ChemicalBook > CAS DataBase List > Fmoc-L-tert-leucine

Fmoc-L-tert-leucine

Product Name
Fmoc-L-tert-leucine
CAS No.
132684-60-7
Chemical Name
Fmoc-L-tert-leucine
Synonyms
FMOC-TLE-OH;(S)-2-((((9H-Fluoren-9-yl)Methoxy)carbonyl)aMino)-3,3-diMethylbutanoic acid;FMOC-TBU-GLY-OH;FMOC-L-TLE-OH;FMOC-TBU-GLYCINE;FMOC-L-T-LEUCINE;RARECHEM EM WB 0083;FMOC-L-TERT-LEUCINE;FMOC-L-T-BUTYLGLYCINE;N-Fmoc-L-tert-leucine
CBNumber
CB1386464
Molecular Formula
C21H23NO4
Formula Weight
353.41
MOL File
132684-60-7.mol
More
Less

Fmoc-L-tert-leucine Property

Melting point:
124-127 °C
Boiling point:
554.1±33.0 °C(Predicted)
Density 
1.209±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
≥ 35.3mg/mL in DMSO, ≥ 49.6 mg/mL in EtOH
pka
3.92±0.10(Predicted)
form 
powder to crystal
color 
White to Light yellow
BRN 
6662856
CAS DataBase Reference
132684-60-7(CAS DataBase Reference)
More
Less

Safety

Safety Statements 
22-24/25
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29242990
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.52027
Product name
Fmoc-α-t-butylglycine
Purity
Novabiochem?
Packaging
1g
Price
$181
Updated
2025/07/31
Sigma-Aldrich
Product number
8.52027
Product name
Fmoc-α-t-butylglycine
Purity
Novabiochem?
Packaging
5G
Price
$713
Updated
2025/07/31
Sigma-Aldrich
Product number
47524
Product name
Fmoc-tBu-Gly-OH
Purity
≥98.0%
Packaging
1g
Price
$306
Updated
2025/07/31
TCI Chemical
Product number
F1251
Product name
N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-tert-leucine
Packaging
5G
Price
$53
Updated
2025/07/31
TCI Chemical
Product number
F1251
Product name
N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-tert-leucine
Packaging
25G
Price
$212
Updated
2025/07/31
More
Less

Fmoc-L-tert-leucine Chemical Properties,Usage,Production

Chemical Properties

solid

Uses

Fmoc-Tle-OH is a versatile reactant used in the discovery of potent antagonists of antiapoptotic protein X-linked inhibitor of apoptosis (XIAP) for treatment of cancer. It is also used as reactant in the preparation of phosphino dipeptide derivatices as ligand in copper-phosphine catalyst for asymmetric conjugate addition of alkylzinc reagents to unsaturated ketones.

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

Synthesis

20859-02-3

28920-43-6

132684-60-7

General procedure for the synthesis of Fmoc-L-tert-leucine from L-tert-leucine and 9-fluorenylmethyl chloroformate: a 500 mL reaction flask was taken and to it was added L-tert-leucine (5.1 g, 38.6 mmol), dioxane (40 mL), and 10% sodium carbonate solution (100 mL). The reaction flask was placed in an ice bath and a dioxane solution (100 mL) of methyl chloroformate-9-fluorenyl (10.0 g, 38.6 mmol) was slowly added through a dropping funnel under mechanical stirring. After dropwise addition, the solution was gradually returned to room temperature and stirring was continued overnight. After completion of the reaction, 100 mL of water was added and extracted three times with 50 mL of ether, retaining the aqueous phase. The aqueous phase was cooled in an ice bath and the pH was adjusted slowly to 1 by adding 1 M dilute hydrochloric acid. subsequently, the aqueous solution was extracted three times with 50 mL of ethyl acetate. The organic phases were combined, dried with anhydrous magnesium sulfate, filtered and concentrated to dryness to give the intermediate Fmoc-L-tert-leucine (14.3 g, 96% yield).

