FMOC-N-Methyl-L-alanine

Product Name: FMOC-N-Methyl-L-alanine
CAS No.: 84000-07-7
Chemical Name: FMOC-N-Methyl-L-alanine
Synonyms: FMOC-MEALA-OH;FMOC-L-MEALA-OH;FMOC-N-ME-ALA-OH;FMOC-N-ME-L-ALA-OH;Fmoc-L-N-Me-Ala-OH;Fmoc-N-Me-L-Alanine;Fmoc-N-Me-DL-Alanine;FMOC-N-ME-ALA 98.5+%;FMOC-N-METHYL-L-ALANINE;Fmoc-N-Me-Ala-OH
CBNumber: CB0495149
Molecular Formula: C19H19NO4
Formula Weight: 325.36
MOL File: 84000-07-7.mol

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FMOC-N-Methyl-L-alanine Property

Melting point:: ~150 °C
alpha: -18.5 º (c=1,DMF)
Boiling point:: 514.9±29.0 °C(Predicted)
Density: 1.262±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Soluble in water or 1% acetic acid
pka: 3.92±0.10(Predicted)
form: Solid
color: White to Almost white
optical activity: [α]20/D 18.5±1°, c = 1% in DMF
Water Solubility: Slightly soluble in water.
BRN: 4329998
Sequence: Fmoc-N-Me-Ala-OH
InChIKey: JOFHWKQIQLPZTC-LBPRGKRZSA-N
CAS DataBase Reference: 84000-07-7(CAS DataBase Reference)

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Safety

Safety Statements: 22-24/25
WGK Germany: 3
HS Code: 2924 29 70
HazardClass: IRRITANT

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 8.52138
Product name: Fmoc-N-Me-Ala-OH
Purity: Novabiochem?
Packaging: 1g
Price: $119
Updated: 2025/07/31

Sigma-Aldrich

Product number: 8.52138
Product name: Fmoc-N-Me-Ala-OH
Purity: Novabiochem?
Packaging: 5G
Price: $462
Updated: 2025/07/31

Sigma-Aldrich

Product number: 47594
Product name: Fmoc-N-Me-Ala-OH
Purity: ≥97.0% (sum of enantiomers, HPLC)
Packaging: 1G
Price: $107
Updated: 2025/07/31

TCI Chemical

Product number: F1164
Product name: N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-L-alanine
Packaging: 5G
Price: $55
Updated: 2025/07/31

TRC

Product number: F679778
Product name: Fmoc-N-methyl-L-Alanine
Packaging: 1g
Price: $75
Updated: 2021/12/16

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FMOC-N-Methyl-L-alanine Chemical Properties,Usage,Production

Chemical Properties

White to off white powder

Uses

It is a important organic intermediate. It can be used in agrochemical, pharmaceutical and dyestuff field. Also used in N-methyl amino acids for peptide synthesis.

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

Synthesis

83999-95-5

84000-07-7

The general procedure for the synthesis of Fmoc-N-methyl-L-alanine from the compound (CAS: 83999-95-5) was as follows: paraformaldehyde (4.0 g, 133 mmol) and p-toluenesulfonic acid (0.5 g, 13.3 mmol) were added to a suspension of Fmoc-L-alanine (6.2 g, 19.9 mmol) in toluene (400 mL). The mixture was refluxed for 30 min to remove azeotropic water. The solution was cooled, washed with 1 M aqueous NaHCO3 (2 x 100 mL) and dried with Na2SO4. Subsequently, the solution was concentrated in vacuum to give a white solid. The above oxazolidinone was dissolved in chloroform (75 mL) and trifluoroacetic acid (75 mL) and triethylsilane (7.2 mL, 44.8 mmol) were added. The reaction mixture was stirred at room temperature for 10 hours and then concentrated under vacuum. The resulting oily substance was dissolved in dichloromethane and the concentration was repeated three times. After standing, the oily substance crystallized. The crystals were redissolved in ether and concentrated. Finally, the collected white solid was washed with 5% ether/hexane and dried to give the product (6.1 g, 94% yield).

