ChemicalBook > CAS DataBase List > ANTIPAIN, DIHYDROCHLORIDE

ANTIPAIN, DIHYDROCHLORIDE

Product Name
ANTIPAIN, DIHYDROCHLORIDE
CAS No.
37682-72-7
Chemical Name
ANTIPAIN, DIHYDROCHLORIDE
Synonyms
ANTIPAIN;BDBM32804;BDBM 32804;BDBM-32804;Antipain HCl;Antipain 2HCI;ANTIPAIN (2HCL);BDBM 32804, Antipain;ANTIPAIN HYDROCHLORIDE;Phe-Arg-Val-Arg-CHO.2HCl
CBNumber
CB1279463
Molecular Formula
C27H46Cl2N10O6
Formula Weight
677.62
MOL File
37682-72-7.mol
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ANTIPAIN, DIHYDROCHLORIDE Property

Melting point:
209-217 °C
Boiling point:
652.92°C (rough estimate)
Density 
1.2423 (rough estimate)
refractive index 
1.6500 (estimate)
storage temp. 
-20°C
solubility 
H2O: 50 mg/mL
form 
White powder
color 
White
biological source
Streptomyces sp.
Water Solubility 
0.01M in water
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 1 month.
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
RTECS 
YV9350800
F 
1-10
HS Code 
2934999090
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
178220
Product name
Antipain, Hydrochloride
Packaging
5mg
Price
$87.9
Updated
2025/07/31
Sigma-Aldrich
Product number
178220
Product name
Antipain, Hydrochloride
Packaging
10mg
Price
$149
Updated
2025/07/31
Sigma-Aldrich
Product number
11004646001
Product name
Antipain dihydrochloride
Packaging
10mg
Price
$249
Updated
2025/07/31
Cayman Chemical
Product number
26705
Product name
Antipain (hydrochloride)
Packaging
5mg
Price
$43
Updated
2024/03/01
Cayman Chemical
Product number
26705
Product name
Antipain (hydrochloride)
Packaging
10mg
Price
$81
Updated
2024/03/01
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ANTIPAIN, DIHYDROCHLORIDE Chemical Properties,Usage,Production

Description

Antipain is a protease inhibitor originally isolated from actinomycetes. It inhibits thrombokinase, plasmin, trypsin, and papain in vitro (IC50s = 20, 93, 0.26, and 0.16 μg/ml, respectively). Antipain (6-600 μg/ml) inhibits the morphological transformation of and increases frequency of chromosomal aberrations in Syrian hamster embryo cells induced by N-methyl-N''-nitro-N-nitroso-guanidine (MNNG). In vivo, antipain (25-100 mg/kg) suppresses urethan-induced formation of cleft palates and cleft lips in mice.

Uses

Concentrations for 50% inhibition (μg/ml): papain, 0.16trypsin, 0.26cathepsin A, 1.19cathepsin B, 0.59cathepsin D, 125plasmin, >93chymotrypsin and pepsin, >250It also has been reported to inhibit calpain I, (porcine) with Ki = 1.4 μM

Uses

Antipain inhibits trypsin, papain, and catherpsins A and B (a reversible inhibitor of cysteine and serine proteases). It is used to evaluate the role of proteases in cell transformations. It is used to help identify new proteases.

General Description

Antipain is a protease inhibitor isolated from actinomycetes. It inhibits thrombokinase and blood coagulation.

Biochem/physiol Actions

Reversible inhibitor of serine/cysteine proteases and some trypsin-like serine proteases. Its action resembles leupeptin; however, its plasmin inhibition is less and its cathepsin A inhibition is more than that observed with leupeptin. Chronic administration of antipain can reduce the frequency of chemically induced transformation in BALB/c-/3T3 cells.

in vivo

The intact, cycling female mice received subcutaneous injections of Antipain dihydrochloride (3 mg) for 16 days, their uteri shows significant diminution in weight and total DNA when compared to untreated controls[4].
Antipain dihydrochloride (100 μg/g body wt; i.p.; at 12h intervals from 0 to 120 h or 240 to 360 h) shows inhibitory effect on Urethane-induced lung neoplasia in mice[5].

References

[1] UMEZAWA H. Structures and activities of protease inhibitors of microbial origin.[J]. Methods in enzymology, 1976, 45: 678-695. DOI:10.1016/s0076-6879(76)45058-9
[2] T GOTOH. Proteolytic activity and recombinant protein production in virus-infected Sf-9 insect cell cultures supplemented with carboxyl and cysteine protease inhibitors.[J]. Journal of bioscience and bioengineering, 2001, 92 3: 248-255. DOI:10.1263/jbb.92.248
[3] K. HOCKENSMITH. Identification and characterization of a chymotrypsin-like serine protease from periodontal pathogen, Tannerella forsythia[J]. Microbial pathogenesis, 2016, 100: Pages 37-42. DOI:10.1016/j.micpath.2016.08.041
[4] AMIN N M. Proteinases in Naegleria Fowleri (strain NF3), a pathogenic amoeba: a preliminary study.[J]. Tropical biomedicine, 2004, 21 2: 57-60.
[5] YUJI MORIYASU  Yuko I. Use of protease inhibitors for detecting autophagy in plants.[J]. Methods in enzymology, 2008, 451: 557-580. DOI:10.1016/s0076-6879(08)03232-1

