ChemicalBook > CAS DataBase List > 2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid

2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid

Product Name
2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid
CAS No.
4065-45-6
Chemical Name
2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid
Synonyms
BENZOPHENONE-4;BP-4;SULISOBENZONE;uvinul;UV-284;HMBS;5-BENZOYL-4-HYDROXY-2-METHOXYBENZENESULFONIC ACID;BIP1;2-HYDROXY-4-METHOXYBENZOPHENONE-5-SULPHONIC ACID;ms40
CBNumber
CB1359279
Molecular Formula
C14H12O6S
Formula Weight
308.31
MOL File
4065-45-6.mol
More
Less

2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid Property

Melting point:
170 °C
Boiling point:
0°C
Density 
1.4574 (rough estimate)
vapor pressure 
0Pa at 25℃
refractive index 
1.5300 (estimate)
Flash point:
0°C
storage temp. 
Inert atmosphere,Room Temperature
solubility 
DMSO (Slightly), Methanol (Slightly)
pka
-0.70±0.50(Predicted)
form 
Solid
color 
White to Off-White
Water Solubility 
300.92g/L at 25℃
Merck 
14,8983
BRN 
2889165
InChIKey
CXVGEDCSTKKODG-UHFFFAOYSA-N
LogP
0.515 at 25℃
CAS DataBase Reference
4065-45-6(CAS DataBase Reference)
EPA Substance Registry System
Sulisobenzone (4065-45-6)
More
Less

Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-37/39-36/37/39-27
WGK Germany 
1
RTECS 
DB5044300
TSCA 
Yes
HS Code 
29147000
Hazardous Substances Data
4065-45-6(Hazardous Substances Data)
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
1642100
Product name
Sulisobenzone
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
500mg
Price
$483
Updated
2024/03/01
Sigma-Aldrich
Product number
09649
Product name
5-Benzoyl-4-hydroxy-2-methoxybenzenesulfonic acid
Purity
≥97.0% (HPLC)
Packaging
10g
Price
$114
Updated
2024/03/01
TCI Chemical
Product number
H0466
Product name
2-Hydroxy-4-methoxybenzophenone-5-sulfonic Acid Hydrate(contains 5-10% Isopropyl Alcohol)
Purity
>98.0%(T)
Packaging
25g
Price
$49
Updated
2024/03/01
TCI Chemical
Product number
H0466
Product name
2-Hydroxy-4-methoxybenzophenone-5-sulfonic Acid Hydrate(contains 5-10% Isopropyl Alcohol)
Purity
>98.0%(T)
Packaging
500g
Price
$334
Updated
2024/03/01
Alfa Aesar
Product number
L12912
Product name
2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid hydrate, tech. 85%, may cont. up to 10% 2-propanol
Packaging
10g
Price
$66.65
Updated
2024/03/01
More
Less

2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid Chemical Properties,Usage,Production

Description

UV light absorber 2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid (INCI title Benzophenone-4; Hereinafter to be referred to as BP-4) can absorb UV-A and UV-B simultaneously; Be a kind of wide spectrum, water-soluble UV light absorber; To advantages such as light, Heat stability is goods, be used for water-soluble makeup and make sun-screening agent. Being the cosmetics additive that Europe and Japanese rules allow use, it is also the first kind of sun-screening agent of drugs approved by the FDA and is simultaneously the UV light absorber that China's cosmetics health standard (2002 editions) permission. Its acute toxicity: the oral medium lethal dose LD50=3530mg/kg of mouse belongs to the low toxicity chemical.

Chemical Properties

white to yellowish powder

Originator

Uval,Dome,US,1965

Uses

Ultraviolet absorber for leather and textile fibers; in cosmetics and shampoos.

Uses

2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid is a commonly used, FDA approved sunscreen chemical with uVA-absorbing properties and an approved usage level of 5 to 10 percent. It protects a formulation from the effects of uV-light exposure. Sulisobenzone is the drug name for benzophenone-4, a sunscreen chemical.

Definition

ChEBI: Sulisobenzone is a member of benzophenones.