References

[1] Patent: CN106588987, 2017, A. Location in patent: Paragraph 0195; 0196; 0197
[2] Angewandte Chemie - International Edition, 2013, vol. 52, # 45, p. 11846 - 11851
[3] Angew. Chem., 2013, vol. 125, # 45, p. 12062 - 12067,6
[4] Chemistry - A European Journal, 2014, vol. 20, # 21, p. 6526 - 6531
[5] Patent: WO2018/145021, 2018, A1. Location in patent: Page/Page column 134

Fmoc-L-tert-leucine Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Fmoc-L-tert-leucine Suppliers

Americas 1 China 164 Europe 2 France 1 Germany 4 India 2 Japan 2 Switzerland 2 United Kingdom 4 United States 18 Global 200
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94644
Advantage
76
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44801
Advantage
61
GL Biochem (Shanghai) Ltd
Tel
21-61263452 13641803416
Fax
86-21-61263399
Email
ymbetter@glbiochem.com
Country
China
ProdList
9981
Advantage
64
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9309
Advantage
66
Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Fax
021-50795055
Email
sales@accelachem.com
Country
China
ProdList
11035
Advantage
64
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
16077
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42934
Advantage
64
Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
15402
Advantage
60
Shandong Xiya Chemical Co., Ltd
Tel
4009903999 13355009207
Fax
0539-6365991
Email
3007715519@qq.com
Country
China
ProdList
18729
Advantage
57
Lavem Chine Pharm Company
Tel
028-62070218 18190869852
Fax
86-28-8527-5264
Email
sales@lavemc.com
Country
China
ProdList
214
Advantage
67
Hunan Hui Bai Shi Biotechnology Co., Ltd.
Tel
0731-85526065 13308475853
Email
ivy@hnhbsj.com
Country
China
ProdList
7247
Advantage
62
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12335
Advantage
58
Shanghai Jian Chao Chemical Technology Co., Ltd.
Tel
150-2103-5486 18017383231
Fax
qq：2817624287
Email
983544897@qq.com
Country
China
ProdList
9342
Advantage
55
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
18209
Advantage
56
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-6206333 13167063860
Fax
021-50323701
Email
anhua.mao@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
TargetMol Chemicals Inc.
Tel
021-021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7783
Advantage
58
Amatek Scientific Co. Ltd.
Tel
0512-56316828 4008675858
Fax
+86-512-56316826
Email
sales@amateksci.com
Country
China
ProdList
9874
Advantage
55
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
39966
Advantage
60
Finetech Industry Limited
Tel
027-87465837 19945049750
Fax
027-8777-2287
Email
sales@finetechnology-ind.com
Country
China
ProdList
9637
Advantage
58
Shanghai Aspire Biological Technology Co., Ltd.
Tel
021-61317773
Fax
021-61486878
Email
sales@aspirebio.com
Country
China
ProdList
2880
Advantage
58
Shanghai Balmxy Pharmaceutical Co., Ltd
Tel
021-24206007 13764915196
Fax
86-021-23027023
Email
sales@balmxy.com
Country
China
ProdList
6874
Advantage
55
NINGBO INNO PHARMCHEM CO.,LTD.
Tel
86-574-27787657
Fax
86-574-27912196
Email
info@dearchem.com
Country
China
ProdList
4613
Advantage
58
Shanghai HuanChuan Industry Co.,Ltd.
Tel
021-61478794
Fax
021-61478794
Email
sales@hcshhai.com
Country
China
ProdList
9793
Advantage
50
Cool Pharm, Ltd
Tel
021-60455363 18019463053
Fax
50966098
Email
sales@coolpharm.com
Country
China
ProdList
12346
Advantage
58
Hubei Jusheng Technology Co.,Ltd
Tel
027-59599241 18871490274
Fax
027-59599241
Email
1400878000@qq.com
Country
China
ProdList
9858
Advantage
58
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51395
Advantage
80
Quzhou Rundong Chemical (Technology) Co.
Tel
0570-8789886 18892685668
