Tetracosactide acetate

Product Name: Tetracosactide acetate
CAS No.: 16960-16-0
Chemical Name: Tetracosactide acetate
Synonyms: TETRACOSACTIDE;synacthen;cortrosyn;tetracosactrin;Tetracosactide CRS;Tetracosactide acetate;SER-TYR-SER-MET-GLU-HIS-PHE-ARG-TRP-GLY-LYS-PRO-VAL-GLY-LYS-LYS-ARG-ARG-PRO-VAL-LYS-VAL-TYR-PRO;acth-z;C06926;ba30920
CBNumber: CB1325409
Molecular Formula: C136H210N40O31S
Formula Weight: 2933.44
MOL File: 16960-16-0.mol

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Tetracosactide acetate Property

Density: 1.47±0.1 g/cm3(Predicted)
storage temp.: −20°C
solubility: Sparingly soluble in water.
form: Solid
color: White to off-white
Water Solubility: Soluble in water
Sequence: H-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro-OH
Stability:: Hygroscopic
InChI: InChI=1S/C136H210N40O31S/c1-75(2)109(127(200)154-71-106(181)156-88(31-13-17-52-137)114(187)158-89(32-14-18-53-138)115(188)159-91(35-21-56-149-134(142)143)116(189)164-96(37-23-58-151-136(146)147)131(204)175-60-25-39-104(175)126(199)173-111(77(5)6)128(201)163-90(33-15-19-54-139)120(193)171-110(76(3)4)129(202)169-101(65-80-43-47-84(180)48-44-80)132(205)176-61-26-40-105(176)133(206)207)172-125(198)103-38-24-59-174(103)130(203)95(34-16-20-55-140)157-107(182)70-153-113(186)99(66-81-68-152-87-30-12-11-29-85(81)87)167-117(190)92(36-22-57-150-135(144)145)160-121(194)98(63-78-27-9-8-10-28-78)166-123(196)100(67-82-69-148-74-155-82)168-118(191)93(49-50-108(183)184)161-119(192)94(51-62-208-7)162-124(197)102(73-178)170-122(195)97(165-112(185)86(141)72-177)64-79-41-45-83(179)46-42-79/h8-12,27-30,41-48,68-69,74-77,86,88-105,109-111,152,177-180H,13-26,31-40,49-67,70-73,137-141H2,1-7H3,(H,148,155)(H,153,186)(H,154,200)(H,156,181)(H,157,182)(H,158,187)(H,159,188)(H,160,194)(H,161,192)(H,162,197)(H,163,201)(H,164,189)(H,165,185)(H,166,196)(H,167,190)(H,168,191)(H,169,202)(H,170,195)(H,171,193)(H,172,198)(H,173,199)(H,183,184)(H,206,207)(H4,142,143,149)(H4,144,145,150)(H4,146,147,151)/t86-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,109-,110-,111-/m0/s1
InChIKey: ZOEFCCMDUURGSE-SQKVDDBVSA-N
SMILES: C(N[C@@H](CC1C=CC(O)=CC=1)C(N[C@@H](CO)C(N[C@@H](CCSC)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC1N=CNC=1)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC1C2C(=CC=CC=2)NC=1)C(NCC(N[C@@H](CCCCN)C(N1CCC[C@H]1C(N[C@@H](C(C)C)C(NCC(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N1CCC[C@H]1C(N[C@@H](C(C)C)C(N[C@@H](CCCCN)C(N[C@@H](C(C)C)C(N[C@@H](CC1C=CC(O)=CC=1)C(N1CCC[C@H]1C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)([C@H](CO)N)=O
CAS DataBase Reference: 16960-16-0(CAS DataBase Reference)

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Safety

WGK Germany: 3
RTECS: GM7915000
HS Code: 2937220000
Hazardous Substances Data: 16960-16-0(Hazardous Substances Data)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H317May cause an allergic skin reaction

H332Harmful if inhaled

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P285In case of inadequate ventilation wear respiratory protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P304+P341IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P342+P311IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: A0298
Product name: Adrenocorticotropic Hormone Fragment 1-24 human, rat
Purity: ≥97% (HPLC)
Packaging: 250μg
Price: $101
Updated: 2024/03/01

Sigma-Aldrich

Product number: A0298
Product name: Adrenocorticotropic Hormone Fragment 1-24 human, rat
Purity: ≥97% (HPLC)
Packaging: 1mg
Price: $292
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1150115
Product name: Cosyntropin acetate
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 1.72MG
Price: $612
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1150115
Product name: Adrenocorticotropic Hormone Fragment 1-24 human, rat
Packaging: 1.69mg
Price: $574
Updated: 2022/05/15

