ChemicalBook > CAS DataBase List > P-5091

P-5091

Product Name: P-5091
CAS No.: 882257-11-6
Chemical Name: P-5091
Synonyms: P5091;CS-726;P 5091;P-5091;P005091;P 005091;P-005091;P5091, >=98%;P005091(P5091);P5091 (P005091)
CBNumber: CB12668070
Molecular Formula: C12H7Cl2NO3S2
Formula Weight: 348.22
MOL File: 882257-11-6.mol

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P-5091 Property

Boiling point:: 452.4±45.0 °C(Predicted)
Density: 1.60±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: soluble10mg/mL, clear
form: powder
color: light yellow to dark yellow
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.

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Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 45
RIDADR: UN 2811 6.1 / PGIII
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P273Avoid release to the environment.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0770
Product name: P5091
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $96.6
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML0770
Product name: P5091
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $380
Updated: 2025/07/31

Cayman Chemical

Product number: 15224
Product name: P005091
Purity: ≥98%
Packaging: 5mg
Price: $66
Updated: 2024/03/01

Cayman Chemical

Product number: 15224
Product name: P005091
Purity: ≥98%
Packaging: 10mg
Price: $106
Updated: 2024/03/01

Cayman Chemical

Product number: 15224
Product name: P005091
Purity: ≥98%
Packaging: 25mg
Price: $228
Updated: 2024/03/01

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P-5091 Chemical Properties,Usage,Production

Description

P5091 (882257-11-6) is a selective inhibitor of the ubiquitin-specific protease USP7 ( IC50=4.2 μM).1,2 Induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance.1?P5091 displays antiangiogenic activity in vivo.2?Cell permeable

Uses

P005091 is a selective dual inhibitor of the cancer-related deubiquitylating proteases USP7 and USP47.

Uses

P5091 has been used:

as a ubiquitin specific peptidase 47 (USP47) inhibitor in 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay to evaluate the cellular viability of MCF-10A cells
as a USP7 inhibitor to study the regulatory role for USP7 on inflammasome activation
as USP7 inhibitor in drug susceptibility assays to study its effect on bone marrow?resident tumor cells (BMRTCs)/ circulating tumor cells (CTCs)

Biochem/physiol Actions

P5091 plays an important role in ovarian cancer, as it can prevent the growth of cells and can promote necrosis and apoptosis.

in vivo

In animal tumor model studies, P005091 is well tolerated, inhibits tumor growth, and prolongs survival. Combining P005091 with lenalidomide, HDAC inhibitor SAHA, or dexamethasone triggers synergistic anti-MM activity^[1].

References

[1] DHARMINDER CHAUHAN. A small molecule inhibitor of ubiquitin-specific protease-7 induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance.[J]. Cancer Cell, 2012, 22 3: 345-358. DOI:10.1016/j.ccr.2012.08.007
[2] JOSEPH WEINSTOCK. Selective Dual Inhibitors of the Cancer-Related Deubiquitylating Proteases USP7 and USP47[J]. ACS Medicinal Chemistry Letters, 2012, 3 10: 789-792. DOI:10.1021/ml200276j

P-5091 Preparation Products And Raw materials

Raw materials

Preparation Products

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P-5091 Suppliers

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View Lastest Price from P-5091 manufacturers

Career Henan Chemica Co

Product: P-5091 882257-11-6
Price: US $0.01/KG
Min. Order: 1KG
Purity: 95%-99%
Supply Ability: 1kg; 5kg; 10kg
Release date: 2020-10-27

882257-11-6, P-5091Related Search:

AAL-993 NVP-BEZ 235 Apigenin INDIRUBIN-3'-MONOXIME Bortezomib PR-619 Degrasyn (WP1130) 1-[1-(4-Fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-(1-pyrrolidinyl)ethanone MG-132 P 22077

1-[5-(2,3-dichlorophenyl)sulfanyl-4-nitro-2-thienyl]ethanone

P5091, >=98%

CS-726

P5091; P-005091; P 005091; P 5091; P-5091

1-[5-(2,3-Dichloro-phenylsulfanyl)-4-nitro-thiophen-2-yl]-ethanone

Ethanone, 1-[5-[(2,3-dichlorophenyl)thio]-4-nitro-2-thienyl]-

1-[5-[(2,3-Dichlorophenyl)thio]-4-nitro-2-thienyl]-ethanone P005091

P005091(P5091)

P 005091

P 5091

P005091

P-005091

P5091

P-5091

1-(5-(2,3-dichlorophenylthio)-4-nitrothiophen-2-yl)ethanone

P5091 (P005091)

1-[5-[(2,3-Dichlorophenyl)thio]-4-n-itro-2-thienyl]ethanone

P-5091 USP/EP/BP

1-(5-((2,3-Dichlorophenyl)thio)-4-nitrothiophen-2-yl)ethan-1-one

P5091, USP-7 inhibitor

P005091, 10 mM in DMSO

P5091 (P005091) ，S7132

882257-11-6

C12H7Cl2NO3S2

Inhibitors