Fax
0570-8789985
Email
info@rundongchemical.com
Country
China
ProdList
4053
Advantage
60
Taizhou Tianhong Biochemistry Technology Co., Ltd.
Tel
0523-86132544 15366717810
Fax
0523-86201489
Email
sales@thbiochem.com
Country
China
ProdList
375
Advantage
55
Zhengzhou Alfachem Co., Ltd.
Tel
0371-53765687 18937137882
Fax
QQ:2885373884
Email
2853979813@qq.com
Country
China
ProdList
7991
Advantage
55
Codow Chemical Co.,Ltd.
Tel
18620099427
Fax
+86-20-62619665
Email
amy@howeipharm.com
Country
China
ProdList
6687
Advantage
55
Shanghai GL Peptide Ltd.
Tel
+86-21-61263340; 17609490614 13764994101
Fax
021-61263399
Email
fisherwang@glschina.com
Country
China
ProdList
8258
Advantage
55
Shanghai Haozhixiang Biotechnology Co., Ltd
Tel
526763801 13301653310
Fax
+86-21-51619052
Email
526763801@qq.com
Country
China
ProdList
9288
Advantage
55
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Shanghai Changyan Chem & Tech Co., Ltd.
Tel
021-20242659 18930833303
Fax
+86 (21) 2024-2659
Email
Sales@changyanchem.cn
Country
China
ProdList
5001
Advantage
55
Chengdu Huachun Technology Co., Ltd
Tel
400-1166-196 15982826727
Fax
QQ：800101999
Email
cdhxsj@163.com
Country
China
ProdList
14603
Advantage
60
Wuxi Asia Peptide Biotechnology Limited Company
Tel
0510-83583050 13771062561
Fax
0510-83583039
Email
willsun@peptide-search.com
Country
China
ProdList
6716
Advantage
58
Suzhou ShangXin Biochemical Technology Co., Ltd.
Tel
0512-53995928 13862342518
Fax
0512-53995928
Email
fyju@sxbiochem.com
Country
China
ProdList
200
Advantage
58
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Nanjing Peptide Biotech Ltd.
Tel
025-58361106-805 15951641583
Fax
025-58361106-806
Email
zhao.xu@njpeptide.com
Country
China
ProdList
9979
Advantage
55
Siling(shanghai) chemical Technology Co., Ltd.
Tel
021-64149925
Fax
021-64149925
Email
13761470417@163.com
Country
China
ProdList
220
Advantage
55
Taian Jiaye Biotechnology Co.Ltd
Tel
13127280945
Email
285424065@qq.com
Country
China
ProdList
9976
Advantage
55
Sichuan jiayinglai technology CO.,LTD
Tel
028-028-88457210 18190964009
Fax
QQ3213375147
Email
3054240163@qq.com
Country
China
ProdList
2293
Advantage
55
JinJin Le Chemical Co., Ltd
Tel
18001959627(微信同号) 18001959627
Email
jjlchem2@163.com
Country
China
ProdList
9981
Advantage
58
Shanghai BaiShun Biological Technology Co., Ltd
Tel
021-37581181
Fax
021-57456066
Email
sales@chem-mall.com
Country
China
ProdList
10330
Advantage
58
Wuxi AppTec
Tel
022-59987777 13552403979
Email
jia_guoqiang@wuxiapptec.com
Country
China
ProdList
22345
Advantage
58
Shanghai Zhen Li Biological Technology Co., Ltd
Tel
021-16621358918; 18516310516
Fax
13045646768
Email
zhenlipharma888@163.com
Country
China
ProdList
19035
Advantage
58
Aikon International Limited
Tel
025-58859352 18068836627
Fax
02557626880
Email
sales01@aikonchem.com
Country
China
ProdList
16027
Advantage
58
Shanghai Haohong Pharmaceutical Co., Ltd.
Tel
400-8210725 400821072
Fax
021-58955996
Email
malulu@leyan.com
Country
China
ProdList
25000
Advantage
58
3A Chemicals
Tel
400-668-9898
Fax
010-51582189
Email
service@3achem.com
Country
China
ProdList
20557
Advantage
58
Shanghai Jizhi Biochemical Technology Co. Ltd.
Tel
4009004166/18616739031 18616739031
Email
3007523370@qq.com
Country
China
ProdList
52687
Advantage
58
More
Less

View Lastest Price from Fmoc-L-tert-leucine manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd
Product
Fmoc-L-Tle-OH 132684-60-7
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1T
Release date
2023-11-29
Career Henan Chemical Co
Product
Fmoc-L-tert-leucine 132684-60-7
Price
US $9.80/KG
Min. Order
1g
Purity
≥99%
Supply Ability
100kg
Release date
2020-01-03