Alfa Aesar

Product number: J66365
Product name: Adrenocorticotropic Hormone (1-24), human
Packaging: 1mg
Price: $153
Updated: 2023/06/20

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Tetracosactide acetate Chemical Properties,Usage,Production

Description

Cosyntropin (Tetracosactide acetate) is a synthetic polypeptide that consists of amino acid residues 1 through 24 of human ACTH, but that has the full biological activity of its parent. Because it is of synthetic origin, it is less allergenic than ACTH of natural origin. Cosyntropin is used as a diagnostic agent in the screening of patients suspected of having adrenocortical insufficiency. Normally, parenteral administration of cosyntropin acts rapidly on the adrenal cortex to effect release of plasma hydrocortisone; when performing the test, the hydrocortisone levels are compared to a control blood sample taken earlier.

Chemical Properties

White or yellow, amorphous powder.

Uses

Adrenocorticotropic Hormone (1-24), human is used in the treatment of West syndrome. It activates G proteins. It stimulates secretion of glucocorticoid steroid hormones from adrenal cortex cells. It also enhances transcription of mitochondrial genes.

Uses

Adrenocorticotropic Hormone Fragment 1-24 human, rat, has been used in corticosterone enzyme immunoassay and to induce color change in frogs.

Indications

Cosyntropin (Cortrosyn) is a polypeptide that consists solely of the first 24 amino acids of corticotropin. It appears to offer an advantage over the naturally occurring hormone in that it has a longer duration of action and lacks the antigenic portion of corticotropin. Although the short cosyntropin test is recognized as a valid screening test to assess adrenocortical insufficiency, the overnight metyrapone test or insulin hypoglycemia test may prove more sensitive.

Definition

ChEBI: A synthetic peptide that is identical to the 24-amino acid segment at the N-terminal of adrenocorticotropic hormone (corticotropin). A segment similar in all species, it contains the biological activity that stimulates production of cort costeroids in the adrenal cortex. It is used diagnostically to investigate adrenocortical insufficiency.

brand name

Cortrosyn (Amphastar).

General Description

Cosyntropin (Cortrosyn) is a syntheticpeptide containing the first 24 amino acids of natural corticotropin.Cosyntropin is used as a diagnostic agent to testfor adrenal cortical deficiency. Plasma hydrocortisone concentrationis determined before and 30 minutes after theadministration of 250 g of cosyntropin. Most normal responses result in an approximate doubling of the basalhydrocortisone concentration in 30 to 60 minutes. If the responseis not normal, adrenal insufficiency is indicated.Such adrenal insufficiency could be a result of either adrenalor pituitary malfunction, and further testing is requiredto distinguish between the two. Cosyntropin (250 μg infusedwithin 4–8 hours) or corticotropin (80–120 U/day for3–4 days) is administered. Patients with functional adrenaltissue should respond to this dosage. Patients who respondaccordingly are suspected of hypopituitarism, and the diagnosiscan be confirmed by other tests for pituitary function.Patients who have Addison disease, however, show little orno response.

Biological Activity

Tetracosactide Acetate (SR-TA) stimulates the release of corticosteroids such as cortisol from the adrenal gland. It is absorbed into a zinc phosphate complex, which ensures the sustained release of the active substance from the intramuscular injection site. SR-TA is currently used to manage ulcerative colitis, Crohn's disease, juvenile/adult rheumatoid arthritis, and osteoarthrosis[1].

Biochem/physiol Actions

Activates G proteins.

Side effects

Common side effects of Tetracosactide acetate may include: an allergic reaction (hives; difficult breathing; swelling of your face, lips, tongue, or throat); fast or slow heartbeats; increased blood pressure; rash; swelling in your hands or feet.

Veterinary Drugs and Treatments

Cosyntropin is used primarily as an alternative to ACTH to test for adrenocortical insufficiency (Addison’s), or hyperadrenocorticism, particularly in animals who have reacted immunologically to corticotropin in the past or if ACTH gel is unavailable.

References

[1] F. Iuliano, M. Rossi, Eleonora Iuliano. “Adding Slow Release Tetracosactide Acetate to Eltrombopag Improves Haematological Response in ITP Patients with Platelet-Count Fluctuation.” Blood (2018).

