ChemicalBook > CAS DataBase List > Boc-N-Me-Val-OH

Boc-N-Me-Val-OH

Product Name
Boc-N-Me-Val-OH
CAS No.
45170-31-8
Chemical Name
Boc-N-Me-Val-OH
Synonyms
Boc-N-me-Val;BOC-N-ME-VAL-OH;Boc-L-N-Me-Val-OH;BOC-MEVAL-OH;BOC-L-MEVAL-OH;BOC-N-ME-VALINE;)amino)-3-methyL;Boc-N-Me-L-Val-OH;N-Boc-N-methylvaline;BOC-N-METHYL-L-VALINE
CBNumber
CB1401257
Molecular Formula
C11H21NO4
Formula Weight
231.29
MOL File
45170-31-8.mol
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Boc-N-Me-Val-OH Property

Melting point:
45-60°C
Boiling point:
322.4±21.0 °C(Predicted)
alpha 
-94 º (c=0.5% in ethanol)
Density 
1.069±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly)
form 
Solid
pka
4.03±0.10(Predicted)
color 
Off-White
optical activity
[α]20/D 94±3°, c = 0.5% in ethanol
BRN 
2646180
InChI
InChI=1S/C11H21NO4/c1-7(2)8(9(13)14)12(6)10(15)16-11(3,4)5/h7-8H,1-6H3,(H,13,14)/t8-/m0/s1
InChIKey
XPUAXAVJMJDPDH-QMMMGPOBSA-N
SMILES
C(O)(=O)[C@H](C(C)C)N(C(OC(C)(C)C)=O)C
CAS DataBase Reference
45170-31-8(CAS DataBase Reference)
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Safety

WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29225090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.53085
Product name
Boc-N-Me-Val-OH
Purity
Novabiochem?
Packaging
5G
Price
$135
Updated
2024/03/01
Sigma-Aldrich
Product number
15538
Product name
Boc-N-Me-Val-OH
Purity
≥99.0% (TLC)
Packaging
1g
Price
$39.44
Updated
2024/03/01
Alfa Aesar
Product number
H62771
Product name
N-Boc-N-methyl-L-valine, 95%
Packaging
1g
Price
$68.65
Updated
2024/03/01
Alfa Aesar
Product number
H62771
Product name
N-Boc-N-methyl-L-valine, 95%
Packaging
5g
Price
$292.65
Updated
2024/03/01
Usbiological
Product number
264718
Product name
Boc-N-methyl-L-valine
Packaging
500mg
Price
$333
Updated
2021/12/16
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Boc-N-Me-Val-OH Chemical Properties,Usage,Production

Chemical Properties

White powder

Uses

N-Boc-N-methyl-L-valine (Boc-N-Me-Val-OH) is an amino acid derived compound that functions as a useful pharmaceutical intermediate and also employed as a reagent used in organic synthesis. It is used in the synthesis of lactam analog of actinomycin D, a potential antitumor chemotherapeutic agent. It is also used to N-tert-Butoxycarbonyl-N-methyl-L-valine 4-ethynylanilide with 4-ethynylaniline[1].

Synthesis

To a solution of N-BOC-valine 1 (217 mg, 1 mmol) and iodomethane(1.42 g, 10 mmol) in anhydrous tetrahydrofuran (THF,20 mL) was added neat sodium hydride (240 mg, 10 mmol). The reaction mixture was stirred at room temperature for 24 hours. The mixture was then quenched with water (30 mL). The reaction mixture was extracted with ethyl acetate (EtOAc, 2 15 mL) and the aqueous solution was acidified to pH 3, after which it was extracted with EtOAc (3 20 mL). The combined organic phase was dried over anhydrous Na2SO4 and evaporated to afford the corresponding Boc-N-Me-Val-OH (thick colorless oil), 99% yield.

References

[1] Masashi Shiotsuki. “Molecular weight dependence of helical conformation of amino acid-based polyphenylacetylenes.” Journal of Polymer Science Part A: Polymer Chemistry 49 22 (2011): 4921–4925.

