ANTIPAIN, DIHYDROCHLORIDE

Product Name: ANTIPAIN, DIHYDROCHLORIDE
CAS No.: 37682-72-7
Chemical Name: ANTIPAIN, DIHYDROCHLORIDE
Synonyms: ANTIPAIN;BDBM32804;BDBM 32804;BDBM-32804;Antipain HCl;Antipain 2HCI;ANTIPAIN (2HCL);BDBM 32804, Antipain;ANTIPAIN HYDROCHLORIDE;Phe-Arg-Val-Arg-CHO.2HCl
CBNumber: CB1279463
Molecular Formula: C27H46Cl2N10O6
Formula Weight: 677.62
MOL File: 37682-72-7.mol

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ANTIPAIN, DIHYDROCHLORIDE Property

Melting point:: 209-217 °C
Boiling point:: 652.92°C (rough estimate)
Density: 1.2423 (rough estimate)
refractive index: 1.6500 (estimate)
storage temp.: -20°C
solubility: H₂O: 50 mg/mL
form: White powder
color: White
Water Solubility: 0.01M in water
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 1 month.

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Safety

Safety Statements: 22-24/25
WGK Germany: 3
RTECS: YV9350800
F: 1-10
HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 178220
Product name: Antipain, Hydrochloride
Packaging: 5mg
Price: $85.2
Updated: 2024/03/01

Sigma-Aldrich

Product number: 178220
Product name: Antipain, Hydrochloride
Packaging: 10mg
Price: $144
Updated: 2024/03/01

Sigma-Aldrich

Product number: 11004646001
Product name: Antipain dihydrochloride
Packaging: 10mg
Price: $244
Updated: 2024/03/01

Alfa Aesar

Product number: J63680
Product name: Antipain dihydrochloride
Packaging: 5mg
Price: $73.65
Updated: 2024/03/01

Cayman Chemical

Product number: 26705
Product name: Antipain (hydrochloride)
Packaging: 5mg
Price: $43
Updated: 2024/03/01

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ANTIPAIN, DIHYDROCHLORIDE Chemical Properties,Usage,Production

Description

Antipain is a protease inhibitor originally isolated from actinomycetes. It inhibits thrombokinase, plasmin, trypsin, and papain in vitro (IC₅₀s = 20, 93, 0.26, and 0.16 μg/ml, respectively). Antipain (6-600 μg/ml) inhibits the morphological transformation of and increases frequency of chromosomal aberrations in Syrian hamster embryo cells induced by N-methyl-N''-nitro-N-nitroso-guanidine (MNNG). In vivo, antipain (25-100 mg/kg) suppresses urethan-induced formation of cleft palates and cleft lips in mice.

Uses

Concentrations for 50% inhibition (μg/ml): papain, 0.16trypsin, 0.26cathepsin A, 1.19cathepsin B, 0.59cathepsin D, 125plasmin, >93chymotrypsin and pepsin, >250It also has been reported to inhibit calpain I, (porcine) with Ki = 1.4 μM

Uses

Antipain inhibits trypsin, papain, and catherpsins A and B (a reversible inhibitor of cysteine and serine proteases). It is used to evaluate the role of proteases in cell transformations. It is used to help identify new proteases.

General Description

Antipain is a protease inhibitor isolated from actinomycetes. It inhibits thrombokinase and blood coagulation.

Biochem/physiol Actions

Reversible inhibitor of serine/cysteine proteases and some trypsin-like serine proteases. Its action resembles leupeptin; however, its plasmin inhibition is less and its cathepsin A inhibition is more than that observed with leupeptin. Chronic administration of antipain can reduce the frequency of chemically induced transformation in BALB/c-/3T3 cells.

References

1) Umezawa?et al.?(1976),?Structures and activities of protease inhibitors of microbial origin; Method Enzymol.,?45?678 2) Gotoh?et al.?(2001),?Proteolytic activity and recombinant protein production in virus-infected Sf-9 insect cell cultures supplemented with carboxyl and cysteine protease inhibitors; J. Biosci. Bioeng.,?92?248 3) Hockensmith?et al. (2016), Identification and characterization of a chymotrypsin-like serine protease from periodontal pathogen, Tannerella forsythia; Microb. Pathog.,?100?37 4) Mat Amin?et al. (2004),?Proteinases in Naegleria Fowleri (strain NF3), a pathogenic amoeba: a preliminary study.; Trop. Biomed.,?21?57 5) Moriyyasu & Inoue (2008),?Use of protease inhibitor for detecting autophagy in plants; Methods Enzymol.,?451?557

ANTIPAIN, DIHYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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ANTIPAIN, DIHYDROCHLORIDE Suppliers

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Sigma-Aldrich

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37682-72-7, ANTIPAIN, DIHYDROCHLORIDERelated Search:

Pectinase Acetyl coenzyme A sodium salt HEXOKINASE alpha-Amylase PROTEASE Chymotrypsin α-Amylase EC 2.6.1.2 D-AMINO ACID OXIDASE Pepsin β-Amylase DISPASE Glucose oxidase N-1-naphthylethylenediamine hydrochloride Clindamycin hydrochloride ANTIPAIN HYDROCHLORIDE DIHYDRATE ANTIPAIN, DIHYDROCHLORIDE ANTIPAIN MONOHYDROCHLORIDE DIHYDRATE

ANTIPAIN

ANTIPAIN (2HCL)

ANTIPAIN, DIHYDROCHLORIDE

ANTIPAIN HYDROCHLORIDE

[(S)-I-CARBOXY-2-PHENYLETHYL]-CARBAMOYL-L-ARG-L-VAL-ARGINAL

[(S)-1-CARBOXY-2-PHENETHYL]-CARBAMOYL-ARG-VAL-ARG-ALDEHYDE

(S)-[1-CARBOXY-2-PHENYL-ETHYL]-CARBAMOYL-ARG-VAL-ARG-ALDEHYDE

[(S)-1-CARBOXY-2-PHENYLETHYL]-CARBAMOYL-ARG-VAL-ARG-AL HYDROCHLORIDE

[(S)-1-CARBOXY-2-PHENYLETHYL]-CARBAMOYL-ARG-VAL-ARGINAL 2HCL

[(S)-1-CARBOXY-2-PHENYLETHYL]-CARBAMOYL-ARG-VAL-L-ARGININAL

[(S)-1-CARBOXY-2-PHENYLETHYL]CARBAMOYL-L-ARGINYL-L-VALYL-ARGININAL

[(S)-1-CARBOXY-2-PHENYLETHYL]CARBAMOYL-L-ARGINYL-L-VALYLARGININAL HYDROCHLORIDE

N-(-N-ALPHA-CARBONYL-ARG-VAL-ARG-AL)PHE

N-[-N-ALPHA-CARBONYL-ARG-VAL-ARG-AL]-PHE HCL

N-[-N-ALPHA-CARBONYL-ARG-VAL-ARG-AL]-PHE HYDROCHLORIDE

l-valinamide,n(sup2)-(((1-carboxy-2-phenylethyl)amino)carbonyl)-l-arginyl-n-(

ANTIPAIN HYDROCHLORIDE FROMMICROBIAL SOU RCE

L-Valinamide, N2-(1-carboxy-2-phenylethyl)aminocarbonyl-L-arginyl-N-4-(aminoiminomethyl)amino-1-formylbutyl-, dihydrochloride

antipain dihydrochloride from microbial source

n-(nα-carbonyl-arg-val-arg-al)-phe

N-(N-Carbonyl-Arg-Val-Arg-al)-Phe dihydrochloride

TRIS-GLYCINE BUFFER 10X PWD PROTEOMICS

N2-[[[(1S)-1-Carboxy-2-phenylethyl]amino]carbonyl]-L-arginyl-N-[4-[(aminoiminomethyl)amino]-1-formylbutyl]-L-valinamide hydrochloride (1:2)

Antipain 2HCI

L-Valinamide, N(sup 2)-(((1-carboxy-2-phenylethyl)amino)carbonyl)-L-arginyl-N-(4-((aminoiminomethyl)amino)-1-formylbutyl)-, dihydrochloride

Phe-Arg-Val-Arg-CHO.2HCl

ANTIPAIN ;PHE-ARG-VAL-ARG-CHO.2HCL

(9S,12S)-1-aMino-16-benzyl-6-forMyl-12-(3-guanidinopropyl)-1-iMino-9-isopropyl-8,11,14-trioxo-2,7,10,13,15-pentaazaheptadecan-17-oic acid dihydrochloride

L-Valinamide,N2-[[[(1S)-1-carboxy-2-phenylethyl]amino]carbonyl]-L-arginyl-N-[4-[(aminoiminomethyl)amino]-1-formylbutyl]-,hydrochloride (1:2)

EZNA KIT ISOLATION FFPE RNA

Antipain, Dihydrochloride - CAS 37682-72-7 - Calbiochem

Antipain, Hydrochloride - CAS 37682-72-7 - Calbiochem

Antipain dihydrochloride from microbial source protease inhibitor

Antipain HCl

BDBM 32804

BDBM32804

BDBM-32804

BDBM 32804, Antipain

Antipain 2HCl|||BDBM-32804|||BDBM 32804, Antipain|||BDBM32804

37682-72-7

C27H44N10O62HCl

C27H44N10O62ClH

C27H46Cl2N10O6

BioChemical

Biochemicals and Reagents

Antibiotics

Analytical Enzymes

Antibiotics A to Z

Antibiotics A-F

Enzymes, Inhibitors, and Substrates

Trypsin Inhibitors

peptides

inhibitor

AN-AZ

Antineoplastic and Immunosuppressive Antibiotics

Broad Spectrum Inhibitors of Proteolytic Enzyme Classes

Cathepsin D

Cysteine Protease Inhibitor