ChemicalBook > CAS DataBase List > Buspirone

Buspirone

Product Name
Buspirone
CAS No.
36505-84-7
Chemical Name
Buspirone
Synonyms
BUSPIRONE HCL;buspar;8-[4-[4-(2-PYRIMIDINYL)-1-PIPERAZINYL]BUTYL]-8-AZASPIRO[4,5]DECANE-7,9-DIONE;Buspisal;Buspimen;BUSPIRONE;Nard：Tmvin;BUPROPIONHCL;BUSPIRONE,USP;Ansiced：Axoren
CBNumber
CB1367137
Molecular Formula
C21H31N5O2
Formula Weight
385.5
MOL File
36505-84-7.mol
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Buspirone Property

Melting point:
105-107 °C(Solv: ethyl acetate (141-78-6))
Boiling point:
511.93°C (rough estimate)
Density 
1.1527 (rough estimate)
refractive index 
1.7600 (estimate)
storage temp. 
Sealed in dry,2-8°C
pka
pKa 7.60±0.01(H2O t=25.0 I=0.1(NaCl)) (Uncertain)
BCS Class
1
CAS DataBase Reference
36505-84-7(CAS DataBase Reference)
NIST Chemistry Reference
8-Azaspiro[4.5]decane-7,9-dione, 8-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-(36505-84-7)
EPA Substance Registry System
8-Azaspiro[4.5]decane-7,9-dione, 8-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]- (36505-84-7)
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Safety

Hazard Codes 
T
Risk Statements 
25
Safety Statements 
45
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
RTECS 
CL9915000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
B689855
Product name
Buspirone
Packaging
100mg
Price
$65
Updated
2021/12/16
TRC
Product number
C371285
Product name
5-ChloroBuspirone
Packaging
10mg
Price
$255
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
INB0000487
Product name
BUSPIRONE
Purity
95.00%
Packaging
5MG
Price
$504.94
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
INB0000487
Product name
BUSPIRONE
Purity
95.00%
Packaging
1G
Price
$2344.65
Updated
2021/12/16
AHH
Product number
MT-46118
Product name
8-[4-[4-(2-Pyrimidinyl)-1-piperazinyl]butyl]-8-azaspiro[4,5]decane-7,9-dione
Purity
98%
Packaging
0.1g
Price
$680
Updated
2021/12/16
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Buspirone Chemical Properties,Usage,Production

Uses

Tranquilizer (minor).

Uses

Buspirone is an extremely specific drug that could possibly represent a new chemical class of anxiolytics—azaspirones. As an anxiolytic, its activity is equal to that of benzodiazepines; however, it is devoid of anticonvulsant and muscle relaxant properties, which are characteristic of benzodiazepines.

Uses

5-Chloro Buspirone is an impurity of Buspirone Hydrochloride (B689850), a non-benzodiazepine anxiolytic and a 5-hydroxytryptamine (5-HT1) receptor agonist.

Definition

ChEBI: An azaspiro compound that is 8-azaspiro[4.5]decane-7,9-dione substituted at the nitrogen atom by a 4-(piperazin-1-yl)butyl group which in turn is substituted by a pyrimidin-2-yl group at the N4 position.

brand name

Buspar (Bristol-Myers Squibb).

Biological Functions

Buspirone (BuSpar) is the first example of a class of anxiolytic agents that can relieve some symptoms of anxiety in doses that do not cause sedation. Buspirone is structurally unrelated to existing psychotropic drugs.

General Description

The initial compound in this series, buspirone (BuSpar), hasanxiolytic and antidepressant activities and is a partial5-HT1A agonist. Its anxiolytic activity is reportedly causedby its ability to diminish 5-HT release (via 5-HT1A agonism).High short-term synaptic levels of 5-HT are characteristic ofanxiety. Also, because it is a partial agonist, it can stimulatepostsynaptic receptors when 5-HT levels are low in thesynapse, as is the case in depression. Several other spironesare in development as anxiolytics and antidepressants.

Mechanism of action

Although buspirone has been shown to interact with a number of neurotransmitter systems in the brain, it appears that its clinically relevant effects are mediated through interactions at the serotonin (5-hydroxytryptamine, 5-HT) 5-HT1A receptor, where it acts as a partial agonist.

Pharmacology

Buspirone is as effective as the benzodiazepines in the treatment of general anxiety. However, the full anxiolytic effect of buspirone takes several weeks to develop, whereas the anxiolytic effect of the benzodiazepines is maximal after a few days of therapy. In therapeutic doses, buspirone has little or no sedative effect and lacks the muscle relaxant and anticonvulsant properties of the benzodiazepines. In addition, buspirone does not potentiate the central nervous system depression caused by sedative–hypnotic drugs or by alcohol, and it does not prevent the symptoms associated with benzodiazepine withdrawal.

Clinical Use

Buspirone is effective in general anxiety and in anxiety with depression.

Side effects

Like the benzodiazepines, buspirone appears to be safe even when given in very high doses. The most common side effects are dizziness, light-headedness, and headache. Abuse, dependence, and withdrawal have not been reported, and buspirone administration does not produce any cross-tolerance to the benzodiazepines. Buspirone has been reported to increase blood pressure in patients taking monoamine oxidase inhibitors, and it may increase plasma levels of haloperidol if coadministered with that agent.