Tetracosactide acetate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Tetracosactide acetate manufacturers

HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD

Product: Tetracosactide acetate 16960-16-0
Price: US $500.00-300.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000
Release date: 2024-08-23

hebei hongtan Biotechnology Co., Ltd

Product: Cosyntropin 16960-16-0
Price: US $30.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 2000kg
Release date: 2024-03-20

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Tetracosactide Acetate 16960-16-0
Price: US $0.00/g
Min. Order: 1g
Purity: 98%min
Supply Ability: 1000g
Release date: 2023-01-12

16960-16-0, Tetracosactide acetateRelated Search:

Corticotropin Cortisone acetate BPP 9A Tolvaptan LHRH Ipamorelin Deslorelin Abarelix Teduglutide Semaglutide Teriparatide acetate Terlipressin acetate Teriparatideacetate Adrenocorticotropic hormone MET-GLU-HIS-PHE-ARG-TRP-GLY H-SER-TYR-SER-MET-GLU-HIS-PHE-ARG-TRP-GLY-LYS-PRO-VAL-NH2 PHE-PRO AC-LYS-PRO-VAL-NH2

L-SER-TYR-SER-MET-GLU-HIS-PHE-ARG-TRP-GLY-LYS-PRO-VAL-GLY-LYS-LYS-ARG-ARG-PRO-VAL-LYS-VAL-TYR-PRO

cosyntropin

H-SER-TYR-SER-MET-GLU-HIS-PHE-ARG-TRP-GLY-LYS-PRO-VAL-GLY-LYS-LYS-ARG-ARG PRO-VAL-LYS-VAL-TYR-PRO-OH TETRACOSACTIDE (HUMAN, BOVINE, MOUSE, OVINE, PORCINE, RABBIT, RAT)

H-SER-TYR-SER-MET-GLU-HIS-PHE-ARG-TRP-GLY-LYS-PRO-VAL-GLY-LYS-LYS-ARG-ARG-PRO-VAL-LYS-VAL-TYR-PRO-OH

SER-TYR-SER-MET-GLU-HIS-PHE-ARG-TRP-GLY-LYS-PRO-VAL-GLY-LYS-LYS-ARG-ARG-PRO-VAL-LYS-VAL-TYR-PRO HUMAN

SER-TYR-SER-MET-GLU-HIS-PHE-ARG-TRP-GLY-LYS-PRO-VAL-GLY-LYS-LYS-ARG-ARG-PRO-VAL-LYS-VAL-TYR-PRO

TETRACOSACTIDE

TETRACOSACTIDE (HUMAN)

SYSMEHFRWGKPVGKKRRPVKVYP

acth-alpha(1-24)

acthalpha(1-24)

actholain

acth-z

adrenocorticotropichormone1-24

adrenocorticotropin(1-24)

alpha(1-24)acth

alpha(1-24)-acth

alpha(1-24)-corticotropin

alpha(sup1-24)-corticotropin

ba30920

ba36716

beta(1-24)acth

beta(1-24)-acth

beta(1-24)-corticotropin

beta(1-24)-tetracosactide

beta(sup1-24)-corticotropin

beta-corticotrophin-(1-24)-tetracosapeptide

corticotropin-(1-24)

cortrophins

cortrosinta

cortrosyn

enylalanyl-l-arginyl-l-tryptophylglycyl-l-l///

l-proline,l-seryl-l-tyrosyl-l-seryl-l-methionyl-l-glutamyl-l-alpha-histidyl-ph

Tetracosactide, Cosyntropin, Tetracosactrin

Adrenocorticotropic hormone fragment 1-24 human (ACTH)

nuvacthendepot

porcineacth(1-24)

synacthen

synecthen

tetracosactid

tetracosactrin

tetracosapeptide

Fam-ACTH (1-24), human

α1-24-Adrenocorticotropic-d4 Hormone

α1-24-Adrenocorticotropic Hormone

Cosyntropin Acetate

1-icosyl-8-methyl-8-azabicyclo[3.2.1]octan-3-ol

Tetracosactide(1-24)/ACTH (1-24) Acetate

Tetracosactide, Tetracosactida, Tetracosactidum

Adrenocorticotropic Hormone (ACTH) (1-24), human

Tetracosactide Acetae

Adrenocorticotropic hormone fragment 1-24 human (ACTH), ≥97% (HPLC)

ACTH(1-24)/Cosyntropin

Tetrocosactide(ACTH)

ADRENOCORTICOTROPIC HORMONE FRAGMENT1-24 HUMAN

adrenocorticotropic hormone fragment 1-24 human, rat

Tetracosactide acetate

ACTH (1-24), HUMAN