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ANTIPAIN, DIHYDROCHLORIDE

Product Name
ANTIPAIN, DIHYDROCHLORIDE
CAS No.
37682-72-7
Chemical Name
ANTIPAIN, DIHYDROCHLORIDE
Synonyms
ANTIPAIN;BDBM32804;BDBM 32804;BDBM-32804;Antipain HCl;Antipain 2HCI;ANTIPAIN (2HCL);BDBM 32804, Antipain;ANTIPAIN HYDROCHLORIDE;Phe-Arg-Val-Arg-CHO.2HCl
CBNumber
CB1279463
Molecular Formula
C27H46Cl2N10O6
Formula Weight
677.62
MOL File
37682-72-7.mol
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ANTIPAIN, DIHYDROCHLORIDE Property

Melting point:
209-217 °C
Boiling point:
652.92°C (rough estimate)
Density 
1.2423 (rough estimate)
refractive index 
1.6500 (estimate)
storage temp. 
-20°C
solubility 
H2O: 50 mg/mL
form 
White powder
color 
White
Water Solubility 
0.01M in water
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 1 month.
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
RTECS 
YV9350800
F 
1-10
HS Code 
2934999090
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
178220
Product name
Antipain, Hydrochloride
Packaging
5mg
Price
$85.2
Updated
2024/03/01
Sigma-Aldrich
Product number
178220
Product name
Antipain, Hydrochloride
Packaging
10mg
Price
$144
Updated
2024/03/01
Sigma-Aldrich
Product number
11004646001
Product name
Antipain dihydrochloride
Packaging
10mg
Price
$244
Updated
2024/03/01
Alfa Aesar
Product number
J63680
Product name
Antipain dihydrochloride
Packaging
5mg
Price
$73.65
Updated
2024/03/01
Cayman Chemical
Product number
26705
Product name
Antipain (hydrochloride)
Packaging
5mg
Price
$43
Updated
2024/03/01
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ANTIPAIN, DIHYDROCHLORIDE Chemical Properties,Usage,Production

Description

Antipain is a protease inhibitor originally isolated from actinomycetes. It inhibits thrombokinase, plasmin, trypsin, and papain in vitro (IC50s = 20, 93, 0.26, and 0.16 μg/ml, respectively). Antipain (6-600 μg/ml) inhibits the morphological transformation of and increases frequency of chromosomal aberrations in Syrian hamster embryo cells induced by N-methyl-N''-nitro-N-nitroso-guanidine (MNNG). In vivo, antipain (25-100 mg/kg) suppresses urethan-induced formation of cleft palates and cleft lips in mice.

Uses

Concentrations for 50% inhibition (μg/ml): papain, 0.16trypsin, 0.26cathepsin A, 1.19cathepsin B, 0.59cathepsin D, 125plasmin, >93chymotrypsin and pepsin, >250It also has been reported to inhibit calpain I, (porcine) with Ki = 1.4 μM

Uses

Antipain inhibits trypsin, papain, and catherpsins A and B (a reversible inhibitor of cysteine and serine proteases). It is used to evaluate the role of proteases in cell transformations. It is used to help identify new proteases.

General Description

Antipain is a protease inhibitor isolated from actinomycetes. It inhibits thrombokinase and blood coagulation.

Biochem/physiol Actions

Reversible inhibitor of serine/cysteine proteases and some trypsin-like serine proteases. Its action resembles leupeptin; however, its plasmin inhibition is less and its cathepsin A inhibition is more than that observed with leupeptin. Chronic administration of antipain can reduce the frequency of chemically induced transformation in BALB/c-/3T3 cells.

References

1) Umezawa?et al.?(1976),?Structures and activities of protease inhibitors of microbial origin; Method Enzymol.,?45?678 2) Gotoh?et al.?(2001),?Proteolytic activity and recombinant protein production in virus-infected Sf-9 insect cell cultures supplemented with carboxyl and cysteine protease inhibitors; J. Biosci. Bioeng.,?92?248 3) Hockensmith?et al. (2016), Identification and characterization of a chymotrypsin-like serine protease from periodontal pathogen, Tannerella forsythia; Microb. Pathog.,?100?37 4) Mat Amin?et al. (2004),?Proteinases in Naegleria Fowleri (strain NF3), a pathogenic amoeba: a preliminary study.; Trop. Biomed.,?21?57 5) Moriyyasu & Inoue (2008),?Use of protease inhibitor for detecting autophagy in plants; Methods Enzymol.,?451?557

ANTIPAIN, DIHYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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ANTIPAIN, DIHYDROCHLORIDE Suppliers

China 63 Europe 1 France 1 Germany 6 India 1 Japan 3 Switzerland 2 The Netherlands 1 United Kingdom 5 United States 22 Global 105
AppliChem GmbH
Tel
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Fax
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Email
service@applichem.de
Country
Germany
ProdList
968
Advantage
65
Service Chemical Inc.
Tel
--
Fax
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Email
sales@chemos-group.com
Country
Germany
ProdList
6350
Advantage
71
SERVA Electrophoresis GmbH
Tel
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Fax
--
Email
info@serva.de
Country
Germany
ProdList
1142
Advantage
80
AppliChem GmbH
Tel
--
Fax
--
Email
service@applichem.de
Country
Germany
ProdList
1607
Advantage
74
BIOTREND Chemikalien GmbH
Tel
--
Fax
--
Email
jaeger@biotrend.com
Country
Germany
ProdList
6115
Advantage
76
Biomol Feinchemikalien GmbH
Tel
--
Fax
--
Email
info@biomol.de
Country
Germany
ProdList
479
Advantage
74