Manufacturing Process

663 g of dichloroethane and 74.6 g 2-hydroxy-4-methoxybenzophenone were charged into a 3-neck flask equipped with stirrer, thermometer, reflux condenser and dropping funnel and a heating mantle. The solution was heated to the reflux temperature (85°C to 86°C) and was dehydrated by distilling off 66.5 g 1,2-dichloroethane. While maintaining at reflux, 30 g chlorosulfonic acid was added slowly over a period of about two hours. The rate of addition was regulated by the speed of evolution of the HCl. After all the chlorosulfonic acid was added, the charge was still maintained at reflux for an additional 15 minutes to remove traces of HCl. It was then cooled to 5°C and filtered. The filter cake was washed with 500 g cold 1,2-dichloroethane and dried. 98 g of product were obtained.

brand name

Sungard (Bayer).

Therapeutic Function

Sunscreen agent

General Description

Sulisobenzone is a broad spectrum organic UV filter in sunscreen formulations, known to absorb deleterious UV light.

Flammability and Explosibility

Non flammable

Contact allergens

BZP-4 is widely used in cosmetics, particularly shampoos and hair products. Cross-reactivity is rarely expected in patients photoallergic to ketoprofen.

Synthesis

Adding 2-hydroxy-4-methoxybenzophenone and a solvent into an enamel reaction kettle, dripping chlorosulfonic acid under the protection of nitrogen with stirring, controlling the temperature of materials in the kettle to be 20 to 25 DEG C through jacket water bath cooling by controlling the dripping speed of the chlorosulfonic acid, and reacting for 20 to 25 hours; performing centrifugal filtering separation on a product after the reaction is finished, washing the product by using the corresponding solvent, and drying the product under the protection of the nitrogen; and recycling a hydrogen chloride (HCl) byproduct in an HCl recycling packed tower in a water circulation mode to form a 20 to 30 % hydrochloric acid aqueous solution, and recycling the 2-hydroxy-4-methoxybenzophenone and the 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid from raffinate at the bottom of the kettle.

Regulations

2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid is a cosmetic material; the allowance state of countries in the world (maximum usage quantity wt%) is as follows: Europe: 5.0%; Australia: 10%; Japan: 10.0%; The U.S.: 10.0%; China: 5%.

2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid Preparation Products And Raw materials

