ChemicalBook > CAS DataBase List > 3-Cyano-2-fluoropyridine

3-Cyano-2-fluoropyridine

Product Name
3-Cyano-2-fluoropyridine
CAS No.
3939-13-7
Chemical Name
3-Cyano-2-fluoropyridine
Synonyms
3-Cyano-2-fluoropyri;2-Fluoronicotinonitrile;2-Fluoro-3-cyanopridine;3-CYANO-2-FLUOROPYRIDINE;4-Fluoro-nicotinonitrile;3-Fluoro-4-cyanopyridine;3-Cyano-4-fluoropyridine;2-FLUORO-3-CYANOPYRIDINE;3-Cyano-2-fluoropyridine,98%;3-Cyano-2-fluoropyridine >
CBNumber
CB1267077
Molecular Formula
C6H3FN2
Formula Weight
122.1
MOL File
3939-13-7.mol
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3-Cyano-2-fluoropyridine Property

Melting point:
27-30°C
Boiling point:
214.6±20.0 °C(Predicted)
Density 
1.24±0.1 g/cm3(Predicted)
Flash point:
98℃
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
form 
powder to lump
pka
-3.88±0.10(Predicted)
color 
White to Dark green
BRN 
386567
InChI
InChI=1S/C6H3FN2/c7-6-5(4-8)2-1-3-9-6/h1-3H
InChIKey
USIDQCCXMGJOJM-UHFFFAOYSA-N
SMILES
C1(F)=NC=CC=C1C#N
CAS DataBase Reference
3939-13-7(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
20/21/22-36/37/38-5-36/38-22
Safety Statements 
26-36/37/39-36-24/25-23-3
RIDADR 
3276
WGK Germany 
3
Hazard Note 
Harmful/Irritant
HazardClass 
6.1
PackingGroup 
III
HS Code 
29333990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
736058
Product name
2-Fluoropyridine-3-carbonitrile
Purity
97%
Packaging
1g
Price
$24
Updated
2023/06/20
Sigma-Aldrich
Product number
736058
Product name
2-Fluoropyridine-3-carbonitrile
Purity
97%
Packaging
5g
Price
$84.3
Updated
2023/06/20
TCI Chemical
Product number
C2538
Product name
3-Cyano-2-fluoropyridine
Purity
>98.0%(GC)
Packaging
5g
Price
$50
Updated
2025/07/31
TCI Chemical
Product number
C2538
Product name
3-Cyano-2-fluoropyridine
Purity
>98.0%(GC)
Packaging
25g
Price
$187
Updated
2025/07/31
TRC
Product number
F593693
Product name
2-Fluoronicotinonitrile
Packaging
500mg
Price
$65
Updated
2021/12/16
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3-Cyano-2-fluoropyridine Chemical Properties,Usage,Production

Uses

3-Cyano-2-fluoropyridine have been successfully used in preparation of compounds with diverse spectrum of biological activity.  Other 3-cyano-2-fluoropyridine can potentially be used as promising agents for the positron emission tomography (PET). Additionally, it has previously been demonstrated that 3-cyanopyridines can be transformed into -amides, -carboxylic acids, and -esters. 

Synthesis

6602-54-6

3939-13-7

General method: 2-chloro-3-cyanopyridine (1.00 g, 6.76 mmol) was dissolved in DMSO (33.8 ml) at room temperature, followed by the addition of CsF (2.053 g, 13.51 mmol). The reaction mixture was stirred in air at 110 °C for 20 hours. After completion of the reaction, the reaction was quenched with water at room temperature and extracted with EtOAc. The organic layer was separated, washed sequentially with water and brine, dried over anhydrous Na2SO4 and subsequently concentrated under reduced pressure. Purification of the residue by column chromatography (silica gel as stationary phase and EtOAc in hexane as eluent) afforded 2-fluoro-3-cyanopyridine (0.639 g, 4.86 mmol, 71.9% yield) as a colorless oil. Compounds 3B'-8B' were prepared by a method similar to the synthetic procedure described above for 2B'.

References

[1] European Journal of Inorganic Chemistry, 2017, vol. 2017, # 2, p. 330 - 339
[2] Tetrahedron Letters, 2015, vol. 56, # 44, p. 6043 - 6046
[3] Heterocycles, 1992, vol. 34, # 8, p. 1507 - 1510
[4] Organic Letters, 2015, vol. 17, # 8, p. 1866 - 1869
[5] Journal of Organic Chemistry, 2015, vol. 80, # 24, p. 12137 - 12145

3-Cyano-2-fluoropyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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3-Cyano-2-fluoropyridine Suppliers

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View Lastest Price from 3-Cyano-2-fluoropyridine manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
3-Cyano-2-fluoropyridine 3939-13-7
Price
US $1.10/g
Min. Order
1g
Purity
99.0% min
Supply Ability
100 tons min
Release date
2021-04-30
Zhuozhou Wenxi import and Export Co., Ltd
Product
3-Cyano-2-fluoropyridine 3939-13-7
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11
Career Henan Chemical Co
Product
3-Cyano-2-fluoropyridine 3939-13-7
Price
US $9.80/KG
Min. Order
1KG
Purity
≥98%
Supply Ability
20 tons
Release date
2020-01-10

3939-13-7, 3-Cyano-2-fluoropyridineRelated Search:

3-Hydroxypyridine 3-Cyanopyridine 2-Chloro-3-cyanopyridine 2-Fluoropyridine Flupirtine Methylene dithiocyanate 3-Aminopyridine ETHYL 2-CYANOACRYLATE 2-Cyano-6-fluoropyridine 3-Fluoropyridine-4-carbonitrile 2,6-Dichloro-5-fluoro-3-pyridinecarbonitrile 2-Chloro-5-cyano-3-fluoropyridine 2-Fluoro-3-methylpyridine 4-CYANO-2-FLUOROPYRIDINE 2-CYANO-3-FLUOROPYRIDINE,2-CYANO-3-FLUOROPYRIDINE,3-FLUORO-2-PYRIDINECARBONITRILE,2-Cyano-3-fluoropyridine, 97+% 5-Cyano-2-fluoropyridine 2-Cyano-4-fluoropyridine 3-CYANO-5-FLUOROPYRIDINE

  • 3-CYANO-2-FLUOROPYRIDINE
  • 2-FLUOROPYRIDINE-3-CARBONITRILE
  • 2-FLUORO-3-PYRIDINECARBONITRILE
  • 2-FLUORO-3-CYANOPYRIDINE
  • 2-Fluoronicotinonitrile
  • 3-Cyano-4-fluoropyridine
  • 3-Fluoro-4-cyanopyridine
  • 4-Fluoro-nicotinonitrile
  • 3-Cyano-2-fluoropyri
  • 2-Fluoro-3-cyanopridine
  • 2-Fluoropyridine-3-carbonitrile, 3-Cyano-2-fluoropyridine
  • 3-Cyano-2-fluoropyridine SynonyM 2-Fluoropyridine-3-carbonitrile
  • 3-Cyano-2-fluoropyridine,98%
  • 3-Cyano-2-fluoropyridine &gt
  • 3-Pyridinecarbonitrile, 2-fluoro-
  • 3-Cyano-2-fluoropyridine ISO 9001：2015 REACH
  • 3939-13-7
  • C6H3N2F
  • C6H3FN2
  • pyridine series
  • Pyridine
  • Pyridines