MS436

Product Name: MS436
CAS No.: 1395084-25-9
Chemical Name: MS436
Synonyms: MS436;CS-1882;MS436(95%);MS 436, >=98%;MS-436; MS 436;MS436 USP/EP/BP;5-Dimethoxy-4-hydroxy cinnamaldehyde;(E)-4-[2-(2-Amino-4-hydroxy-5-methylphenyl)diazenyl]-N-2-pyridinylbenzenesulfonamide;(E)-4-((2-AMINO-4-HYDROXY-5-METHYLPHENYL)DIAZENYL)-N-(PYRIDIN-2-YL)BENZENESULFONAMIDE;4-[(1E)-2-(2-Amino-4-hydroxy-5-methylphenyl)diazenyl]-N-2-pyridinylbenzenesulfonamide
CBNumber: CB12677056
Molecular Formula: C18H17N5O3S
Formula Weight: 383.42
MOL File: 1395084-25-9.mol

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MS436 Property

Boiling point:: 673.7±65.0 °C(Predicted)
Density: 1.42±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: insoluble in H2O; insoluble in EtOH; ≥19.15 mg/mL in DMSO
form: solid
pka: 9.25±0.36(Predicted)
color: Pink to red

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 5173
Product name: MS436
Purity: ≥98%(HPLC)
Packaging: 10
Price: $184
Updated: 2021/12/16

Tocris

Product number: 5173
Product name: MS436
Purity: ≥98%(HPLC)
Packaging: 50
Price: $753
Updated: 2021/12/16

TRC

Product number: A612095
Product name: 4-[(1E)-2-(2-Amino-4-hydroxy-5-methylphenyl)diazenyl]-N-2-pyridinylbenzenesulfonamide
Packaging: 10mg
Price: $185
Updated: 2021/12/16

AK Scientific

Product number: Y1865
Product name: MS436
Packaging: 10mg
Price: $218.75
Updated: 2021/12/16

ChemScene

Product number: CS-1729
Product name: MS436
Purity: 99.13%
Packaging: 5mg
Price: $90
Updated: 2021/12/16

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MS436 Chemical Properties,Usage,Production

Description

MS436, through a set of water-mediated interactions, exhibits low nanomolar affinity (estimated Ki of 30-50 nM) with preference for the first bromodomain over the second. MS436 effectively blocks BRD4 transcriptional activity in lipopolysaccharide-induced production of both nitric oxide and IL-6 in mouse macrophages (IC50 values are 3.8 and 4.9 ?M, respectively). MS436 represents a new class of bromodomain inhibitors and will facilitate further investigation of the biological functions of the two bromodomains of BRD4 in gene expression.

Uses

MS 436 is a potent bromodomain inhibitor, binding to BRD4 and more tightly to subdomain BD1 than BD2. These domains play a key role in inflammatory gene expression, mitosis and viral/host interaction. Applications involving innhibition of bromodomains include decrease in cell proliferation for leukemia and destruction of tumor cells.

Biological Activity

ms436 is a potent and selective small-molecule inhibitor of brd4 with ki values of ＜0.085μm and 0.34μm, respectively for brd1 and brd2 [1].brd4 plays a role in gene transcription and is a drug target for cancer and inflammation. it has two bromodomains. ms436 is a diazobenzene compound, it is designed from the sar studies to have higher selectivity. in vitro fluorescent anisotropy assay shows ms436 has about 10-fold higher affinity of brd1 over brd2. ms436 binds to brd4 through a set of water-mediated interaction and this is the molecular basis for the binding affinity. ms436 also has activity to cbp brd. in raw264.7 cells, ms436 can block nf-κb-directed no production and block the expression of proinflammatory cytokine interleukin (il)-6 induced by lps [1].

storage

-20°C

References

[1] zhang g, plotnikov an, rusinova e, shen t, morohashi k, joshua j, zeng l, mujtaba s, ohlmeyer m, zhou mm. structure-guided design of potent diazobenzene inhibitors for the bet bromodomains. j med chem. 2013 nov 27;56(22):9251-64.

MS436 Preparation Products And Raw materials

Raw materials

Preparation Products

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MS436 Suppliers

China 85 India 2 United Kingdom 1 United States 11 Global 99

MedChemexpress LLC

Tel: 021-58955995
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Target molecule Corp.

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Musechem

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TargetMol Chemicals Inc.

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InvivoChem

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BOC Sciences

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Aladdin Scientific

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ApexBio Technology

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MedChemExpress

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Cayman Chemical Company

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View Lastest Price from MS436 manufacturers

Career Henan Chemical Co

Product: (E)-4-((2-AMINO-4-HYDROXY-5-METHYLPHENYL)DIAZENYL)-N-(PYRIDIN-2-YL)BENZENESULFONAMIDE 1395084-25-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 20kg
Release date: 2019-09-03

1395084-25-9, MS436Related Search:

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(E)-4-[2-(2-Amino-4-hydroxy-5-methylphenyl)diazenyl]-N-2-pyridinylbenzenesulfonamide

MS-436; MS 436

4-[(2Z)-2-(2-amino-5-methyl-4-oxocyclohexa-2,5-dien-1-ylidene)hydrazinyl]-N-pyridin-2-ylbenzenesulfonamide

CS-1882

MS436(95%)

4-[(1E)-2-(2-Amino-4-hydroxy-5-methylphenyl)diazenyl]-N-2-pyridinylbenzenesulfonamide

4-[(1E)-2-(2-Amino-4-hydroxy-5-methylphenyl)diazenyl]-N-2-pyridinylbenzenesulfonamide MS436

MS436 4-[(1E)-2-(2-Amino-4-hydroxy-5-methylphenyl)diazenyl]-N-2-pyridinylbenzenesulfonamide

MS 436, >=98%

MS436

(E)-4-((2-AMINO-4-HYDROXY-5-METHYLPHENYL)DIAZENYL)-N-(PYRIDIN-2-YL)BENZENESULFONAMIDE

Benzenesulfonamide, 4-[(1E)-2-(2-amino-4-hydroxy-5-methylphenyl)diazenyl]-N-2-pyridinyl-

MS436 USP/EP/BP

5-Dimethoxy-4-hydroxy cinnamaldehyde

1395084-25-9

395084-25-9

Inhibitors