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2-Chloro-5-acetylpyridine

Application
Product Name
2-Chloro-5-acetylpyridine
CAS No.
55676-22-7
Chemical Name
2-Chloro-5-acetylpyridine
Synonyms
1-(6-CHLOROPYRIDIN-3-YL)ETHANONE;1-(6-Chloropyridin-3-yl)ethan-1-one;1-(6-CHLORO-3-PYRIDINYL)-1-ETHANONE;3-Acetyl-6-chloropyridine;5-Acetyl-2-chloropyridine;6-CHLORO-3-ACETYLPYRIDINE;2-CHLORO-5-ACETYLPYRIDINE;5-Acetyl-2-chloropyridine >1-(6-Chlorpyridin-3-yl)ethanon;1-(6-chloro-3-pyridinyl)ethanone
CBNumber
CB1354254
Molecular Formula
C7H6ClNO
Formula Weight
155.58
MOL File
55676-22-7.mol
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2-Chloro-5-acetylpyridine Property

Melting point:
98 °C
Boiling point:
280.5±20.0 °C(Predicted)
Density 
1.233±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
form 
powder to crystal
pka
-2.14±0.10(Predicted)
color 
White to Light yellow to Light orange
InChI
InChI=1S/C7H6ClNO/c1-5(10)6-2-3-7(8)9-4-6/h2-4H,1H3
InChIKey
UXSNZYGTQTXRAD-UHFFFAOYSA-N
SMILES
C(=O)(C1=CC=C(Cl)N=C1)C
CAS DataBase Reference
55676-22-7
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Safety

Hazard Codes 
Xn
Risk Statements 
22-36
Safety Statements 
26
Hazard Note 
Harmful
HazardClass 
IRRITANT
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical
Product number
A2796
Product name
5-Acetyl-2-chloropyridine
Purity
>98.0%(GC)
Packaging
1g
Price
$40
Updated
2025/07/31
TCI Chemical
Product number
A2796
Product name
5-Acetyl-2-chloropyridine
Purity
>98.0%(GC)
Packaging
5g
Price
$122
Updated
2025/07/31
TRC
Product number
C596183
Product name
1-(6-Chloropyridin-3-yl)ethanone
Packaging
100mg
Price
$60
Updated
2021/12/16
TRC
Product number
C596183
Product name
1-(6-Chloropyridin-3-yl)ethanone
Packaging
50mg
Price
$45
Updated
2021/12/16
Matrix Scientific
Product number
046735
Product name
1-(6-Chloro-3-pyridinyl)-1-ethanone
Purity
95+%
Packaging
1g
Price
$18
Updated
2021/12/16
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2-Chloro-5-acetylpyridine Chemical Properties,Usage,Production

Application

2-Chloro-5-acetylpyridine is also used industrially as a denaturant and dyeing aid.

Synthesis

923034-23-5

55676-22-7

Step 3 Synthesis of 1-(6-chloropyridin-3-yl)ethanone: Dimethyl 2-(6-chloronicotinoyl)malonate (89.8 g, 331 mmol) was dissolved in a solvent mixture of DMSO (445 mL) and water (11 mL), and the reaction was heated for 2.5 hr at 130 °C. After the reaction was completed, the reaction mixture was cooled and poured into H2O/ice (300 mL). The aqueous phase was extracted with EtOAc (4 x 150 mL). The organic phases were combined, washed with brine, dried and concentrated under reduced pressure. The residue was recrystallized by 60% ethanol-water solution to afford the target compound 1-(6-chloropyridin-3-yl)ethanone in a yield of 16.5 g (32% yield) as a yellow solid.

References

[1] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 23, p. 6093 - 6096
[2] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 24, p. 6482 - 6485
[3] Patent: US2007/27184, 2007, A1. Location in patent: Page/Page column 17; 19
[4] Tetrahedron, 1992, vol. 48, # 42, p. 9233 - 9236
[5] Bioorganic and Medicinal Chemistry Letters, 2003, vol. 13, # 18, p. 3041 - 3044

2-Chloro-5-acetylpyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Chloro-5-acetylpyridine Suppliers

Americas 1 Belgium 2 China 236 Europe 1 France 1 Germany 4 India 14 Japan 1 South Korea 1 Switzerland 1 United Kingdom 7 United States 26 Global 295
U Chem Co., Ltd.
Tel
--
Fax
--
Email
sales@u-chem.co.kr
Country
South Korea
ProdList
88
Advantage
58
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View Lastest Price from 2-Chloro-5-acetylpyridine manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
2-Chloro-5-acetylpyridine 55676-22-7
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2022-09-29
Nanjing Fred Technology Co., Ltd
Product
2-Chloro-5-acetylpyridine 55676-22-7
Price
US $0.00-0.00/kg
Min. Order
0.1kg
Purity
99%
Supply Ability
5 ton
Release date
2023-11-29
LY Global chemicals co.,ltd .
Product
2-Chloro-5-acetylpyridine 55676-22-7
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1000kg
Release date
2023-03-27

55676-22-7, 2-Chloro-5-acetylpyridineRelated Search:

Acetyl coenzyme A sodium salt Acetyl chloride 4-Acetylpyridine N-ACETYL-L-TYROSINE ETHYL ESTER 2-Chloro-3-cyanopyridine Clopidol 2-Chloro-5-nitropyridine 2-Acetylpyridine 3-Acetylpyridine 2-Chloro-5-methylpyridine Acetylacetone L-PICEIN 2-Chloro-5-chloromethylpyridine Ethanone, 1-(4-amino-3-hydroxyphenyl)- (9CI) 2-Amino-5-Acetylpyridine Ethanone, 1-(6-quinoxalinyl)- (9CI) Ethanone, 1-(6-amino-3-pyridinyl)- pyridinium Chlorochromate

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  • 1-(6-CHLOROPYRIDIN-3-YL)ETHANONE
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  • Ethanone, 1-(6-chloro-3-pyridinyl)-
  • 1-(6-CHLORO-3-PYRIDINYL)-1-ETHANON
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  • 2-CHLORO-5-ACETYLPYRIDINE
  • 5-Acetyl-2-chloropyridine &gt
  • 2-Chloro-5-acetylpyridine ISO 9001：2015 REACH
  • 1-(6-Chlorpyridin-3-yl)ethanon
  • 55676-22-7
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  • Heterocycle-Pyridine series