ChemicalBook > CAS DataBase List > CNX-1351

CNX-1351

Product Name
CNX-1351
CAS No.
1276105-89-5
Chemical Name
CNX-1351
Synonyms
CS-1069;CNX-1351;CNX1351cas;CNX-1351, >=98%;CNX-1351; CNX 1351; CNX1351;CNX1351,inhibit,PI3K,Phosphoinositide 3-kinase,Inhibitor,CNX 1351,CNX-1351;1-(4-((2-(1H-indazol-4-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-6-methylhept-5-ene-1,4-dione;1-[4-[[2-(1H-Indazol-4-yl)-4-(4-morpholinyl)thieno[3,2-d]pyrimidin-6-yl]methyl]-1-piperazinyl]-6-methyl-5-heptene-1,4-dione;5-Heptene-1,4-dione, 1-[4-[[2-(1H-indazol-4-yl)-4-(4-morpholinyl)thieno[3,2-d]pyrimidin-6-yl]methyl]-1-piperazinyl]-6-methyl-;1-[4-[[2-(1H-Indazol-4-yl)-4-(4-morpholinyl)thieno[3,2-d]pyrimidin-6-yl]methyl]-1-piperazinyl]-6-methyl-5-heptene-1,4-dione CNX1351
CBNumber
CB12668207
Molecular Formula
C30H35N7O3S
Formula Weight
573.71
MOL File
1276105-89-5.mol
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CNX-1351 Property

Density 
1.328±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO : 33.33 mg/mL (58.10 mM; Need ultrasonic)
form 
Powder
pka
12.22±0.40(Predicted)
color 
White to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
30264
Product name
CNX-1351
Packaging
5mg
Price
$116
Updated
2024/03/01
Cayman Chemical
Product number
30264
Product name
CNX-1351
Packaging
25mg
Price
$442
Updated
2024/03/01
Cayman Chemical
Product number
30264
Product name
CNX-1351
Packaging
1mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
30264
Product name
CNX-1351
Packaging
10mg
Price
$213
Updated
2024/03/01
ChemScene
Product number
CS-3610
Product name
CNX-1351
Purity
99.88%
Packaging
10mg
Price
$240
Updated
2021/12/16
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CNX-1351 Chemical Properties,Usage,Production

Biological Activity

CNX-1351 is a potent and selective PI3Kα inhibitor with IC50 of 6.8 nM.

in vivo

CNX-1351 inhibits p-Akt Ser473 in mouse spleens and bonds to PI3Kα in vivo. It is delivered into the intraperitoneal cavity of nude mice at 100 mg/kg once a day for 5 consecutive days (n=3 mice per group).

target

PI3Kα

6.8 nM (IC 50 )

PI3Kβ

166 nM (IC 50 )

PI3Kδ

240.3 nM (IC 50 )

PI3Kγ

3020 nM ( IC 50 )

CNX-1351 Preparation Products And Raw materials

Raw materials

Preparation Products

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CNX-1351 Suppliers

China 53 United States 9 Global 62
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
Country
United States
ProdList
2782
Advantage
58
Target molecule Corp.
Tel
857-239-0968
Fax
857-239-8801
Email
service1@targetmol.com
Country
United States
ProdList
2559
Advantage
60
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4660
Advantage
60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32161
Advantage
58
Cckinase, Inc.
Tel
+1 (732)236-3202
Email
sales@cckinase.com
Country
United States
ProdList
2738
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
52924
Advantage
58
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
MedChemExpress
Tel
--
Fax
--
Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58

1276105-89-5, CNX-1351Related Search:

Y16 TENOVIN-1 LY 303511 (hydrochloride) PFK-015 CCT 137690 CTS-1027 TG101209 BIX 02189 BMS 833923 MS436 Mutant IDH1 inhibitor

  • 1-[4-[[2-(1H-Indazol-4-yl)-4-(4-morpholinyl)thieno[3,2-d]pyrimidin-6-yl]methyl]-1-piperazinyl]-6-methyl-5-heptene-1,4-dione CNX1351
  • CNX-1351, >=98%
  • CNX-1351
  • 1-[4-[[2-(1H-Indazol-4-yl)-4-(4-morpholinyl)thieno[3,2-d]pyrimidin-6-yl]methyl]-1-piperazinyl]-6-methyl-5-heptene-1,4-dione
  • 1-(4-((2-(1H-indazol-4-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-6-methylhept-5-ene-1,4-dione
  • CS-1069
  • CNX-1351; CNX 1351; CNX1351
  • CNX1351cas
  • CNX1351,inhibit,PI3K,Phosphoinositide 3-kinase,Inhibitor,CNX 1351,CNX-1351
  • 5-Heptene-1,4-dione, 1-[4-[[2-(1H-indazol-4-yl)-4-(4-morpholinyl)thieno[3,2-d]pyrimidin-6-yl]methyl]-1-piperazinyl]-6-methyl-
  • 1276105-89-5
  • C30H35N7O3S
  • Inhibitors