FMOC-N-Methyl-L-alanine
- Product Name
- FMOC-N-Methyl-L-alanine
- CAS No.
- 84000-07-7
- Chemical Name
- FMOC-N-Methyl-L-alanine
- Synonyms
- FMOC-MEALA-OH;FMOC-L-MEALA-OH;FMOC-N-ME-ALA-OH;FMOC-N-ME-L-ALA-OH;Fmoc-L-N-Me-Ala-OH;Fmoc-N-Me-L-Alanine;Fmoc-N-Me-DL-Alanine;FMOC-N-ME-ALA 98.5+%;FMOC-N-METHYL-L-ALANINE;Fmoc-N-Me-Ala-OH
- CBNumber
- CB0495149
- Molecular Formula
- C19H19NO4
- Formula Weight
- 325.36
- MOL File
- 84000-07-7.mol
FMOC-N-Methyl-L-alanine Property
- Melting point:
- ~150 °C
- alpha
- -18.5 º (c=1,DMF)
- Boiling point:
- 514.9±29.0 °C(Predicted)
- Density
- 1.262±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- Soluble in water or 1% acetic acid
- pka
- 3.92±0.10(Predicted)
- form
- Solid
- color
- White to Almost white
- optical activity
- [α]20/D 18.5±1°, c = 1% in DMF
- Water Solubility
- Slightly soluble in water.
- BRN
- 4329998
- Sequence
- Fmoc-N-Me-Ala-OH
- InChIKey
- JOFHWKQIQLPZTC-LBPRGKRZSA-N
- CAS DataBase Reference
- 84000-07-7(CAS DataBase Reference)
Safety
- Safety Statements
- 22-24/25
- WGK Germany
- 3
- HS Code
- 2924 29 70
- HazardClass
- IRRITANT
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 8.52138
- Product name
- Fmoc-N-Me-Ala-OH
- Purity
- Novabiochem?
- Packaging
- 1g
- Price
- $119
- Updated
- 2025/07/31
- Product number
- 8.52138
- Product name
- Fmoc-N-Me-Ala-OH
- Purity
- Novabiochem?
- Packaging
- 5G
- Price
- $462
- Updated
- 2025/07/31
- Product number
- 47594
- Product name
- Fmoc-N-Me-Ala-OH
- Purity
- ≥97.0% (sum of enantiomers, HPLC)
- Packaging
- 1G
- Price
- $107
- Updated
- 2025/07/31
- Product number
- F1164
- Product name
- N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-L-alanine
- Packaging
- 5G
- Price
- $55
- Updated
- 2025/07/31
- Product number
- F679778
- Product name
- Fmoc-N-methyl-L-Alanine
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
FMOC-N-Methyl-L-alanine Chemical Properties,Usage,Production
Chemical Properties
White to off white powder
Uses
It is a important organic intermediate. It can be used in agrochemical, pharmaceutical and dyestuff field. Also used in N-methyl amino acids for peptide synthesis.
reaction suitability
reaction type: Fmoc solid-phase peptide synthesis
Synthesis
83999-95-5
84000-07-7
The general procedure for the synthesis of Fmoc-N-methyl-L-alanine from the compound (CAS: 83999-95-5) was as follows: paraformaldehyde (4.0 g, 133 mmol) and p-toluenesulfonic acid (0.5 g, 13.3 mmol) were added to a suspension of Fmoc-L-alanine (6.2 g, 19.9 mmol) in toluene (400 mL). The mixture was refluxed for 30 min to remove azeotropic water. The solution was cooled, washed with 1 M aqueous NaHCO3 (2 x 100 mL) and dried with Na2SO4. Subsequently, the solution was concentrated in vacuum to give a white solid. The above oxazolidinone was dissolved in chloroform (75 mL) and trifluoroacetic acid (75 mL) and triethylsilane (7.2 mL, 44.8 mmol) were added. The reaction mixture was stirred at room temperature for 10 hours and then concentrated under vacuum. The resulting oily substance was dissolved in dichloromethane and the concentration was repeated three times. After standing, the oily substance crystallized. The crystals were redissolved in ether and concentrated. Finally, the collected white solid was washed with 5% ether/hexane and dried to give the product (6.1 g, 94% yield).
References
[1] Tetrahedron Letters, 2011, vol. 52, # 30, p. 3872 - 3875
[2] European Journal of Organic Chemistry, 2013, # 21, p. 4509 - 4513
[3] Journal of Organic Chemistry, 2005, vol. 70, # 17, p. 6918 - 6920
[4] Tetrahedron Letters, 2006, vol. 47, # 11, p. 1691 - 1694
[5] Tetrahedron Letters, 2014, vol. 55, # 44, p. 6109 - 6112
FMOC-N-Methyl-L-alanine Preparation Products And Raw materials
Raw materials
Preparation Products
FMOC-N-Methyl-L-alanine Suppliers
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View Lastest Price from FMOC-N-Methyl-L-alanine manufacturers
- Product
- Fmoc-L-N-Me-Ala-OH 84000-07-7
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1T+
- Release date
- 2024-04-10
- Product
- FMOC-N-Methyl-L-alanine 84000-07-7
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11
- Product
- Fmoc-N-Me-Ala-OH 84000-07-7
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2019-07-23