132684-60-7, Fmoc-L-tert-leucineRelated Search:

N-CARBOBENZOXY-DL-LEUCINE Glycine Nalpha-Fmoc-Ndelta-trityl-L-glutamine tert-Butyl peroxyacetate Fmoc-Phe-OH 9-Fluorenylmethyl chloroformate METHOXYCARBONYLSULFENYL CHLORIDE Fmoc-Lys(Boc)-OH L-Fmoc-Aspartic acid alpha-tert-butyl ester tert-Butanol 6-Aminocaproic acid FMOC-L-Valine tert-Butyl acetate Fmoc-Asp(OtBu)-OH L-tert-Leucine Fmoc-OSu DL-Leucine FMOC-N-Methyl-L-alanine

  • (S)-N-FMOC-2-AMINO-3,3-DIMETHYL BUTANOIC ACID
  • RARECHEM EM WB 0083
  • N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-L-TERT-BUTYL-GLYCINE
  • N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-L-T-LEUCINE
  • N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-(S)-2-AMINO-3,3-DIMETHYL-BUTYRIC ACID
  • FMOC-L-TLE-OH
  • FMOC-L-T-BUTYLGLYCINE
  • FMOC-L-TERT-LEUCINE
  • FMOC-TLE-OH
  • FMOC-TBU-GLYCINE
  • FMOC-TBU-GLY-OH
  • FMOC-ALPHA-T-BUTYL-GLY-OH
  • FMOC-ALPHA-T-BUTYLGLYCINE
  • FMOC-L-ALPHA-T-BUTYLGLYCINE
  • N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-L-ALPHA-T-BUTYLGLYCINE
  • N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-L-TERT-LEUCINE
  • N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-L-T-LEUCINE
  • N-ALPHA-FMOC-L-T-BUTYLGLYCINE
  • N-ALPHA-FMOC-L-T-LEUCINE
  • N-ALPHA-FMOC-L-ALPHA-T-BUTYL-GLYCINE
  • N-ALPHA-T-FMOC-L-ALPHA-T-BUTYL-GLYCINE
  • N-ALPHA-T-FMOC-L-T-LEUCINE
  • N-alpha-(9-Fluorenylmethyloxycarbonyl)-L-t-leucine, N-alpha-(9-Fluorenylmethyloxycarbonyl)-L-t-butyl-glycine
  • (S)-2-(((9H-fluoren-9-yl)methoxy)carbonyl)-3,3-dim
  • (S)-N-Fmoc-2-amino-3,3-dimethyl-butyric acid
  • N-9-Fluorenylmethoxycarbonyl-L-tert-leucine
  • Fmoc-L-tert-leucine, Fmoc-Tle-OH
  • FMoc-Tle-OH (FMoc-tertleucine)
  • (S)-2-((((9H-Fluoren-9-yl)Methoxy)carbonyl)aMino)-3,3-diMethylbutanoic acid
  • FMOC-L-T-LEUCINE
  • Fmoc-L-α-tert-butylglycine
  • Fmoc-L-α-tert-butylglycine≥ 99% (HPLC)
  • (2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3,3-dimethylbutanoic acid
  • Fmoc-tBu-Gly-OH, ≥98.0%
  • Fmoc-L-α-tert-butyl-Gly-OH
  • Fmoc-α-t-butylglycine Novabiochem
  • (9H-Fluoren-9-yl)MethOxy]Carbonyl Tle-OH
  • L-Valine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-3-methyl-
  • N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-tert-leucine
  • (S)-2-(Fmoc-amino)-3,3-dimethylbutyric Acid
  • N-Fmoc-L-tert-leucine
  • Fmoc-L-tert-leucine USP/EP/BP
  • Fmoc-L-alpha-t-butylglycine - 1 g
  • N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-methyl-L-valine
  • 132684-60-7
  • Leucine Derivatives
  • Peptide Synthesis
  • Unnatural Amino Acid Derivatives
  • Specialty Synthesis
  • Amino Acids & Deriv.
  • CHIRAL CHEMICALS
  • Peptide
  • API intermediates
  • Amino Acids