Raw materials

1,3-Dimethoxybenzene Resorcinol

Preparation Products

More
Less

2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid Suppliers

Americas 1 Belgium 1 China 431 Europe 5 Germany 8 India 22 Japan 2 Slovakia 1 South Korea 2 Switzerland 1 Ukraine 1 United Kingdom 13 United States 55 Global 543
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
HBCChem, Inc.
Tel
+1-510-219-6317
Fax
+1-650-486-1361
Email
sales@hbcchem.com
Country
United States
ProdList
10648
Advantage
60
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4660
Advantage
60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32161
Advantage
58
Alfa Chemistry
Tel
Fax
1-516-927-0118
Email
Info@alfa-chemistry.com
Country
United States
ProdList
24072
Advantage
58
Protheragen-ING
Tel
+16313385890
Email
info@protheragen-ing.com
Country
United States
ProdList
3868
Advantage
58
TargetMol Chemicals Inc.
Tel
+8613564774135
Email
zijue.cai@tsbiochem.com
Country
United States
ProdList
19881
Advantage
58
TargetMol Chemicals Inc.
Tel
Email
support@targetmol.com
Country
United States
ProdList
38631
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
United States Biological
Tel
--
Fax
--
Email
chemicals@usbio.net
Country
United States
ProdList
6214
Advantage
80
Penta International Corporation
Tel
--
Fax
--
Email
lisaa@pentamfg.com
Country
United States
ProdList
5042
Advantage
58
OQEMA
Tel
--
Fax
--
Email
fandf@oqema.co.uk
Country
United States
ProdList
578
Advantage
58
Glentham Life Sciences Ltd
Tel
--
Fax
--
Email
info@glentham.com
Country
United States
ProdList
2026
Advantage
58
TCI America
Tel
--
Fax
--
Email
sales@tciamerica.com
Country
United States
ProdList
6909
Advantage
75
MedChemExpress
Tel
--
Fax
--
Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58
Combi-Blocks Inc.
Tel
--
Fax
--
Email
sales@combi-blocks.com
Country
United States
ProdList
6618
Advantage
69
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87
Frontier Scientific, Inc.
Tel
--
Fax
--
Email
sales@frontiersci.com
Country
United States
ProdList
6222
Advantage
86
Matrix Scientific
Tel
--
Fax
--
Email
sales@matrixscientific.com
Country
United States
ProdList
6632
Advantage
80
CarboMer, Inc.
Tel
--
Fax
--
Email
sales@carbomer.com
Country
United States
ProdList
4026
Advantage
67
HBCChem Inc.
Tel
--
Fax
--
Email
sales@hbcchem-inc.com
Country
United States
ProdList
4569
Advantage
30
Ivy Fine Chemicals
Tel
--
Fax
--
Email
sales@ivychem.com
Country
United States
ProdList
6493
Advantage
58
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6962
Advantage
56
Waterstone Technology, LLC
Tel
--
Fax
--
Email
sales@waterstonetech.com
Country
United States
ProdList
6786
Advantage
30
AlliChem, LLC
Tel
--
Fax
--
Email
sales@allichemllc.com
Country
United States
ProdList
6516
Advantage
60
ChemService Inc.
Tel
--
Fax
--
Country
United States
ProdList
6379
Advantage
68
Penta Manufacturing Company
Tel
--
Fax
--
Email
sales@pentamfg.com
Country
United States
ProdList
5076
Advantage
65
NetQem
Tel
--
Fax
--
Email
sales@netqem.us
Country
United States
ProdList
1641
Advantage
38
Protaeen Chemicals Inc.
Tel
--
Fax
--
Email
AMANDA@PROTAMEEN.COM
Country
United States
ProdList
4
Advantage
47
2A PharmaChem USA
Tel
--
Fax
--
Email
sales@2apharmachem.com
Country
United States
ProdList
6137
Advantage
39
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6718
Advantage
47
HONEST JOY HOLDINGS LIMITED
Tel
--
Fax
--
Email
sales@honestjoy.cn
Country
United States
ProdList
6675
Advantage
54
Acros Organics USA
Tel
--
Fax
--
Email
eveleth@fisherchem.com
Country
United States
ProdList
3846
Advantage
81
C-Tech Corporation
Tel
--
Fax
--
Country
United States
ProdList
17
Advantage
55
Fine Chem Trading LTD
Tel
--
Fax
--
Email
chemfinder@chemfinder.co.uk
Country
United States
ProdList
1609
Advantage
64
Sciencelab.com, Inc.
Tel
--
Fax
--
Email
accounting@sciencelab.com
Country
United States
ProdList
4159
Advantage
82
APAC Pharmaceutical, LLC
Tel
--
Fax
--
Email
sales@apacpharma.com
Country
United States
ProdList
6322
Advantage
38
Aagile Labs Division of Tyger Scientific
Tel
--
Fax
--
Email
tygersci@yahoo.com
Country
United States
ProdList
6568
Advantage
68
Advance Scientific & Chemical
Tel
--
Fax
--
Email
sales@advance-scientific.com
Country
United States
ProdList
6419
Advantage
71
Vinayak Corporation
Tel
--
Fax
--
Country
United States
ProdList
5
Advantage
70
MP Biomedicals, Inc.
Tel
--
Fax
--
Country
United States
ProdList
6561
Advantage
81
AK Scientific, Inc.
Tel
--
Fax
--
Email
sales@aksci.com
Country
United States
ProdList
6347
Advantage
65
Pechiney
Tel
--
Fax
--
Email
chemicals@pechiney.com
Country
United States
ProdList
606
Advantage
55
ASDI Incorporated
Tel
--
Fax
--
Email
customerservice@asdi.net
Country
United States
ProdList
6922
Advantage
67
Beta Pharma, Inc.
Tel
--
Fax
--
Email
sales@betapharma.com
Country
United States
ProdList
6226
Advantage
60
Norquay Technology Incorporated, U.S.A.
Tel
--
Fax
--
Email
sales@norquaytech.com
Country
United States
ProdList
116
Advantage
51
ChemPacific Corporation
Tel
--
Fax
--
Email
sales@chempacific.com
Country
United States
ProdList
6891
Advantage
51
Alfa Aesar
Tel
--
Fax
--
Email
tech@alfa.com
Country
United States
ProdList
6814
Advantage
81
TimTec Corporation
Tel
--
Fax
--
Email
info@timtec.net
Country
United States
ProdList
6891
Advantage
68
More
Less

View Lastest Price from 2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
UV-284 Benzophenone-4 4065-45-6
Price
US $120.00-65.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-04-26
WUHAN FORTUNA CHEMICAL CO., LTD
Product
2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid 4065-45-6
Price
US $0.00-0.00/Kg/Drum
Min. Order
1KG
Purity
99%min
Supply Ability
1000kg
Release date
2021-11-04
Wuhan Fortuna Chemical Co.,Ltd
Product
2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid 4065-45-6
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10tons
Release date
2024-08-23

