1-Bromo-4-(trifluoromethoxy)benzene

Product Name: 1-Bromo-4-(trifluoromethoxy)benzene
CAS No.: 407-14-7
Chemical Name: 1-Bromo-4-(trifluoromethoxy)benzene
Synonyms: 4-Bromozbenzotrifluoride;P-BROMOTRIFLUOROMETHOXYBENZENE;4-(TRIFLUOROMETHOXY)BROMOBENZENE;1-Bromo-4-(trifL;TIMTEC-BB SBB006606;1-Bromo-4-(trifluoro;Benzene, 1-bromo-4-(trifluo;P-Bromotrifluoromethoxybenzen;1-Bromo-4-(Trifluoromethoxy)Be;P-TRIFLUOROMETHOXY BROMOBENZENE
CBNumber: CB1413764
Molecular Formula: C7H4BrF3O
Formula Weight: 241.01
MOL File: 407-14-7.mol

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1-Bromo-4-(trifluoromethoxy)benzene Property

Boiling point:: 80 °C50 mm Hg(lit.)
Density: 1.622 g/mL at 25 °C(lit.)
vapor pressure: 20 hPa (55 °C)
refractive index: n20/D 1.461(lit.)
Flash point:: 154 °F
storage temp.: Sealed in dry,Room Temperature
solubility: 11.7mg/l
form: Liquid
Specific Gravity: 1.64
color: Clear colorless to yellow
Water Solubility: 11.7mg/L
BRN: 2046332
InChI: InChI=1S/C7H4BrF3O/c8-5-1-3-6(4-2-5)12-7(9,10)11/h1-4H
InChIKey: SEAOBYFQWJFORM-UHFFFAOYSA-N
SMILES: C1(Br)=CC=C(OC(F)(F)F)C=C1
CAS DataBase Reference: 407-14-7(CAS DataBase Reference)
NIST Chemistry Reference: P-bromophenyl trifluoromethyl ether(407-14-7)

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Safety

Hazard Codes: Xn,N,Xi
Risk Statements: 22-36/37/38-43-51/53
Safety Statements: 26-36/37-61-37/39-36
RIDADR: UN 3082 9/PG 3
WGK Germany: 1
HazardClass: IRRITANT
HS Code: 29093090
Toxicity: LD50 orally in Rabbit: > 2500 mg/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 339601
Product name: 1-Bromo-4-(trifluoromethoxy)benzene
Purity: 99%
Packaging: 5g
Price: $25.46
Updated: 2025/07/31

Sigma-Aldrich

Product number: 8.14964
Product name: 1-Bromo-4-(trifluoromethoxy)benzene
Purity: for synthesis
Packaging: 50mL
Price: $184
Updated: 2023/01/07

TCI Chemical

Product number: B1772
Product name: 1-Bromo-4-(trifluoromethoxy)benzene
Purity: >98.0%(GC)
Packaging: 5g
Price: $20
Updated: 2025/07/31

TCI Chemical

Product number: B1772
Product name: 1-Bromo-4-(trifluoromethoxy)benzene
Purity: >98.0%(GC)
Packaging: 25g
Price: $49
Updated: 2025/07/31

TRC

Product number: B695178
Product name: 1-Bromo-4-(trifluoromethoxy)benzene
Packaging: 1g
Price: $55
Updated: 2021/12/16

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1-Bromo-4-(trifluoromethoxy)benzene Chemical Properties,Usage,Production

Chemical Properties

CLEAR COLOURLESS TO YELLOW LIQUID

Uses

1-Bromo-4-(trifluoromethoxy)benzene was used in the synthesis of 4-{[4-[(2-ethylhexyloxy)-6-(4-morpholinylmethyl)-4-trifluoromethyl][1,1-biphenyl]-3-yl]methyl}morpholine.

Synthesis Reference(s)

Journal of the American Chemical Society, 109, p. 3708, 1987 DOI: 10.1021/ja00246a030

General Description

1-Bromo-4-(trifluoromethoxy)benzene on treatment with lithium diisopropylamide (LIDA) at -100°C gives 5-bromo-2-(trifluoromethoxy)phenyllithium and at -75°C it eliminates lithium bromide, thus generating 1,2-dehydro-4-(trifluoromethoxy)benzene.

Synthesis

143582-87-0

407-14-7

GENERAL METHOD: To a solution of dichloroethane (2 mL) containing IF5-pyridine-HF (321 mg, 1.0 mmol), Et3N-6HF (553 mg, 2.5 mmol) and 2a (113 mg, 0.5 mmol) were sequentially added at room temperature. The reaction mixture was stirred at 60 °C for 9 hours. Upon completion of the reaction, the dark red solution was poured into water (20 mL) and extracted with dichloromethane (20 mL x 3). The organic layers were combined, washed sequentially with aqueous NaHCO3 and aqueous Na2S2O3, and dried over MgSO4. The yield of 4a was determined to be 74% by 19F NMR using fluorobenzene as an internal standard. Purification by column chromatography (silica gel/hexane) afforded 4a. IR (pure) 2963, 1256, 1212 cm-1; 1H NMR δ 7.23 (d, J = 8.8 Hz, 2H), 7.13 (d, J = 8.4 Hz, 2H), 2.95-2.85 (m, 1H), 1.24 (d, J = 6.8 Hz, 6H); 19F NMR δ -58.53 (s, 3F); 13C NMR δ 147.7, 147.3, 127.8 (2C), 121.0 (2C), 120.7 (q, 1JC-F = 257.7 Hz), 33.7, 24.1 (2C); HRMS (EI) calculated value C10H11F3O 204.07620, measured value 204.07606.

