Isopropyl unoprostone
- Product Name
- Isopropyl unoprostone
- CAS No.
- 120373-24-2
- Chemical Name
- Isopropyl unoprostone
- Synonyms
- UF-021;Rescul;RESCULA;Unii-5m161S5o5p;ISOPROPY UNOPROSTONE;isopropyl unoprostone;UNOPROSTONE ISOPROPYL ESTER;Isopropyl unoprostone USP/EP/BP;Uroprostaglandin isopropyl ester;13,14-dihydro-15-keto-20-ethyl-pgf
- CBNumber
- CB1392171
- Molecular Formula
- C25H44O5
- Formula Weight
- 424.61
- MOL File
- 120373-24-2.mol
Isopropyl unoprostone Property
- Boiling point:
- 546.3±45.0 °C(Predicted)
- Density
- 1.019±0.06 g/cm3(Predicted)
- storage temp.
- -20°C Freezer
- solubility
- Chloroform (Slightly), Ethyl Acetate (Slightly)
- form
- Oil
- pka
- 14.79±0.70(Predicted)
- color
- Clear Colourless
- CAS DataBase Reference
- 120373-24-2(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
H302Harmful if swallowed
H319Causes serious eye irritation
H336May cause drowsiness or dizziness
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242Use only non-sparking tools.
P243Take precautionary measures against static discharge.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P330Rinse mouth.
P337+P313IF eye irritation persists: Get medical advice/attention.
P370+P378In case of fire: Use … for extinction.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P403+P235Store in a well-ventilated place. Keep cool.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 16681
- Product name
- Unoprostone isopropyl ester
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $57
- Updated
- 2024/03/01
- Product number
- 16681
- Product name
- Unoprostone isopropyl ester
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $257
- Updated
- 2024/03/01
- Product number
- 16681
- Product name
- Unoprostone isopropyl ester
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $456
- Updated
- 2024/03/01
- Product number
- 16681
- Product name
- Unoprostone isopropyl ester
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $1853
- Updated
- 2024/03/01
- Product number
- U800050
- Product name
- UnoprostoneIsopropylEster
- Packaging
- 5mg
- Price
- $880
- Updated
- 2021/12/16
Isopropyl unoprostone Chemical Properties,Usage,Production
Description
Unoprostone isopropyl ester, a novel prostaglandin derivative, was launched in Japan as eye drops for the treatment of glaucoma and ocular hypertension. In animal and human studies, a single drop of unoprostone isopropyl ester induced significant decrease in intraocular pressure without systemic effects, myosis or mydriasis. Unlike prostaglandin analogs such as PGF2α, unoprostone isopropyl ester does not cause irritation in outer segment of the eye or significant changes in aqueous protein concentration and corneal endothelial permeability. Unoprostone isopropyl ester is suggested to act by increasing uveoscleral outflow or by decreasing episcleral venous pressure, resulting in ocular hypotension.
Description
Unoprostone isopropyl ester (Rescula) is the clinically approved, prodrug form of unoprostone, which is a free acid analog of prostaglandin F2α (PGF2α). Both latanoprost and Rescula have been approved for the treatment of ocular hypertension. Both analogs of PGF2α are believed to act by increasing the rate of aqueous humor outflow through the uveoscleral pathway. Both drugs are believed to act as prodrugs, with endogenous esterases within the eye releasing the free acid active form of the drug. The typical does of Rescula (one drop of 0.12% solution) is nearly 100 times that of latanoprost. Rescula has very little activity on isolated DP or TP receptors, less than 0.0005% the activity of PGE2 on EP3 receptors, and about 3% of the activity of PGF2α on FP receptors.
Chemical Properties
Clear Colourless Oil
Originator
Ueno (Japan)
Uses
Antiglaucoma; used in treatment of ocular hypertension.
Uses
Isopropyl unoprostone is an antiglaucoma,it is used in treatment of ocular hypertension.
Definition
ChEBI: A carboxylic ester that is the isopropyl ester of unoprostone.
brand name
Rescuia
Hazard
A poison.
Isopropyl unoprostone Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Isopropyl unoprostone manufacturers
- Product
- Isopropyl unoprostone 120373-24-2
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-05-26
- Product
- Isopropyl unoprostone 120373-24-2
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200KG
- Release date
- 2019-07-01