4065-45-6, 2-Hydroxy-4-methoxybenzophenone-5-sulfonic acidRelated Search:

Benzoyl chloride (Trifluoromethoxy)benzene Octabenzone Oxybenzone CHLOROPHOSPHONAZO III UV-329 Drometrizole Benzophenone Benzoyl peroxide 4-Hydroxybenzophenone Ethyl 4-[[(methylphenylamino)methylene]amino]benzoate UV Absorber 326 4-Methylbenzophenone 2-Phenylbenzimidazole-5-sulfonic acid 4-Methoxybenzophenone 3-Aminophenol Phenol Red Phenol

  • Uvistat 1121
  • UV ABSORBER HMBS
  • 5-BENZOYL-4-HYDROXY-2-METHOXYBENZENESULFONIC ACID
  • TIMTEC-BB SBB002961
  • SULISOBENZONE
  • spectra-sorb uv 284
  • 2-HYDROXY-4-METHOXYBENZOPHENONE-5-SULPHONIC ACID
  • Uv absorber BP-4(UV-284)
  • Uvasorb?S5,
  • 2-HYDROXY-4-METHOXYBENZOPHENONE-5-SULFONIC ACID
  • 2-HYDROXY-4-METHOXYBENZOPHENONE-5-SULFONIC ACID HYDRATE
  • 2-HYDROXY-4-METHOXY-5-SULFOBENZOPHENONE
  • 2-HYDROXY-4-METHOXY-5-SULFONYLBENZOPHENONE
  • 2-Benzoyl-5-methoxy-1-phenol-4-sulfonic acid
  • HMBS
  • BP-4
  • BENZOPHENONE-4
  • 2-benzoyl-5-methoxy-1-phenol-4-sulfonicaci
  • 2-Hydroxy-4-Methoxy-5-Benzophenonesulfonicacid
  • 5-benzoyl-4-hydroxy-2-methoxy-benzenesulfonicaci
  • 2-Hydoxy-4-methoxybenzophenone-5-sulfonic acid
  • Sulisobenzone (500 mg)
  • 5-Benzoyl-4-hydroxy-2-methoxybenzenesulfonic Acid Sulisobenzone
  • Benzenesulfonicacid,5-benzoyl-4-hydroxy-2-methoxy-
  • Benzophenone-4,sulisobenzone
  • ms40
  • Samsorb-4MS
  • seesorb101s
  • syntase230
  • uval
  • UvinualMS-40
  • uvinul
  • uvinulms40
  • UVSOB340
  • UV-284
  • 2-Hydroxy-4-Methoxy-5-Sulffonylbenzophenone(BP-4)
  • 2-Hydroxy-4-Methoxy-5-Sulfo-
  • UV absorber UV BP-4
  • Hydroxy-4-Methoxybenzophenone-5-sulfonic Acid
  • 5-Benzoyl-4-hydroxy-2-Methoxybenzenesulfonic acid >=97.0% (HPLC)
  • 2- hydroxy-4-Methoxy -5-sulfonic acid twoBenzophenone
  • 2 - hydroxy - 4 - Methoxy - 5 - sulphonic acid diphenyl ketone
  • 2 - hydroxy - 4 - Methoxy diphenyl ketone - 5 - sulphonic acid
  • 5-Benzoyl-4-hy
  • Anti-BIK, N-Terminal antibody produced in rabbit
  • Apoptosis inducer NBK
  • Bcl-2 interacting killer
  • BIKLK
  • BIP1
  • 2-hydroxy-4-methoxy-5-sulphoic benzophenone UV284 BP4
  • -4-hydroxy-2-methoxybenzenesuL
  • 5-BenzoyL
  • 2-Hydroxy-4-Methoxy-5-sulfonylbenzophenone (Benzophenone-4)
  • 5-Benzoyl-4-hydroxy-2-methoxybenzene sulfonic aid
  • 2-HYDROXY-4-METHOXY-5-SULFONYLBENZOPHENONE(BP-4)
  • 2-Hydroxy-4-Methoxy-5-SulphoicBenzophenoneUv284Bp4A2093
  • BENZOPHENONE-4 (UV 284)
  • BENZENESULPHONICACID,5-BENZOYL-4-HYDROXY-2-METHOXY-