37682-72-7, ANTIPAIN, DIHYDROCHLORIDERelated Search:

Pectinase Acetyl coenzyme A sodium salt HEXOKINASE alpha-Amylase PROTEASE Chymotrypsin α-Amylase EC 2.6.1.2 D-AMINO ACID OXIDASE Pepsin β-Amylase DISPASE Glucose oxidase N-1-naphthylethylenediamine hydrochloride Clindamycin hydrochloride ANTIPAIN HYDROCHLORIDE DIHYDRATE ANTIPAIN, DIHYDROCHLORIDE ANTIPAIN MONOHYDROCHLORIDE DIHYDRATE

  • ANTIPAIN
  • ANTIPAIN (2HCL)
  • ANTIPAIN, DIHYDROCHLORIDE
  • ANTIPAIN HYDROCHLORIDE
  • [(S)-I-CARBOXY-2-PHENYLETHYL]-CARBAMOYL-L-ARG-L-VAL-ARGINAL
  • [(S)-1-CARBOXY-2-PHENETHYL]-CARBAMOYL-ARG-VAL-ARG-ALDEHYDE
  • (S)-[1-CARBOXY-2-PHENYL-ETHYL]-CARBAMOYL-ARG-VAL-ARG-ALDEHYDE
  • [(S)-1-CARBOXY-2-PHENYLETHYL]-CARBAMOYL-ARG-VAL-ARG-AL HYDROCHLORIDE
  • [(S)-1-CARBOXY-2-PHENYLETHYL]-CARBAMOYL-ARG-VAL-ARGINAL 2HCL
  • [(S)-1-CARBOXY-2-PHENYLETHYL]-CARBAMOYL-ARG-VAL-L-ARGININAL
  • [(S)-1-CARBOXY-2-PHENYLETHYL]CARBAMOYL-L-ARGINYL-L-VALYL-ARGININAL
  • [(S)-1-CARBOXY-2-PHENYLETHYL]CARBAMOYL-L-ARGINYL-L-VALYLARGININAL HYDROCHLORIDE
  • N-(-N-ALPHA-CARBONYL-ARG-VAL-ARG-AL)PHE
  • N-[-N-ALPHA-CARBONYL-ARG-VAL-ARG-AL]-PHE HCL
  • N-[-N-ALPHA-CARBONYL-ARG-VAL-ARG-AL]-PHE HYDROCHLORIDE
  • l-valinamide,n(sup2)-(((1-carboxy-2-phenylethyl)amino)carbonyl)-l-arginyl-n-(
  • ANTIPAIN HYDROCHLORIDE FROMMICROBIAL SOU RCE
  • L-Valinamide, N2-(1-carboxy-2-phenylethyl)aminocarbonyl-L-arginyl-N-4-(aminoiminomethyl)amino-1-formylbutyl-, dihydrochloride
  • antipain dihydrochloride from microbial source
  • n-(nα-carbonyl-arg-val-arg-al)-phe
  • N-(N-Carbonyl-Arg-Val-Arg-al)-Phe dihydrochloride
  • TRIS-GLYCINE BUFFER 10X PWD PROTEOMICS
  • N2-[[[(1S)-1-Carboxy-2-phenylethyl]amino]carbonyl]-L-arginyl-N-[4-[(aminoiminomethyl)amino]-1-formylbutyl]-L-valinamide hydrochloride (1:2)
  • Antipain 2HCI
  • L-Valinamide, N(sup 2)-(((1-carboxy-2-phenylethyl)amino)carbonyl)-L-arginyl-N-(4-((aminoiminomethyl)amino)-1-formylbutyl)-, dihydrochloride
  • Phe-Arg-Val-Arg-CHO.2HCl
  • ANTIPAIN ;PHE-ARG-VAL-ARG-CHO.2HCL
  • (9S,12S)-1-aMino-16-benzyl-6-forMyl-12-(3-guanidinopropyl)-1-iMino-9-isopropyl-8,11,14-trioxo-2,7,10,13,15-pentaazaheptadecan-17-oic acid dihydrochloride
  • L-Valinamide,N2-[[[(1S)-1-carboxy-2-phenylethyl]amino]carbonyl]-L-arginyl-N-[4-[(aminoiminomethyl)amino]-1-formylbutyl]-,hydrochloride (1:2)
  • EZNA KIT ISOLATION FFPE RNA
  • Antipain, Dihydrochloride - CAS 37682-72-7 - Calbiochem
  • Antipain, Hydrochloride - CAS 37682-72-7 - Calbiochem
  • Antipain dihydrochloride from microbial source protease inhibitor
  • Antipain HCl
  • BDBM 32804
  • BDBM32804
  • BDBM-32804
  • BDBM 32804, Antipain
  • Antipain 2HCl|||BDBM-32804|||BDBM 32804, Antipain|||BDBM32804
  • 37682-72-7
  • C27H44N10O62HCl
  • C27H44N10O62ClH
  • C27H46Cl2N10O6
  • BioChemical
  • Biochemicals and Reagents
  • Antibiotics
  • Analytical Enzymes
  • Antibiotics A to Z
  • Antibiotics A-F
  • Enzymes, Inhibitors, and Substrates
  • Trypsin Inhibitors
  • peptides
  • inhibitor
  • AN-AZ
  • Antineoplastic and Immunosuppressive Antibiotics
  • Broad Spectrum Inhibitors of Proteolytic Enzyme Classes
  • Cathepsin D
  • Cysteine Protease Inhibitor