packaging
250mg
Price
$45
Updated
2021/12/16
TRC
Product number
A601735
Product name
4-Amino-3-chlorophenol
Packaging
1g
Price
$55
Updated
2021/12/16
SynQuest Laboratories
Product number
4656-5-1F
Product name
4-Amino-3-chlorophenol
Packaging
5G
Price
$114
Updated
2021/12/16
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4-Amino-3-chlorophenol Chemical Properties,Usage,Production

Chemical Properties

Light yellow solid

Uses

4-Amino-3-Chlorophenol acts as a synthetic reagent for the preparation of Benzothiazole-based ureas as potential ABAD/17β-HSD10 modulators for Alzheimer''s disease treatment.

Application

The 4-amino-3-chlorophenol is a crucial intermediate for preparing a tyrosine kinase inhibitor, tivozanib, and a late liver cancer drug, lenvatinib. As a crucial pharmaceutical chemical intermediate, 4-amino-3-chlorophenol is widely applied to the design and synthesis of medicaments for resisting tumors, cardiovascular diseases, neurological diseases, and the like.

Synthesis

Starting from o-chloronitrobenzene with introducing hydroxyl groups in the presence of strong acids and molybdenum salts as catalysts could synthesize 4-amino-3-chlorophenol. Besides, using m-chlorophenol as a starting material and introducing hydroxyl on a benzene ring through diazotization and coupling also could synthesize 4-Amino-3-chlorophenol.

4-Amino-3-chlorophenol Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Amino-3-chlorophenol Suppliers

China 314 Germany 1 India 6 United Kingdom 6 United States 16 Global 343
Novachemistry
Tel
44-20819178-90 02081917890
Fax
(0)2080432064
Email
info@novachemistry.com
Country
United Kingdom
ProdList
4381
Advantage
58
Carbosynth
Tel
--
Fax
--
Email
sales@carbosynth.com
Country
United Kingdom
ProdList
6005
Advantage
58
Leancare Ltd.
Tel
--
Fax
--
Email
enquiry@leancare.co.uk
Country
United Kingdom
ProdList
6446
Advantage
42
Apollo Scientific Ltd.
Tel
--
Fax
--
Email
sales@apolloscientific.co.uk
Country
United Kingdom
ProdList
6084
Advantage
88
Sinbond Industiral Co., Ltd.
Tel
--
Fax
--
Email
cici1124@gmail.com
Country
United Kingdom
ProdList
248
Advantage
50
Eurolabs Limited
Tel
--
Fax
--
Country
United Kingdom
ProdList
6309
Advantage
46
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View Lastest Price from 4-Amino-3-chlorophenol manufacturers

Jinan Million Pharmaceutical Co., Ltd
Product
4-Amino-3-chlorophenol 17609-80-2
Price
US $1.00-0.50/kg
Min. Order
1kg
Purity
99%
Supply Ability
200
Release date
2023-12-11
Hebei Zhuanglai Chemical Trading Co Ltd
Product
4-Amino-3-Chlorophenol 17609-80-2
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 ton
Release date
2024-12-16
WUHAN FORTUNA CHEMICAL CO., LTD
Product
4-Amino-3-chlorophenol 17609-80-2
Price
US $0.00-0.00/Kg/Drum
Min. Order
1KG
Purity
99%min
Supply Ability
500KGS
Release date
2021-07-09

17609-80-2, 4-Amino-3-chlorophenolRelated Search:

4-Amino-3-chlorophenol hydrochloride,98%,4-AMINO-3-CHLOROPHENOL HCL,4-AMINO-3-CHLOROPHENOL HYDROCHLORIDE Tris(hydroxymethyl)aminomethane 4-Aminophenol 2-Aminophenol 4-Chlorophenol 6-Aminocaproic acid 3-Chlorophenol Glycine 3-Aminophenol ALTRENOGEST CHLORTHION 1-AMINO-2-CHLORO-4-HYDROXY-9,10-ANTHRACENEDIONE 2,6-DICHLORO-4-(TRIFLUOROMETHOXY)ANILINE Lufenuron 4-METHOXY-2-CHLOROANILINE 2-Amino-6-chlorophenol-4-sulfonic acid 2-Methyl-5-amino-4-chlorophenol 5-AMINO-2-CHLOROPHENOL,3-amino-6-chloropheno

  • AMINO(4-)-3-CHLOROPHENOL
  • 4-AMINO-3-CHLOROPHENOL
  • 3-chloro-4-aminophenol
  • 4-amino-3-chloro-pheno
  • Brn 2802558
  • Einecs 241-583-3
  • Phenol, 4-amino-3-chloro-
  • lenvaint-G
  • lenvatinib intermediate
  • synthesis-023
  • synthesis-1-013
  • 4-Amino-3-chlorophenol 17609-80-2
  • Lenvatinib Intermediate V
  • Levatinib Impurity 55
  • 17609-80-2
  • 17609-80-2