ChemicalBook > CAS DataBase List > Ilaprazole sodium

Ilaprazole sodium

Product Name: Ilaprazole sodium
CAS No.: 172152-50-0
Chemical Name: Ilaprazole sodium
Synonyms: IY-81149 sodium;Alprazole Sodium;Ilaprazole sodium;Sodium ilaprazole;Ilaprazole Sodium Salt;Ilaprazole Base/Sodium;Ilaprazole sodium USP/EP/BP;Ilaprazole sodium, 10 mM in DMSO;2-(((4-Methoxy-3-methylpyridin-2-yl)methyl)sulfinyl)-6-(1H-pyrrol-1-yl)-1H-benzo[d]imidazole sodium salt;oral,Ilaprazole,acid,ulcers,IY 81149,inhibit,IY-81149,TOPK,gastric,Inhibitor,cancer,Ilaprazole sodium,IY81149,pump,Proton Pump
CBNumber: CB12748578
Molecular Formula: C19H19N4NaO2S
Formula Weight: 390.44
MOL File: 172152-50-0.mol

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Ilaprazole sodium Property

storage temp.: 4°C, protect from light
form: Solid
color: White to off-white
InChI: InChI=1S/C19H18N4O2S.Na.H/c1-13-17(20-8-7-18(13)25-2)12-26(24)19-21-15-6-5-14(11-16(15)22-19)23-9-3-4-10-23;;/h3-11H,12H2,1-2H3,(H,21,22);;
InChIKey: VZAVMHHKFOFGOE-UHFFFAOYSA-N
SMILES: S(C1=NC2=CC=C(N3C=CC=C3)C=C2N1)(=O)CC1N=CC=C(OC)C=1C.[NaH]
CAS DataBase Reference: 172152-50-0

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0020299
Product name: Ilaprazole(sodium)
Purity: 98.50%
Packaging: 5mg
Price: $80
Updated: 2021/12/16

ChemScene

Product number: CS-0020299
Product name: Ilaprazole(sodium)
Purity: 98.50%
Packaging: 10mg
Price: $110
Updated: 2021/12/16

ChemScene

Product number: CS-0020299
Product name: Ilaprazole(sodium)
Purity: 98.50%
Packaging: 25mg
Price: $220
Updated: 2021/12/16

ChemScene

Product number: CS-0020299
Product name: Ilaprazole(sodium)
Purity: 98.50%
Packaging: 50mg
Price: $380
Updated: 2021/12/16

ChemScene

Product number: CS-0020299
Product name: Ilaprazole(sodium)
Purity: 98.50%
Packaging: 100mg
Price: $650
Updated: 2021/12/16

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Ilaprazole sodium Chemical Properties,Usage,Production

Uses

After oral administration, Ilaprazole sodium selectively enters the gastric parietal cells and is converted into an active metabolite of sulfenamide, which interacts with the sulfhydryl group on the H+/K+-ATPase to form a covalent combination of disulfide bonds, irreversibly inhibiting H+/K+- ATPase, which inhibits gastric acid secretion.

in vitro

On cumulation of 14C-aminopyrine in histamine stimulated parietal cells, the IC ₅₀ of Ilaprazole (IY-81149) sodium is 9 nM.

in vivo

Ilaprazole sodium (3-30 mg/kg; i.d.) dose-dependently inhibits gastric acid secretion^[1].
In anesthetized rats, Ilaprazole sodium dose-dependently increases gastric pH which is lowered by histamine infusion. In the case of i.v. injection, the ED₅₀ of Ilaprazole sodium and Omeprazole is 1.2 and 1.4 mg/kg and in the case of i.d. administration, the ED₅₀ of Ilaprazole sodium and omeprazole is 3.9 and 4.1 mg/kg, respectively. Ilaprazole sodium also significantly inhibits pentagastrin-stimulated gastric secretion. Its ED₅₀ is 2.1 mg/kg and that of Omeprazole was 3.5 mg/kg with i.d. administration. In the case of i.v. injection, Ilaprazole sodium is equipotent to Omeprazole. Ilaprazole sodium also inhibits gastric acid secretion strongly in fistular rats. The ED₅₀ of Ilaprazole sodium administered intraduodenally is 0.43 mg/kg and that of omeprazole Is 0.68 mg/kg^[1].

Animal Model:	Male SD rat (after pylorus ligation)^[1]
Dosage:	3, 10, 30 mg/kg
Administration:	Intraduodenally
Result:	The acid output and volume significantly inhibited by about 60 % and 46 % at 3 mg/kg were s, respectively. At 30 mg/kg, it showed 93 % and 73 % inhibition on acid output and volume, respectively.

target

Target	Value
Proton pump ()
H(+) /K(+)-ATPase (in rabbit parietal cell preparation)	6 μM

Ilaprazole sodium Preparation Products And Raw materials

Raw materials

Preparation Products

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Ilaprazole sodium Suppliers

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View Lastest Price from Ilaprazole sodium manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: Ilaprazole sodium 172152-50-0
Price: US $2.00-5.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-06-20

Moxin Chemicals

Product: Ilaprazole(Sodium salt) 172152-50-0
Price: US $0.00-0.00/mg
Min. Order: 10mg
Purity: 98
Supply Ability: 100000
Release date: 2025-02-13

Shaanxi Dideu New Materials Co. Ltd

Product: Ilaprazole sodium 172152-50-0
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-03-10

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Ilaprazole sodium

IY-81149 sodium

Ilaprazole sodium USP/EP/BP

Sodium ilaprazole

oral,Ilaprazole,acid,ulcers,IY 81149,inhibit,IY-81149,TOPK,gastric,Inhibitor,cancer,Ilaprazole sodium,IY81149,pump,Proton Pump

Ilaprazole Sodium Salt

Ilaprazole sodium, 10 mM in DMSO

Ilaprazole Base/Sodium

Alprazole Sodium

2-(((4-Methoxy-3-methylpyridin-2-yl)methyl)sulfinyl)-6-(1H-pyrrol-1-yl)-1H-benzo[d]imidazole sodium salt

172152-50-0

172152-50-5

Inhibitors