ChemicalBook > CAS DataBase List > FMOC-N-Methyl-L-alanine

FMOC-N-Methyl-L-alanine

Product Name
FMOC-N-Methyl-L-alanine
CAS No.
84000-07-7
Chemical Name
FMOC-N-Methyl-L-alanine
Synonyms
FMOC-MEALA-OH;FMOC-L-MEALA-OH;FMOC-N-ME-ALA-OH;FMOC-N-ME-L-ALA-OH;Fmoc-L-N-Me-Ala-OH;Fmoc-N-Me-L-Alanine;Fmoc-N-Me-DL-Alanine;FMOC-N-ME-ALA 98.5+%;FMOC-N-METHYL-L-ALANINE;Fmoc-N-Me-Ala-OH
CBNumber
CB0495149
Molecular Formula
C19H19NO4
Formula Weight
325.36
MOL File
84000-07-7.mol
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FMOC-N-Methyl-L-alanine Property

Melting point:
~150 °C
alpha 
-18.5 º (c=1,DMF)
Boiling point:
514.9±29.0 °C(Predicted)
Density 
1.262±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
Soluble in water or 1% acetic acid
pka
3.92±0.10(Predicted)
form 
Solid
color 
White to Almost white
optical activity
[α]20/D 18.5±1°, c = 1% in DMF
Water Solubility 
Slightly soluble in water.
BRN 
4329998
Sequence
Fmoc-N-Me-Ala-OH
InChIKey
JOFHWKQIQLPZTC-LBPRGKRZSA-N
CAS DataBase Reference
84000-07-7(CAS DataBase Reference)
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
HS Code 
2924 29 70
HazardClass 
IRRITANT
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.52138
Product name
Fmoc-N-Me-Ala-OH
Purity
Novabiochem?
Packaging
1g
Price
$119
Updated
2025/07/31
Sigma-Aldrich
Product number
8.52138
Product name
Fmoc-N-Me-Ala-OH
Purity
Novabiochem?
Packaging
5G
Price
$462
Updated
2025/07/31
Sigma-Aldrich
Product number
47594
Product name
Fmoc-N-Me-Ala-OH
Purity
≥97.0% (sum of enantiomers, HPLC)
Packaging
1G
Price
$107
Updated
2025/07/31
TCI Chemical
Product number
F1164
Product name
N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-L-alanine
Packaging
5G
Price
$55
Updated
2025/07/31
TRC
Product number
F679778
Product name
Fmoc-N-methyl-L-Alanine
Packaging
1g
Price
$75
Updated
2021/12/16
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FMOC-N-Methyl-L-alanine Chemical Properties,Usage,Production

Chemical Properties

White to off white powder

Uses

It is a important organic intermediate. It can be used in agrochemical, pharmaceutical and dyestuff field. Also used in N-methyl amino acids for peptide synthesis.

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

Synthesis

83999-95-5

84000-07-7

The general procedure for the synthesis of Fmoc-N-methyl-L-alanine from the compound (CAS: 83999-95-5) was as follows: paraformaldehyde (4.0 g, 133 mmol) and p-toluenesulfonic acid (0.5 g, 13.3 mmol) were added to a suspension of Fmoc-L-alanine (6.2 g, 19.9 mmol) in toluene (400 mL). The mixture was refluxed for 30 min to remove azeotropic water. The solution was cooled, washed with 1 M aqueous NaHCO3 (2 x 100 mL) and dried with Na2SO4. Subsequently, the solution was concentrated in vacuum to give a white solid. The above oxazolidinone was dissolved in chloroform (75 mL) and trifluoroacetic acid (75 mL) and triethylsilane (7.2 mL, 44.8 mmol) were added. The reaction mixture was stirred at room temperature for 10 hours and then concentrated under vacuum. The resulting oily substance was dissolved in dichloromethane and the concentration was repeated three times. After standing, the oily substance crystallized. The crystals were redissolved in ether and concentrated. Finally, the collected white solid was washed with 5% ether/hexane and dried to give the product (6.1 g, 94% yield).

