ChemicalBook > CAS DataBase List > GSK2838232

GSK2838232

Product Name
GSK2838232
CAS No.
1443461-21-9
Chemical Name
GSK2838232
Synonyms
CS-947;EX-A202;GSK2838232;HIV Inhibitor GS2838232;GSK2838232(GSK2838232A);HIV Inhibitor GSK2838232;GSK-2838232A; GSK 2838232A;(3beta)-3-(3-Carboxy-3-methyl-1-oxobutoxy)-17-[(1R)-2-[[(3-chlorophenyl)methyl][2-(dimethylamino)ethyl]amino]-1-hydroxyethyl]-28-norlup-18-en-21-one;28-Norlup-18-en-21-one, 3-(3-carboxy-3-methyl-1-oxobutoxy)-17-[(1R)-2-[[(3-chlorophenyl)methyl][2-(dimethylamino)ethyl]amino]-1-hydroxyethyl]-, (3β)-
CBNumber
CB12664173
Molecular Formula
C48H73ClN2O6
Formula Weight
809.56
MOL File
1443461-21-9.mol
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GSK2838232 Property

Boiling point:
817.1±65.0 °C(Predicted)
Density 
1.17±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
Powder
pka
4.48±0.28(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ApexBio Technology
Product number
B5818
Product name
GSK2838232
Packaging
5mg
Price
$551
Updated
2021/12/16
ApexBio Technology
Product number
B5818
Product name
GSK2838232
Packaging
10mg
Price
$788
Updated
2021/12/16
ApexBio Technology
Product number
B5818
Product name
GSK2838232
Packaging
50mg
Price
$2363
Updated
2021/12/16
ApexBio Technology
Product number
B5818
Product name
GSK2838232
Packaging
100mg
Price
$3308
Updated
2021/12/16
DC Chemicals
Product number
DC7847
Product name
HIVInhibitorGSK2838232
Purity
>98%
Packaging
1g
Price
$2500
Updated
2021/12/16
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GSK2838232 Chemical Properties,Usage,Production

Biological Activity

gsk2838232 is an hiv-1 maturation inhibitor [1] [2].hiv-1 maturation inhibitors disrupt the cleavage of the hiv-1 gag protein immediate precursor by the enzyme hiv-1 protease. maturation inhibitors bind the gag protein, which leads to the formation of immature, noninfectious virus particles incapable of infecting other cells. also, maturation inhibitors inhibit hiv infections with resistance.gsk2838232 is a hiv-1 maturation inhibitor and is active against a broad range of isolates, including those resistant to bevirimat [1]. gsk2838232 was developed for the treatment of chronic hiv infection. a phase i study in hiv-negative individuals had been completed. single doses of 5, 10 or 20 mg gsk2838232 were used to evaluate the initial safety, tolerability, pharmacokinetics profile, and the effects of food and ritonavir on gsk2838232’s bioavailability and pharmacokinetics [2].

References

[1]. olender sa, taylor bs, wong m, et al. croi 2015: advances in antiretroviral therapy. croi 2015 highlights: antiretroviral therapy volume 23 issue 1 march/april 2015.
[2]. horn t, collins s. the antiretroviral pipeline. antiretrovirals, 2014 pipeline report.

GSK2838232 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from GSK2838232 manufacturers

Career Henan Chemical Co
Product
(3beta)-3-(3-Carboxy-3-methyl-1-oxobutoxy)-17-[(1R)-2-[[(3-chlorophenyl)methyl][2-(dimethylamino)ethyl]amino]-1-hydroxyethyl]-28-norlup-18-en-21-one 1443461-21-9
Price
US $1.00/KG
Min. Order
1KG
Purity
Min98% HPLC
Supply Ability
g/kg/ton
Release date
2019-12-23
Career Henan Chemical Co
Product
(3beta)-3-(3-Carboxy-3-methyl-1-oxobutoxy)-17-[(1R)-2-[[(3-chlorophenyl)methyl][2-(dimethylamino)ethyl]amino]-1-hydroxyethyl]-28-norlup-18-en-21-one 1443461-21-9
Price
US $1.00/KG
Min. Order
1KG
Purity
Min98% HPLC
Supply Ability
g/kg/ton
Release date
2019-12-20

1443461-21-9, GSK2838232Related Search:

GSK2814338 GSK-2256098 GSK-25 S)-1-(sec-butyl)-N-((4,6-diMethyl-2-oxo-1,2-dihydropyridin-3-yl)Methyl)-3-Methyl-6-(6-(piperazin-1-yl)pyridin-3-yl)-1H-indole-4-carboxaMide 7Methyl-5-(1-{[3-(trifluoroMethyl)phenyl]acetyl}-2,3-dihydro1Hindol-5-yl)7Hpyrrolo[2,3d]pyriMidin-4-aMine GSK 2801 GSK2636771 GSK2879552 GSK2795039 GSK 2330672

  • GSK2838232
  • (3beta)-3-(3-Carboxy-3-methyl-1-oxobutoxy)-17-[(1R)-2-[[(3-chlorophenyl)methyl][2-(dimethylamino)ethyl]amino]-1-hydroxyethyl]-28-norlup-18-en-21-one
  • GSK-2838232A; GSK 2838232A
  • CS-947
  • GSK2838232(GSK2838232A)
  • HIV Inhibitor GS2838232
  • 28-Norlup-18-en-21-one, 3-(3-carboxy-3-methyl-1-oxobutoxy)-17-[(1R)-2-[[(3-chlorophenyl)methyl][2-(dimethylamino)ethyl]amino]-1-hydroxyethyl]-, (3β)-
  • EX-A202
  • HIV Inhibitor GSK2838232
  • 1443461-21-9
  • C48H73ClN2O6