P-5091
- Product Name
- P-5091
- CAS No.
- 882257-11-6
- Chemical Name
- P-5091
- Synonyms
- P5091;CS-726;P 5091;P-5091;P005091;P 005091;P-005091;P5091, >=98%;P005091(P5091);P5091 (P005091)
- CBNumber
- CB12668070
- Molecular Formula
- C12H7Cl2NO3S2
- Formula Weight
- 348.22
- MOL File
- 882257-11-6.mol
P-5091 Property
- Boiling point:
- 452.4±45.0 °C(Predicted)
- Density
- 1.60±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: soluble10mg/mL, clear
- form
- powder
- color
- light yellow to dark yellow
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
N-Bromosuccinimide Price
- Product number
- SML0770
- Product name
- P5091
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $134
- Updated
- 2024/03/01
- Product number
- SML0770
- Product name
- P5091
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $435
- Updated
- 2024/03/01
- Product number
- 15224
- Product name
- P005091
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $66
- Updated
- 2024/03/01
- Product number
- 15224
- Product name
- P005091
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $106
- Updated
- 2024/03/01
- Product number
- 15224
- Product name
- P005091
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $228
- Updated
- 2024/03/01
P-5091 Chemical Properties,Usage,Production
Description
P5091 (882257-11-6) is a selective inhibitor of the ubiquitin-specific protease USP7 ( IC50=4.2 μM).1,2 Induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance.1?P5091 displays antiangiogenic activity in vivo.2?Cell permeable
Uses
P005091 is a selective dual inhibitor of the cancer-related deubiquitylating proteases USP7 and USP47.
Uses
P5091 has been used:
- as a ubiquitin specific peptidase 47 (USP47) inhibitor in 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay to evaluate the cellular viability of MCF-10A cells
- as a USP7 inhibitor to study the regulatory role for USP7 on inflammasome activation
- as USP7 inhibitor in drug susceptibility assays to study its effect on bone marrow?resident tumor cells (BMRTCs)/ circulating tumor cells (CTCs)
Biochem/physiol Actions
P5091 plays an important role in ovarian cancer, as it can prevent the growth of cells and can promote necrosis and apoptosis.
References
1) Chauhan et al. (2012), A small molecule inhibitor of ubiquitin-specific protease-7 induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance; Cancer Cell, 22 345 2) Weinstock et al. (2012), Selective dual inhibitors of the cancer-related deubiquitylating proteases USP7 and USP47; ACS Med. Chem. Lett., 3 789
P-5091 Preparation Products And Raw materials
Raw materials
Preparation Products
P-5091 Suppliers
View Lastest Price from P-5091 manufacturers
- Product
- P-5091 882257-11-6
- Price
- US $0.01/KG
- Min. Order
- 1KG
- Purity
- 95%-99%
- Supply Ability
- 1kg; 5kg; 10kg
- Release date
- 2020-10-27