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Ilaprazole sodium

Product Name
Ilaprazole sodium
CAS No.
172152-50-0
Chemical Name
Ilaprazole sodium
Synonyms
IY-81149 sodium;Alprazole Sodium;Ilaprazole sodium;Sodium ilaprazole;Ilaprazole Sodium Salt;Ilaprazole Base/Sodium;Ilaprazole sodium USP/EP/BP;Ilaprazole sodium, 10 mM in DMSO;2-(((4-Methoxy-3-methylpyridin-2-yl)methyl)sulfinyl)-6-(1H-pyrrol-1-yl)-1H-benzo[d]imidazole sodium salt;oral,Ilaprazole,acid,ulcers,IY 81149,inhibit,IY-81149,TOPK,gastric,Inhibitor,cancer,Ilaprazole sodium,IY81149,pump,Proton Pump
CBNumber
CB12748578
Molecular Formula
C19H19N4NaO2S
Formula Weight
390.44
MOL File
172152-50-0.mol
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Ilaprazole sodium Property

storage temp. 
4°C, protect from light
form 
Solid
color 
White to off-white
InChI
InChI=1S/C19H18N4O2S.Na.H/c1-13-17(20-8-7-18(13)25-2)12-26(24)19-21-15-6-5-14(11-16(15)22-19)23-9-3-4-10-23;;/h3-11H,12H2,1-2H3,(H,21,22);;
InChIKey
VZAVMHHKFOFGOE-UHFFFAOYSA-N
SMILES
S(C1=NC2=CC=C(N3C=CC=C3)C=C2N1)(=O)CC1N=CC=C(OC)C=1C.[NaH]
CAS DataBase Reference
172152-50-0
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0020299
Product name
Ilaprazole(sodium)
Purity
98.50%
Packaging
5mg
Price
$80
Updated
2021/12/16
ChemScene
Product number
CS-0020299
Product name
Ilaprazole(sodium)
Purity
98.50%
Packaging
10mg
Price
$110
Updated
2021/12/16
ChemScene
Product number
CS-0020299
Product name
Ilaprazole(sodium)
Purity
98.50%
Packaging
25mg
Price
$220
Updated
2021/12/16
ChemScene
Product number
CS-0020299
Product name
Ilaprazole(sodium)
Purity
98.50%
Packaging
50mg
Price
$380
Updated
2021/12/16
ChemScene
Product number
CS-0020299
Product name
Ilaprazole(sodium)
Purity
98.50%
Packaging
100mg
Price
$650
Updated
2021/12/16
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Ilaprazole sodium Chemical Properties,Usage,Production

Uses

After oral administration, Ilaprazole sodium selectively enters the gastric parietal cells and is converted into an active metabolite of sulfenamide, which interacts with the sulfhydryl group on the H+/K+-ATPase to form a covalent combination of disulfide bonds, irreversibly inhibiting H+/K+- ATPase, which inhibits gastric acid secretion.

in vitro

On cumulation of 14C-aminopyrine in histamine stimulated parietal cells, the IC 50 of Ilaprazole (IY-81149) sodium is 9 nM.

in vivo

Ilaprazole sodium (3-30 mg/kg; i.d.) dose-dependently inhibits gastric acid secretion[1].
In anesthetized rats, Ilaprazole sodium dose-dependently increases gastric pH which is lowered by histamine infusion. In the case of i.v. injection, the ED50 of Ilaprazole sodium and Omeprazole is 1.2 and 1.4 mg/kg and in the case of i.d. administration, the ED50 of Ilaprazole sodium and omeprazole is 3.9 and 4.1 mg/kg, respectively. Ilaprazole sodium also significantly inhibits pentagastrin-stimulated gastric secretion. Its ED50 is 2.1 mg/kg and that of Omeprazole was 3.5 mg/kg with i.d. administration. In the case of i.v. injection, Ilaprazole sodium is equipotent to Omeprazole. Ilaprazole sodium also inhibits gastric acid secretion strongly in fistular rats. The ED50 of Ilaprazole sodium administered intraduodenally is 0.43 mg/kg and that of omeprazole Is 0.68 mg/kg[1].

Animal Model:Male SD rat (after pylorus ligation)[1]
Dosage:3, 10, 30 mg/kg
Administration:Intraduodenally
Result:The acid output and volume significantly inhibited by about 60 % and 46 % at 3 mg/kg were s, respectively. At 30 mg/kg, it showed 93 % and 73 % inhibition on acid output and volume, respectively.

target

TargetValue
Proton pump
()
H(+) /K(+)-ATPase
(in rabbit parietal cell preparation)		 6 μM

Ilaprazole sodium Preparation Products And Raw materials

Raw materials

Preparation Products

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Ilaprazole sodium Suppliers

China 64 India 1 United States 4 Global 69
Metro Chem Api Private Limited
Tel
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Fax
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Country
India
ProdList
9
Advantage
58
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View Lastest Price from Ilaprazole sodium manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
Ilaprazole sodium 172152-50-0
Price
US $2.00-5.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2025-06-20
Moxin Chemicals
Product
Ilaprazole(Sodium salt) 172152-50-0
Price
US $0.00-0.00/mg
Min. Order
10mg
Purity
98
Supply Ability
100000
Release date
2025-02-13
Shaanxi Dideu New Materials Co. Ltd
Product
Ilaprazole sodium 172152-50-0
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10000KGS
Release date
2025-03-10

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  • IY-81149 sodium
  • Ilaprazole sodium USP/EP/BP
  • Sodium ilaprazole
  • oral,Ilaprazole,acid,ulcers,IY 81149,inhibit,IY-81149,TOPK,gastric,Inhibitor,cancer,Ilaprazole sodium,IY81149,pump,Proton Pump
  • Ilaprazole Sodium Salt
  • Ilaprazole sodium, 10 mM in DMSO
  • Ilaprazole Base/Sodium
  • Alprazole Sodium
  • 2-(((4-Methoxy-3-methylpyridin-2-yl)methyl)sulfinyl)-6-(1H-pyrrol-1-yl)-1H-benzo[d]imidazole sodium salt
  • 172152-50-0
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  • Inhibitors