References

[1] Tetrahedron Letters, 2011, vol. 52, # 30, p. 3872 - 3875
[2] European Journal of Organic Chemistry, 2013, # 21, p. 4509 - 4513
[3] Journal of Organic Chemistry, 2005, vol. 70, # 17, p. 6918 - 6920
[4] Tetrahedron Letters, 2006, vol. 47, # 11, p. 1691 - 1694
[5] Tetrahedron Letters, 2014, vol. 55, # 44, p. 6109 - 6112

FMOC-N-Methyl-L-alanine Preparation Products And Raw materials

Raw materials

Preparation Products

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FMOC-N-Methyl-L-alanine Suppliers

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View Lastest Price from FMOC-N-Methyl-L-alanine manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd
Product
Fmoc-L-N-Me-Ala-OH 84000-07-7
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1T+
Release date
2024-04-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
FMOC-N-Methyl-L-alanine 84000-07-7
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11
Sichuan Jiaying Lai Technology Co.,LTD
Product
Fmoc-N-Me-Ala-OH 84000-07-7
Price
US $1.00/g
Min. Order
1g
Purity
98%
Supply Ability
100KG
Release date
2019-07-23

84000-07-7, FMOC-N-Methyl-L-alanineRelated Search:

N-Methyl-L-alanine FMOC-Ala-OH Methyl salicylate Fmoc-Lys(Boc)-OH Methyl acrylate Methanol Kresoxim-methyl DL-Alanine D-Alanine β-Alanine L-Fmoc-Aspartic acid alpha-tert-butyl ester 9-Fluorenylmethyl chloroformate EC 2.6.1.2 FMOC-b-Ala-OH L-Alanine Phenprobamate Fmoc-Phe-OH Fmoc-Asp(OtBu)-OH

  • (2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}(methyl)amino)propanoic acid
  • Fmoc-N-Me-DL-Alanine
  • Fmoc-N-methyl-L-alanine≥ 99% (HPLC)
  • (9H-Fluoren-9-yl)MethOxy]Carbonyl N-Me-Ala-OH
  • N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-L-alanine
  • (S)-2-((((9H-Fluoren-9-yl)Methoxy)carbonyl)(Methyl)aMino)propanoic acid
  • N-FMoc-N-Methyl-L-alanine, 95%
  • Fmoc-N-Me-L-Alanine
  • FMOC-L-MEALA-OH
  • FMOC-N-ALPHA-METHYL-L-ALANINE
  • FMOC-MEALA-OH
  • FMOC-N-METHYL-L-ALANINE
  • FMOC-N-ME-ALA-OH
  • FMOC-N-ME-L-ALA-OH
  • N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-N-ALPHA-METHYL-L-ALANINE
  • N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-N-ALPHA-METHYL-L-ALANINE
  • N-ALPHA-FMOC-N-ALPHA-METHYL-L-ALANINE
  • Nα-(9-Fluorenylmethyloxycarbonyl)-Nα-methyl-L-alanine ,98%
  • FMOC-N-ME-ALA 98.5+%
  • Fmoc-N-Me-Ala-OH Fmoc-N-methyl-L-Alanine
  • L-Alanine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N-methyl-
  • FMOC-N-Methyl-L-alanine USP/EP/BP
  • Fmoc-L-N-Me-Ala-OH
  • FMoc-N-α-Methyl-L-alanine
  • N-(9-fluorenylmethoxycarbonyl)-N-methyl-L-alanine
  • Fmoc-N-Me-Ala-OH, 10 mM in DMSO
  • Fmoc-<i>N</i>-Me-Ala-OH
  • (2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]propanoic acid - [F73034]
  • N-Fmoc-N-methyl-L-alanine
  • 84000-07-7
  • C19H19NO4
  • Peptide Synthesis
  • N-Methyl Amino Acids
  • Specialty Synthesis
  • Unnatural Amino Acid Derivatives
  • Amino Acids
  • Alanine [Ala, A]
  • N-Methyl Amino Acids
  • Fmoc-Amino acid series