References

[1] Tetrahedron Letters, 1992, vol. 33, # 29, p. 4173 - 4176
[2] Bulletin of the Chemical Society of Japan, 2000, vol. 73, # 2, p. 471 - 484
[3] Journal of Fluorine Chemistry, 2015, vol. 179, p. 48 - 52
[4] Patent: US2015/315136, 2015, A1. Location in patent: Paragraph 0132; 0137; 0138

1-Bromo-4-(trifluoromethoxy)benzene Preparation Products And Raw materials

Raw materials

Bromobenzene

Preparation Products

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View Lastest Price from 1-Bromo-4-(trifluoromethoxy)benzene manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 1-Bromo-4-(trifluoromethoxy)benzene 407-14-7
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 mt
Release date: 2024-12-04

Henan Aochuang Chemical Co.,Ltd.

Product: 1-Bromo-4-(trifluoromethoxy)benzene 407-14-7
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-08

Shaanxi Dideu New Materials Co. Ltd

Product: 1-Bromo-4-(trifluoromethoxy)benzene 407-14-7
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-02-22

407-14-7, 1-Bromo-4-(trifluoromethoxy)benzeneRelated Search:

4-(Trifluoromethoxy)aniline o-Anisaldehyde 4-Methoxybenzyl cyanide 4-(Trifluoromethoxy)benzaldehyde 3-(Trifluoromethoxy)aniline Xylene 2-(Trifluoromethoxy)aniline p-Anisaldehyde m-Anisyl alcohol 4-(Trifluoromethoxy)chlorobenzene 4-Methoxybenzoic acid p-Trifluoromethoxy phenol 4'-(Trifluoromethoxy)acetophenone 3-Methoxybenzaldehyde Anisole 4-Methoxyphenylacetic acid (Trifluoromethoxy)benzene Benzene

4-BROMO-ALPHA,ALPHA,ALPHA-TRIFLUOROANISOLE

4-BROMO(TRIFLUOROMETHOXY)BENZENE

4-(TRIFLUOROMETHOXY)BROMOBENZENE

TIMTEC-BB SBB006606

P-TRIFLUOROMETHOXY BROMOBENZENE

P-BROMOTRIFLUOROMETHOXYBENZENE

Benzene, 1-bromo-4-(trifluoromethoxy)-

1-BROMO-4-(TRIFLUOROMETHOXY)BENZENE

P-Bromotrifluoromethoxybenzen

4-Bromozbenzotrifluoride

1-Bromo-4-(Trifluoromethoxy)Be

4-(Trifluoromethoxy)bromobenzene 99%

4-BROMOA-TRIFLUOROMETHOXYBENZENE

4-(Trifluoromethoxy)bromobenzene99%

4-(trifluoromethoxy)bromobenzene,1-bromo-4-(trifluoromethoxy)benzene

1-Brom-4-(trifluormethoxy)benzol

1-Bromo-4-(trifluromethoxy)benzene

p-Bromophenyl trifluoromethyl ether

4-Bromophenyl(trifluoromethyl) ether

1-Bromo-4-(trifluoromethoxy)benzene,98%

Benzene, 1-bromo-4-(trifluo

1-Bromo-4-(trifluoro

BroMo (trifluoroMethoxy) benzene

4-Bromo-alpha,alpha,alpha-trifluoroanisole 4-(Trifluoromethoxy)bromobenzene

1-BROMO-4-(TRIFLUOROMETHOXY)BENZENE FOR

1-Bromo-4-(trifluoromethoxy)benzene 98%

4-Bromophenyl trifluoromethyl ether, 4-Bromo-alpha,alpha,alpha-trifluoroanisole

1-BroMo-4-(trifluoroMethoxy)benzene, 97+%

For trifluoromethoxybromobenzene

The broMine trifluoro Methoxy benzene

4-BroMo-1-(trifluoroMethoxy)benzene

4-(trifluoromrthoxy)bromobenzene

1-Bromo-4-(Trifluoromethyoxy)Benzene

1-Bromo-4-(trifL

1-Bromo-4-(trifluoromethoxy)benzene &gt

1-Bromo-4-(trifluoromethoxy)benzene D4

407-14-7

C7H4BrOF3

BrC6H4OCF3

Building Blocks for Liquid Crystals

Chalcones, etc. (Building Blocks for Liquid Crystals)

Ethers

Organic Building Blocks

Oxygen Compounds

Building Blocks

Ethers

Organic Building Blocks

Oxygen Compounds

Fluorobenzene

Aromatic Halides (substituted)

Trifluoromethoxybenzene Series

Miscellaneous

Anisoles, Alkyloxy Compounds & Phenylacetates

Bromine Compounds

Fluorine Compounds

Building Blocks for Liquid Crystals

Chalcones, etc. (Building Blocks for Liquid Crystals)

Functional Materials