ANTIPAIN, DIHYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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ANTIPAIN, DIHYDROCHLORIDE Suppliers

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37682-72-7, ANTIPAIN, DIHYDROCHLORIDERelated Search:

Pectinase Acetyl coenzyme A sodium salt HEXOKINASE alpha-Amylase PROTEASE Chymotrypsin α-Amylase EC 2.6.1.2 D-AMINO ACID OXIDASE Pepsin β-Amylase DISPASE Glucose oxidase N-1-naphthylethylenediamine hydrochloride Clindamycin hydrochloride ANTIPAIN HYDROCHLORIDE DIHYDRATE ANTIPAIN, DIHYDROCHLORIDE ANTIPAIN MONOHYDROCHLORIDE DIHYDRATE

  • ANTIPAIN
  • ANTIPAIN (2HCL)
  • ANTIPAIN, DIHYDROCHLORIDE
  • ANTIPAIN HYDROCHLORIDE
  • [(S)-I-CARBOXY-2-PHENYLETHYL]-CARBAMOYL-L-ARG-L-VAL-ARGINAL
  • [(S)-1-CARBOXY-2-PHENETHYL]-CARBAMOYL-ARG-VAL-ARG-ALDEHYDE
  • (S)-[1-CARBOXY-2-PHENYL-ETHYL]-CARBAMOYL-ARG-VAL-ARG-ALDEHYDE
  • [(S)-1-CARBOXY-2-PHENYLETHYL]-CARBAMOYL-ARG-VAL-ARG-AL HYDROCHLORIDE
  • [(S)-1-CARBOXY-2-PHENYLETHYL]-CARBAMOYL-ARG-VAL-ARGINAL 2HCL
  • [(S)-1-CARBOXY-2-PHENYLETHYL]-CARBAMOYL-ARG-VAL-L-ARGININAL
  • [(S)-1-CARBOXY-2-PHENYLETHYL]CARBAMOYL-L-ARGINYL-L-VALYL-ARGININAL
  • [(S)-1-CARBOXY-2-PHENYLETHYL]CARBAMOYL-L-ARGINYL-L-VALYLARGININAL HYDROCHLORIDE
  • N-(-N-ALPHA-CARBONYL-ARG-VAL-ARG-AL)PHE
  • N-[-N-ALPHA-CARBONYL-ARG-VAL-ARG-AL]-PHE HCL
  • N-[-N-ALPHA-CARBONYL-ARG-VAL-ARG-AL]-PHE HYDROCHLORIDE
  • l-valinamide,n(sup2)-(((1-carboxy-2-phenylethyl)amino)carbonyl)-l-arginyl-n-(
  • ANTIPAIN HYDROCHLORIDE FROMMICROBIAL SOU RCE
  • L-Valinamide, N2-(1-carboxy-2-phenylethyl)aminocarbonyl-L-arginyl-N-4-(aminoiminomethyl)amino-1-formylbutyl-, dihydrochloride
  • antipain dihydrochloride from microbial source
  • n-(nα-carbonyl-arg-val-arg-al)-phe
  • N-(N-Carbonyl-Arg-Val-Arg-al)-Phe dihydrochloride
  • N2-[[[(1S)-1-Carboxy-2-phenylethyl]amino]carbonyl]-L-arginyl-N-[4-[(aminoiminomethyl)amino]-1-formylbutyl]-L-valinamide hydrochloride (1:2)
  • Antipain 2HCI
  • L-Valinamide, N(sup 2)-(((1-carboxy-2-phenylethyl)amino)carbonyl)-L-arginyl-N-(4-((aminoiminomethyl)amino)-1-formylbutyl)-, dihydrochloride
  • Phe-Arg-Val-Arg-CHO.2HCl
  • ANTIPAIN ;PHE-ARG-VAL-ARG-CHO.2HCL
  • (9S,12S)-1-aMino-16-benzyl-6-forMyl-12-(3-guanidinopropyl)-1-iMino-9-isopropyl-8,11,14-trioxo-2,7,10,13,15-pentaazaheptadecan-17-oic acid dihydrochloride
  • L-Valinamide,N2-[[[(1S)-1-carboxy-2-phenylethyl]amino]carbonyl]-L-arginyl-N-[4-[(aminoiminomethyl)amino]-1-formylbutyl]-,hydrochloride (1:2)
  • EZNA KIT ISOLATION FFPE RNA
  • Antipain, Dihydrochloride - CAS 37682-72-7 - Calbiochem
  • Antipain, Hydrochloride - CAS 37682-72-7 - Calbiochem
  • Antipain dihydrochloride from microbial source protease inhibitor
  • Antipain HCl
  • BDBM 32804
  • BDBM32804
  • BDBM-32804
  • BDBM 32804, Antipain
  • Antipain 2HCl|||BDBM-32804|||BDBM 32804, Antipain|||BDBM32804
  • TRIS-GLYCINE BUFFER 10X PWD PROTEOMICS
  • L-Valimide,N2-[[[(1S)-1-carboxy-2-phenylethyl]amino]carbonyl]-L-arginyl-N-[4-[(aminoiminomethyl)amino]-1-formylbutyl]-,hydrochloride (1:2)
  • 37682-72-7
  • C27H44N10O62HCl
  • C27H44N10O62ClH
  • C27H46Cl2N10O6
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