6-Aminopenicillanic acid

ChemicalBook > CAS DataBase List > 6-Aminopenicillanic acid

6-Aminopenicillanic acid

Product Name: 6-Aminopenicillanic acid
CAS No.: 551-16-6
Chemical Name: 6-Aminopenicillanic acid
Synonyms: 6-APA;6-amino penicillanic acid(6-APA);6-Amino;Flucloxacillin EP Impurity C;AMoxicillin Related CoMpound A;6-AMINO-2,2-DIMETHYL-5-OXOPERHYDROAZETO[2,1-B][1,3]THIAZOLE-3-CARBOXYLIC ACID;Amoxicillin Related Compound A (15 mg) ((2S,5R,6R)-6-Amino-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid);penin;6-aps;penicin
CBNumber: CB1410046
Molecular Formula: C8H12N2O3S
Formula Weight: 216.26
MOL File: 551-16-6.mol

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6-Aminopenicillanic acid Property

Melting point:: 198-200 °C (dec.)(lit.)
alpha: 276.3 º (c=1.2, 0.1N HCl 22 ºC)
Boiling point:: 460.2±45.0 °C(Predicted)
Density: 1.3418 (rough estimate)
refractive index: 1.6300 (estimate)
storage temp.: 2-8°C
solubility: 2.46g/l
pka: pKa 2.3 (Uncertain)
form: Fine Powder
color: White to cream
PH: 3.4 (100g/l, H2O)
optical activity: [α]22/D +276.3°, c = 1.2 in 0.1 M HCl
Water Solubility: Soluble in water and hydrochoric acid.
Merck: 14,458
BRN: 15080
Stability:: Light sensitive
InChIKey: NGHVIOIJCVXTGV-SDKNWNMFSA-N
LogP: -3.87 at 22.5℃
CAS DataBase Reference: 551-16-6(CAS DataBase Reference)
EPA Substance Registry System: 6-Aminopenicillanic acid (551-16-6)

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Safety

Hazard Codes: Xn
Risk Statements: 42/43
Safety Statements: 22-36/37-45-37-24-36
WGK Germany: 2
RTECS: XH8225000
F: 10
TSCA: Yes
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHR2188
Product name: Amoxicillin Related Compound A
Packaging: 50MG
Price: $534
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1031514
Product name: Amoxicillin Related Compound A
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 15mg
Price: $1490
Updated: 2024/03/01

Sigma-Aldrich

Product number: 07307
Product name: (+)-6-Aminopenicillanic acid
Purity: analytical standard
Packaging: 100mg
Price: $80.4
Updated: 2024/03/01

TCI Chemical

Product number: A0800
Product name: 6-Aminopenicillanic Acid
Purity: >98.0%(HPLC)
Packaging: 5g
Price: $18
Updated: 2024/03/01

TCI Chemical

Product number: A0800
Product name: 6-Aminopenicillanic Acid
Purity: >98.0%(HPLC)
Packaging: 25g
Price: $53
Updated: 2024/03/01

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6-Aminopenicillanic acid Chemical Properties,Usage,Production

Chemical Properties

WHITE TO CREAM FINE POWDER

Uses

(+)-6-Aminopenicillanic Acid is the core structure in penicillins, obtained from the fermentation brew of the Penicillium mold. (+)-6-Aminopenicillanic Acid is used as the main starting block for the preparation of numerous semisynthetic penicillins.

Uses

6-Aminopenicillanic acid is the basic unit in penicillin?s, which is obtained from the fermentation brew of the Penicillium mold. It acts as a starting material for the preparation of many semisynthetic penicillins. Further, it serves as apharmaceutical intermediate. In addition to this, it is used in antibiotics research and experimental application.

Definition

ChEBI: A penicillanic acid compound having a (6R)-amino substituent. The active nucleus common to all penicillins, it may be substituted at the 6-amino position to form the semisynthetic penicillins, resulting in a variety of antibacterial and ph rmacologic characteristics.

General Description

Chemical structure: ?-lactam

Flammability and Explosibility

Non flammable

Safety Profile

Questionable carcinogen with experimental tumorigenic data. When heated to decomposition it emits very toxic fumes of NOx and SOx.

Purification Methods

This acid crystallises from water. [Kleppe & Stroninger J Biol Chem 254 4856 1979,Beilstein 27 III/IV 2858.]

6-Aminopenicillanic acid Preparation Products And Raw materials

Raw materials

Ampicillin Bis(2-dimethylaminoethyl) ether Imine Penicillin G potassium salt Ampicillin Ammonium bicarbonate

Preparation Products

Piperacillin CARBENICILLIN Penicillin G Imipenem Oxacillin sodium monohydrate

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View Lastest Price from 6-Aminopenicillanic acid manufacturers

Guangzhou PI PI BIOTECH INC

Product: Piperacillin Impurity H(EP) 551-16-6
Price: US $0.00-0.00/mg
Min. Order: 10mg
Purity: 90%+
Supply Ability: 500mg
Release date: 2021-05-15

airuikechemical co., ltd.