Synthesis

Buspirone, 8-[4-[4-(2-pyrimidyl)-1-piperazinyl]butyl]-8-azaspiro [4,5] decan-7,9-dione (5.2.6), is synthesized by the reaction of 1-(2-pyrimidyl)-4- (4-aminobutyl)piperazine (5.2.4) with 8-oxaspiro[4,5]decan-7,9-dione (5.2.5). In turn, 1- (2-pyrimidyl)-4-(4-aminobutyl)piperazine (5.2.4) is synthesized by the reaction of 1-(2-pyrimidyl)piperazine with 4-chlorobutyronitrile, giving 4-(2-pyrimidyl)-1-(3- cyanopropyl)piperazine (5.2.3), which is hydrogenated with Raney nickel into buspirone (5.2.4) [51¨C55].

Metabolism

Buspirone is well absorbed from the gastrointestinal tract, and peak blood levels are achieved in 1 to 1.5 hours; the drug is more than 95% bound to plasma proteins. Buspirone is extensively metabolized, with less than 1% of the parent drug excreted into the urine unchanged. At least one of the metabolic products of buspirone is biologically active. The parent drug has an elimination half-life of 4 to 6 hours.

Buspirone Preparation Products And Raw materials

Raw materials

Concentrated hydrochloric acid 2-(1-Piperazinyl)pyrimidine Glutarimide Triethylamine 2-Aminopyrimidine Chloroform Piperazine Sodium nitrite 2-Chloropyrimidine Dichloromethane Glutaric anhydride 2-Cyanoacetamide Glutaric acid Cyclopentanone Isopropyl alcohol Methyl cyanoacetate

Preparation Products

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Buspirone Suppliers

China 80 Europe 2 Germany 1 India 4 Switzerland 2 United Kingdom 7 United States 16 Global 112
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View Lastest Price from Buspirone manufacturers

Hebei Mojin Biotechnology Co., Ltd
Product
Buspirone 36505-84-7
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2024-03-29
Dideu Industries Group Limited
Product
Buspirone 36505-84-7
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons min
Release date
2021-07-22
Career Henan Chemical Co
Product
Buspirone 36505-84-7
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
JD 580
Release date
2019-09-01

36505-84-7, BuspironeRelated Search:

Butyl acetate Decane Butyl acrylate Buprofezin tert-Butanol Piperazine 2-Butoxyethanol Piperacillin N-Aminoethylpiperazine 2-Ethylhexyl ferulate 1-Methylpiperazine Homopiperazine Buspirone Hydrochlorid,BUSPIRONE HCL,BUSPIRONE HYDROCHLORIDE Bromophenol Red 6-Hydroxy Buspirone-d8 BUSPIRONE (D8),BUSPIRONE-D8 HCL (BUTYL-D8),Buspirone-d8 Hydrochloride,Buspirone-d8 HCl 6-HYDROXY BUSPIRONE BUSPIRONE FOR SYSTEM SUITABILITY

  • 8-[4-[4-(2-PYRIMIDINYL)-1-PIPERAZINYL]BUTYL]-8-AZASPIRO[4,5]DECANE-7,9-DIONE
  • 8-[4-[4-(2-PYRIMIDINYL)-1-PIPERAZINYL]BUTYL]-8-AZASPIRO[4,5]DECANE-7,9-DIONE HYDROCHLORIDE
  • 5)decane-7,9-dione,8-(4-(4-(2-pyrimidinyl)piperizinyl)butyl)-8-azaspiro(
  • 8-(4-(4-(2-pyrimidinyl)-1-piperizinyl)butyl)-8-azaspiro(4,5)decane-7,9-dione
  • BUSPIRONE,USP
  • Buspirone (base and/or unspecified salts)
  • BUPROPIONHCL
  • Ansiced：Axoren
  • Buspimen
  • Buspisal
  • Nard：Tmvin
  • buspar
  • BUSPIRONE
  • BUSPIRONE HCL
  • Buspirone Impurity
  • 5-Chloro Buspirone
  • Buspirone EP Impurity D Hydrochloride
  • 8-[4-(4-pyrimidin-2-ylpiperazin-1-yl)butyl]-8-azaspiro[4.5]decane-7,9-dione
  • 8-[4-(4-pyrimidin-2-ylpiperazin-1-yl)butyl]-8-azaspiro[4.5]decane-7,9-quinone
  • 8-Azaspiro[4.5]decane-7,9-dione,8-[4-[4-(2-pyriMidinyl)-1-piperazinyl]butyl]-
  • Buspirone for system suitability CRS
  • Buspirone USP/EP/BP
  • 36505-84-7 Buspirone
  • Buspirone free base
  • 5-HT Receptor,inhibit,5-hydroxytryptamine Receptor,Serotonin Receptor,Reactive Oxygen Species,anxiety,Buspirone,Inhibitor,depression,5-HT1A receptor
  • Refametinib Impurity 5
  • 36505-84-7
  • C21H31N5O2