ChemicalBook > CAS DataBase List > Ethyl pyrazole-4-carboxylate
Ethyl pyrazole-4-carboxylate
- Product Name
- Ethyl pyrazole-4-carboxylate
- CAS No.
- 37622-90-5
- Chemical Name
- Ethyl pyrazole-4-carboxylate
- Synonyms
- Ethyl 1H-pyrazole-4-carboxylate;ETHYL 4-PYRAZOLECARBOXYLATE;1H-Pyrazole-4-carboxylic acid ethyl ester;ecarboxyL;4-PyrazoL;Regadenoson impurity C;Regadenoson Impurity 7;4- pyrazoleethyl forMate;4-Ethoxycarbonylpyrazole;hylpyrazole-4-Carboxylate
- CBNumber
- CB1294747
- Molecular Formula
- C6H8N2O2
- Formula Weight
- 140.14
- MOL File
- 37622-90-5.mol
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Ethyl pyrazole-4-carboxylate Property
- Melting point:
- 78-80 °C (lit.)
- Boiling point:
- 138-140 °C/3 mmHg (lit.)
- Density
- 1.2850 (rough estimate)
- refractive index
- 1.5010 (estimate)
- Flash point:
- 138-140°C/3mm
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Miscible with acetone.
- form
- Crystalline Powder
- pka
- 11.70±0.50(Predicted)
- color
- White to pale yellow
- InChI
- InChI=1S/C6H8N2O2/c1-2-10-6(9)5-3-7-8-4-5/h3-4H,2H2,1H3,(H,7,8)
- InChIKey
- KACZQOKEFKFNDB-UHFFFAOYSA-N
- SMILES
- N1C=C(C(OCC)=O)C=N1
- LogP
- 0.909 (est)
- CAS DataBase Reference
- 37622-90-5(CAS DataBase Reference)
- NIST Chemistry Reference
- 4-(C2H5COO)-pyrazole(37622-90-5)
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 300780
- Product name
- Ethyl 4-pyrazolecarboxylate
- Purity
- 99%
- Packaging
- 500mg
- Price
- $24
- Updated
- 2023/01/07
TCI Chemical
- Product number
- E0871
- Product name
- Ethyl 4-Pyrazolecarboxylate
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $41
- Updated
- 2025/07/31
TCI Chemical
- Product number
- E0871
- Product name
- Ethyl 4-Pyrazolecarboxylate
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $117
- Updated
- 2025/07/31
TRC
- Product number
- P842560
- Product name
- 4-PyrazolecarboxylicAcidEthylEster
- Packaging
- 2.5g
- Price
- $155
- Updated
- 2021/12/16
Apolloscientific
- Product number
- OR13194
- Product name
- Ethyl1H-pyrazole-4-carboxylate
- Purity
- 98+%
- Packaging
- 5g
- Price
- $22
- Updated
- 2021/12/16
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Ethyl pyrazole-4-carboxylate Chemical Properties,Usage,Production
Chemical Properties
White to pale yellow crystalline powder
Uses
Used for the synthesis of isoxazole-4-carboxylic acid derivatives and isoxazole-3,5-dicarboxamides as herbicides.
Uses
Ethyl pyrazole-4-carboxylate is used for the synthesis of isoxazole-4-carboxylic acid derivatives and isoxazole-3,5-dicarboxamides.
Synthesis Reference(s)
Journal of Heterocyclic Chemistry, 30, p. 865, 1993 DOI: 10.1002/jhet.5570300404
Synthesis
80370-42-9
37622-90-5
The general procedure for the synthesis of ethyl 4-pyrazolecarboxylate from ethyl 2-formyl-3-oxopropanoate was as follows: 6.2 g (193 mmol) of hydrazine was slowly added to a solution of 27.6 g (192 mmol) of (ethoxycarbonyl)malondialdehyde dissolved in 150 mL of ethanol under ice bath cooling conditions. The reaction mixture was stirred at room temperature for 17 hours to complete the reaction. Subsequently, ethanol was removed from the reaction mixture by vacuum distillation. The residue was purified by silica gel column chromatography using a solvent mixture of dichloromethane and ethyl acetate as the unfolding agent, resulting in 19.4 g (72.4% yield) of ethyl 1H-pyrazole-4-carboxylate as yellow crystals.1H-NMR [CDCl3/TMS, δ (ppm)]: 8.08 (2H, s), 5.30 (1H, s), 4.31 ( 2H, q), 1.36 (3H, t).
References
[1] Tetrahedron, 2008, vol. 64, # 33, p. 7745 - 7758
[2] Journal of Heterocyclic Chemistry, 1993, vol. 30, # 4, p. 865 - 872
[3] Patent: EP1364946, 2003, A1. Location in patent: Page/Page column 196
[4] Patent: US2005/256004, 2005, A1. Location in patent: Page/Page column 32
Ethyl pyrazole-4-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Ethyl pyrazole-4-carboxylate manufacturers
Zibo Shiji Zhonglian Medical Technology Co., Ltd.
- Product
- Ethyl pyrazole-4-carboxylate 37622-90-5
- Price
- US $1.00/KG
- Min. Order
- 25KG
- Purity
- 99.0%
- Supply Ability
- 3000KG/th
- Release date
- 2023-06-16
Hebei Zhanyao Biotechnology Co. Ltd
- Product
- Ethyl 4-pyrazolecarboxylate 37622-90-5
- Price
- US $10.00/Kg/Bag
- Min. Order
- 1Kg/Bag
- Purity
- 99%
- Supply Ability
- 20 Tons
- Release date
- 2021-10-19
Zhuozhou Wenxi import and Export Co., Ltd
- Product
- Ethyl pyrazole-4-carboxylate 37622-90-5
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11
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