Product: Aminopenicillanic Acid 551-16-6
Price: US $0.00-0.00/Kg
Min. Order: 1Kg
Purity: 99.9%
Supply Ability: 200tons
Release date: 2024-04-09

Hebei Duling International Trade Co. LTD

Product: (+)-6-Aminopenicillanic acid 551-16-6
Price: US $20.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000 tons
Release date: 2022-09-15

551-16-6, 6-Aminopenicillanic acidRelated Search:

Dimethyl ether Dimethyl fumarate ETHANE EC 2.6.1.2 6-Aminocaproic acid Acetaminophen Dimethyl sulfoxide 2-(2-Aminothiazol-4-yl)glyoxylic acid N,N-Dimethyl-1,4-phenylenediamine N,N-Dimethylformamide Dicloxacillin sodium Heptane Glucosamine Ethyl 2-(Chlorosulfonyl)acetate 12-AMINODODECANOIC ACID Dimethyl carbonate Sodium 1-heptanesulfonate Methyl 6-aminonicotinate

6-AMINO-2,2-DIMETHYL-5-OXOPERHYDROAZETO[2,1-B][1,3]THIAZOLE-3-CARBOXYLIC ACID

6-AMINO-3,3-DIMETHYL-7-OXO-4-THIA-1-AZABICYCLO[3.2.0]HEPTANE-2-CARBOXYLIC ACID

6-APA

(+)-6-AMINOPENICILLANIC ACID

6-AMINOPENICILLANIC ACID

6-AMINO PENICILLINIC ACID

7-AMINO-3,3-DIMETHYL-6-OXO-2-THIA-5-AZABICYCLO[3.2.0]HEPTANE-4-CARBOXYLIC ACID

(25,5R,6R)-6-AMINO-3,3-DIMETHYL-7-OXO-4-THIA-1-AZABICYCLO[3.2.0]HEPTANE-2-CARBOXYLIC ACID

(2S,5R,6R)-6-AMINO-3,3-DIMETHYL-7-OXO-4-THIA-1-AZABICYCLO-[3.2.0]HEPTANE-2-CARBOXYLIC ACID

aminopenicillanicacid

penicin

penin

phenacyl6-aminopenicillinate

4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-amino-3,3-dimethyl-7-oxo-, [2S-(2alpha,5alpha,6beta)]-

6-Aminopenicillanic acid;6-Amino-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; 6-APA

6-amino penicillanic acid(6-APA)

6-Aminopenicillanicacid,98%

6-Amino

6-Amino-2,2-dimethyl-5-oxoperhydroazeto[2,1-b][1,3]thiazole-3-carboxylic acid 98%

6-Aminopenicillansure

4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid,6-amino-3,3-dimethyl-7-oxo-,[2S-(2.alpha.,5.alpha.,6.beta.)]

6-AMINOPENICILLANIC ACID 99%

(2S,5R,6R)-6-Amino-2,2-dimethyl-5-oxoperhydroazeto[2,1-b][1,3]thiazole-3-carboxylic acid 98%

(2S,5R,6R)-6-Amino-2,2-dimethyl-5-oxoperhydroazeto[2,1-b][1,3]thiazole-3-carboxylic acid

AMoxicillin IMpurity A (SulbactaM IMpurity B)

Piperacillin IMpurity H

Amoxicillin EP Impurity A

(+)-6-Aminopenicillanic acid, >=99.0%

Penicillan intermediate: penicillan core

6-Aminopenicillanic acid for synthesis

Amoxicillin EP Impurity A(Sulbactam EP Impurity B)

(2S,5R,6R)-6-Amino-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 6-APA 6-Amino-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 6-amino-2,2-dimethyl-5-oxoperhydroazeto[2,1-b][1

Sulbactam impurity B

6-aminopenicilanic acid(6-APA)

Cloxacillin Impurity 3(Cloxacillin EP Impurity C)

Dicloxacillin Impurity 3(Dicloxacillin EP Impurity C)

Flucloxacillin Impurity 3(Flucloxacillin EP Impurity C)

Piperacillin Impurity 8(EP Impurity H)

Sulbactam Impurity 2(Sulbactam EP Impurity B)

Ampicillin Impurity 1（Ampicillin EP Impurity A）

Piperacillin Sodium EP Impurity H

Phenoxymethylpenicillin Impurity 3（Phenoxymethylpenicillin EP Impurity C）

Amoxicillin Impurity 1（EP Impurity A）

(2S,5R,6R)-(+)-6-Amino-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 97%

Benzylpenicillin Impurity 1（Benzylpenicillin EP Impurity A)

4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid,6-amino-3,3-dimethyl-7-oxo

5alpha,6beta)]-[2s-(2alpha

6-amino-3,3-dimethyl-7-oxo-,[2S-(2.alpha.,5.alpha.,6.beta.)]-4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid

6-aps

6-APA, (2S,5R,6R)-6-Amino-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-amino-3,3-dimethyl-7-oxo-, (2S,5R,6R)-

(2S,5β)-6α-Amino-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2β-carboxylic acid

(2β,5β)-6α-Amino-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2β-carboxylic acid

(6R)-6-Aminopenicillanic acid

6-Aminopenicillanic acid,96%

6-AMinopenicillanic acid, 96% 25GR

[2S-(2α,5α,6β)]-6-AMino-3,3-diMethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid

NSC 50071