4-Amino-3-chlorophenol
- Product Name
- 4-Amino-3-chlorophenol
- CAS No.
- 17609-80-2
- Chemical Name
- 4-Amino-3-chlorophenol
- Synonyms
- 4-amino-3-chloro-pheno;3-chloro-4-aminophenol;lenvaint-G;Brn 2802558;synthesis-023;synthesis-1-013;Einecs 241-583-3;Levatinib Impurity 55;4-AMINO-3-CHLOROPHENOL;lenvatinib intermediate
- CBNumber
- CB1266045
- Molecular Formula
- C6H6ClNO
- Formula Weight
- 143.57
- MOL File
- 17609-80-2.mol
4-Amino-3-chlorophenol Property
- Melting point:
- 159-160℃
- Boiling point:
- 287.3±25.0 °C(Predicted)
- Density
- 1.406±0.06 g/cm3(Predicted)
- RTECS
- SJ5710000
- storage temp.
- 2-8°C(protect from light)
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Crystalline Powder
- pka
- 9.26±0.18(Predicted)
- color
- White
- Stability:
- Hygroscopic
- InChI
- InChI=1S/C6H6ClNO/c7-5-3-4(9)1-2-6(5)8/h1-3,9H,8H2
- InChIKey
- PNLPXABQLXSICH-UHFFFAOYSA-N
- SMILES
- C1(O)=CC=C(N)C(Cl)=C1
- CAS DataBase Reference
- 17609-80-2(CAS DataBase Reference)
Safety
- HazardClass
- 6.1
- HS Code
- 2922290090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- H66310
- Product name
- 4-Amino-3-chlorophenol, 95%
- Packaging
- 1g
- Price
- $293
- Updated
- 2023/06/20
- Product number
- H66310
- Product name
- 4-Amino-3-chlorophenol, 95%
- Packaging
- 250mg
- Price
- $88.9
- Updated
- 2021/12/16
- Product number
- A601735
- Product name
- 4-Amino-3-chlorophenol
- Packaging
- 250mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- A601735
- Product name
- 4-Amino-3-chlorophenol
- Packaging
- 1g
- Price
- $55
- Updated
- 2021/12/16
- Product number
- 4656-5-1F
- Product name
- 4-Amino-3-chlorophenol
- Packaging
- 5G
- Price
- $114
- Updated
- 2021/12/16
4-Amino-3-chlorophenol Chemical Properties,Usage,Production
Chemical Properties
Light yellow solid
Uses
4-Amino-3-Chlorophenol acts as a synthetic reagent for the preparation of Benzothiazole-based ureas as potential ABAD/17β-HSD10 modulators for Alzheimer''s disease treatment.
Application
The 4-amino-3-chlorophenol is a crucial intermediate for preparing a tyrosine kinase inhibitor, tivozanib, and a late liver cancer drug, lenvatinib. As a crucial pharmaceutical chemical intermediate, 4-amino-3-chlorophenol is widely applied to the design and synthesis of medicaments for resisting tumors, cardiovascular diseases, neurological diseases, and the like.
Synthesis
Starting from o-chloronitrobenzene with introducing hydroxyl groups in the presence of strong acids and molybdenum salts as catalysts could synthesize 4-amino-3-chlorophenol. Besides, using m-chlorophenol as a starting material and introducing hydroxyl on a benzene ring through diazotization and coupling also could synthesize 4-Amino-3-chlorophenol.
4-Amino-3-chlorophenol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Amino-3-chlorophenol manufacturers
- Product
- 4-Amino-3-chlorophenol 17609-80-2
- Price
- US $1.00-0.50/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 200
- Release date
- 2023-12-11
- Product
- 4-Amino-3-Chlorophenol 17609-80-2
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20 ton
- Release date
- 2024-12-16
- Product
- 4-Amino-3-chlorophenol 17609-80-2
- Price
- US $0.00-0.00/Kg/Drum
- Min. Order
- 1KG
- Purity
- 99%min
- Supply Ability
- 500KGS
- Release date
- 2021-07-09