Boc-N-Me-Val-OH Preparation Products And Raw materials

Raw materials

Preparation Products

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Boc-N-Me-Val-OH Suppliers

China 204 Europe 1 France 1 Germany 6 India 8 Japan 4 Switzerland 4 United Kingdom 9 United States 38 Global 275
ChemPep, Inc.
Tel
+1 (888) 615-9178 / (561) 791-8787
Fax
+1 (561) 791-8728
Email
service@chempep.com
Country
United States
ProdList
2138
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57
HBCChem, Inc.
Tel
+1-510-219-6317
Fax
+1-650-486-1361
Email
sales@hbcchem.com
Country
United States
ProdList
10658
Advantage
60
Alabiotech Inc.
Tel
001-619-354-5251
Fax
001-855-855-6087
Email
sales@alabiotech-e.com
Country
United States
ProdList
972
Advantage
60
AbaChemScene
Tel
732-484-9848
Fax
888-484-5008
Email
sales@chemscene.com
Country
United States
ProdList
3986
Advantage
60
BOC Sciences
Tel
16314854226; +16314854226
Email
inquiry@bocsci.com
Country
United States
ProdList
19743
Advantage
58
Accela ChemBio Inc.
Tel
(+1)-858-699-3322
Fax
(+1)-858-876-1948
Email
info@accelachem.com
Country
United States
ProdList
19965
Advantage
58
Alchem Pharmtech,Inc.
Tel
8485655694
Email
sales@alchempharmtech.com
Country
United States
ProdList
63711
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57511
Advantage
58
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View Lastest Price from Boc-N-Me-Val-OH manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd
Product
Boc-N-Me-Val-OH 45170-31-8
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1T+
Release date
2023-09-27
Shanghai Getian Industrial Co., LTD
Product
Boc-N-Me-Val-OH 45170-31-8
Price
US $28.00/box
Min. Order
1box
Purity
99%
Supply Ability
20000box
Release date
2024-06-03
Zibo Hangyu Biotechnology Development Co., Ltd
Product
Boc-N-Me-Val-OH 45170-31-8
Price
US $65.00-650.00/KG
Min. Order
1KG
Purity
0.99
Supply Ability
20 tons
Release date
2023-10-25

45170-31-8, Boc-N-Me-Val-OHRelated Search:

Thiophanate-methyl Methylparaben Bensulfuron methyl N-Carbobenzyloxyglycine Kresoxim-methyl Boc-Aib-OH Sodium carboxymethyl cellulose N-Methyl-2-pyrrolidone 1-Methylimidazole 1-Methylpyrrolidine L-Valine Methyl acrylate N,N-Dimethylformamide PYRAZOPHOS N-Boc-L-valine Valine CARBONYL SULFIDE Methyl

  • BOC-N-METHYL-L-VAL-OH
  • Boc-N-me-Val
  • N-ALPHA-TERT-BUTYLOXYCABONYL-N-ALPHA-METHYL-L-VALINE
  • NALPHA-tert-Butoxycarbonyl-N-methyl-L-valine
  • N-[(tert-Butoxy)carbonyl]-N-methyl-L-valine
  • Boc-L-N-Me-Val-OH
  • (S)-2-((tert-Butoxycarbonyl)(Methyl)aMino)-3-Methylbutanoic acid
  • Boc-N-Me-Val-OH >=99.0% (TLC)
  • Boc-N-Me-L-Val-OH
  • (2S)-2-[[(tert-Butoxy)carbonyl](methyl)amino]-3-methylbutanoic acid
  • BOC-N-METHYL-L-VALINE
  • BOC-N-ME-VALINE
  • BOC-N-ME-VAL-OH
  • BOC-MEVAL-OH
  • BOC-N-ALPHA-METHYL-L-VALINE
  • BOC-L-MEVAL-OH
  • N-ALPHA-T-BOC-N-ALPHA-METHYL-L-VALINE
  • N-ALPHA-T-BUTOXYCARBONYL-N-ALPHA-METHYL-L-VALINE
  • N-ALPHA-T-BUTYLOXYCARBONYL-N-ALPHA-METHYL-L-VALINE
  • N-ALPHA-TERT-BUTYLOXYCARBONYL-N-ALPHA-METHYL-L-VALINE
  • N-BOC-N-METHYL-(L)-VALINE
  • Boc-N-methyl-L-valine≥ 99% (TLC)
  • (Tert-Butoxy)Carbonyl N-Me-Val-OH (Syrup)
  • N-(tert-Butoxycarbonyl)-N-methyl-L-valine&gt
  • (S)-2-((tert-ButoxycarbonyL
  • )amino)-3-methyL
  • L-Valine, N-[(1,1-dimethylethoxy)carbonyl]-N-methyl-
  • (2S)-3-methyl-2-[methyl-[(2-methylpropan-2-yl)oxycarbonyl]amino]butanoicaci
  • Boc-N-methyl-L-valine USP/EP/BP
  • N-Boc-N-methylvaline
  • Boc-N-α-Methyl-L-valine
  • Entecavir Impurity 133
  • 45170-31-8
  • N-Methyl Amino Acids
  • Peptide Synthesis
  • Unnatural Amino Acid Derivatives
  • Specialty Synthesis
  • amino acids
  • Valine [Val, V]
  • N-Methyl Amino Acids
  • Boc-Amino acid series