References

[1] Tetrahedron Letters, 2011, vol. 52, # 30, p. 3872 - 3875
[2] European Journal of Organic Chemistry, 2013, # 21, p. 4509 - 4513
[3] Journal of Organic Chemistry, 2005, vol. 70, # 17, p. 6918 - 6920
[4] Tetrahedron Letters, 2006, vol. 47, # 11, p. 1691 - 1694
[5] Tetrahedron Letters, 2014, vol. 55, # 44, p. 6109 - 6112

FMOC-N-Methyl-L-alanine Preparation Products And Raw materials

Raw materials

Preparation Products

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FMOC-N-Methyl-L-alanine Suppliers

Americas 1 China 206 Europe 1 Germany 5 India 4 Japan 3 Switzerland 2 United Kingdom 8 United States 38 Global 268

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View Lastest Price from FMOC-N-Methyl-L-alanine manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: Fmoc-L-N-Me-Ala-OH 84000-07-7
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1T+
Release date: 2024-04-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: FMOC-N-Methyl-L-alanine 84000-07-7
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

Sichuan Jiaying Lai Technology Co.,LTD

Product: Fmoc-N-Me-Ala-OH 84000-07-7
Price: US $1.00/g
Min. Order: 1g
Purity: 98%
Supply Ability: 100KG
Release date: 2019-07-23

84000-07-7, FMOC-N-Methyl-L-alanineRelated Search:

N-Methyl-L-alanine FMOC-Ala-OH Methyl salicylate Fmoc-Lys(Boc)-OH Methyl acrylate Methanol Kresoxim-methyl DL-Alanine D-Alanine β-Alanine L-Fmoc-Aspartic acid alpha-tert-butyl ester 9-Fluorenylmethyl chloroformate EC 2.6.1.2 FMOC-b-Ala-OH L-Alanine Phenprobamate Fmoc-Phe-OH Fmoc-Asp(OtBu)-OH

(2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}(methyl)amino)propanoic acid

Fmoc-N-Me-DL-Alanine

Fmoc-N-methyl-L-alanine≥ 99% (HPLC)

(9H-Fluoren-9-yl)MethOxy]Carbonyl N-Me-Ala-OH

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-L-alanine

(S)-2-((((9H-Fluoren-9-yl)Methoxy)carbonyl)(Methyl)aMino)propanoic acid

N-FMoc-N-Methyl-L-alanine, 95%

Fmoc-N-Me-L-Alanine

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FMOC-N-ALPHA-METHYL-L-ALANINE

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FMOC-N-ME-L-ALA-OH

N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-N-ALPHA-METHYL-L-ALANINE

N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-N-ALPHA-METHYL-L-ALANINE

N-ALPHA-FMOC-N-ALPHA-METHYL-L-ALANINE

Nα-(9-Fluorenylmethyloxycarbonyl)-Nα-methyl-L-alanine ,98%

FMOC-N-ME-ALA 98.5+%

Fmoc-N-Me-Ala-OH Fmoc-N-methyl-L-Alanine

L-Alanine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N-methyl-

FMOC-N-Methyl-L-alanine USP/EP/BP

Fmoc-L-N-Me-Ala-OH

FMoc-N-α-Methyl-L-alanine

N-(9-fluorenylmethoxycarbonyl)-N-methyl-L-alanine

Fmoc-N-Me-Ala-OH, 10 mM in DMSO

Fmoc-<i>N</i>-Me-Ala-OH

(2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]propanoic acid - [F73034]

N-Fmoc-N-methyl-L-alanine

84000-07-7

C19H19NO4

Peptide Synthesis

N-Methyl Amino Acids

Specialty Synthesis

Unnatural Amino Acid Derivatives

Amino Acids

Alanine [Ala, A]

N-Methyl Amino Acids

Fmoc-Amino acid series