ChemicalBook > CAS DataBase List > 6-AZAURIDINE

6-AZAURIDINE

Product Name
6-AZAURIDINE
CAS No.
54-25-1
Chemical Name
6-AZAURIDINE
Synonyms
azauridine;6-azuridine;azur;6-azur;nsc32074;AZURIDINE;Aids008706;Aids-008706;6-AZAURIDINE;ribo-azuracil
CBNumber
CB1413830
Molecular Formula
C8H11N3O6
Formula Weight
245.19
MOL File
54-25-1.mol
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6-AZAURIDINE Property

Melting point:
157-159 °C(lit.)
Boiling point:
388.15°C (rough estimate)
Density 
1.4866 (rough estimate)
refractive index 
1.7950 (estimate)
storage temp. 
2-8°C
solubility 
DMSO (Slightly, Heated), Methanol (Slightly, Heated), Pyridine (Slightly), Water
form 
Powder
pka
6.70(at 25℃)
color 
White
Water Solubility 
It is soluble in water.
Merck 
14,904
Stability:
Hygroscopic
InChIKey
WYXSYVWAUAUWLD-YGWZKZRUSA-N
CAS DataBase Reference
54-25-1(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
20/21/22-40
Safety Statements 
22-36
WGK Germany 
3
RTECS 
XY8575000
HS Code 
29349990
Hazardous Substances Data
54-25-1(Hazardous Substances Data)
Toxicity
LD50 oral in quail: > 316mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H351Suspected of causing cancer

Precautionary statements

P201Obtain special instructions before use.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A1882
Product name
6-Azauridine
Packaging
1g
Price
$86.1
Updated
2024/03/01
Sigma-Aldrich
Product number
A1882
Product name
6-Azauridine
Packaging
5g
Price
$481
Updated
2024/03/01
TCI Chemical
Product number
A0559
Product name
6-Azauridine
Purity
>99.0%(HPLC)
Packaging
10mg
Price
$30
Updated
2024/03/01
Alfa Aesar
Product number
J61309
Product name
6-Azauridine
Packaging
1g
Price
$118.65
Updated
2024/03/01
Alfa Aesar
Product number
J61309
Product name
6-Azauridine
Packaging
5g
Price
$471.65
Updated
2024/03/01
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6-AZAURIDINE Chemical Properties,Usage,Production

Chemical Properties

White powder

Uses

6-Azauridine can be applied in antiviral studies. 6-azauridine inhibits de novo pyrimidine synthesis and DNA synthesis and is converted intracellularly into mono, di, and triphosphate derivatives, which incorporate into RNA and inhibit protein synthesis. It is also used as an antineoplastic antimetabolite. It interferes with pyrimidine biosynthesis thereby preventing formation of cellular nucleic acids. As the triacetate, it is also effective as an antipsoriatic.

Uses

6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP and it is used in antiviral studies.

Uses

Research on cell formation and cancer.

Definition

ChEBI: 6-azauridine is a N-glycosyl-1,2,4-triazine. It has a role as an antineoplastic agent, an antimetabolite and a drug metabolite.

General Description

6-Azauridine is a pyrimidine nucleoside analog.

Biochem/physiol Actions

6-azauridine is a prodrug, upon conversion to 6-aza-UMP, inhibits uridine monophosphate synthase (UMPS). It is a broad spectrum anti-metabolite. It interferes with pyrimidine biosynthesis and affects the cellular nucleic acid levels. It is considered as a antineoplastic metabolite. It inhibits RNA viruses like chikungunya virus, semliki forest virus, and human coronavirus. It significantly inhibits the growth of Cryptosporidium parasites.

6-AZAURIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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6-AZAURIDINE Suppliers

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Panaishen (Henan) Pharmaceutical Science and Technology Co. , Ltd.
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View Lastest Price from 6-AZAURIDINE manufacturers

Career Henan Chemical Co
Product
6-AZAURIDINE 54-25-1
Price
US $1.00/kg
Min. Order
1kg
Purity
95%-99%
Supply Ability
as request
Release date
2018-12-24
Career Henan Chemical Co
Product
6-AZAURIDINE 54-25-1
Price
US $1.00/kg
Min. Order
1kg
Purity
95%-99%
Supply Ability
100kg
Release date
2018-12-24

54-25-1, 6-AZAURIDINERelated Search:

6-AZAURIDINE 2',3',5'-TRIACETATE Semicarbazide 2-Hydroxyethylhydrazine (Hydroxymethyl)urea 2-HYDROXYETHYLUREA 6-AZAURIDINE 3-Methylamino-1,2-propanediol 1,3-DIETHYLUREA 6-AZAURACIL N-Butylurea 6-Azauracil 6-AZA-2'-DEOXYURIDINE 6-AZAURIDINE-5'-MONOPHOSPHATE,6-Azauridine 5'-phosphoric acid N-ETHYL-N-FORMYLHYDRAZINE 5-Methyl-2'-deoxy-6-azauridine 2-THIO-6-AZAURIDINE 6-azauridine 5'-triphosphate 5-Azauridine

  • 6-AZA-2,4-DIHYDROXYPYRIMIDINE RIBOSIDE
  • 6-AZAURIDINE MONOHYDRATE
  • 6-AZAURACIL RIBOSIDE
  • 6-AZAURACIL RIBOSIDE MONOHYDRATE
  • 6-AZAURIDINE
  • 2-BETA-D-RIBOFURANOSYL-1,2,4-TRIAZINE-3,5(2H,4H)-DIONE
  • AZAURIDINE, 6-
  • 2-beta-d-ribofuranosyl-1,2,4-triazin-3,5(2h,4h)-dion
  • 2-beta-d-ribofuranosyl-as-triazine-3,5(2h,4h)-dione
  • 3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazineriboside
  • 4h)-dione,2-beta-d-ribofuranosyl-as-triazine-5(2h
  • 4-triazine-3,5(2h,4h)-dione,2-beta-d-ribofuranosyl-2
  • 6-azauracil1-riboside
  • 6-azauracil-beta-d-riboside
  • 6-azauracilribosid
  • 6-azur
  • 6-azuridine
  • azauridine
  • azur
  • nsc32074
  • ribo-azuracil
  • 2-(beta-D-ribofuranosyl)-1,2,4-triazine-3,5-diol
  • 2-β-d-ribofuranosyl-1,2,4-triazine-3,5(2h,4h)-dione
  • AZURIDINE
  • TRIAZINE-3,5-DIONE,2-BETA-D-RIBOFURANOSYL-
  • 6-Azauracil riboside, 2-β-D-Ribofuranosyl-1,2,4-triazine-3,5(2H,4H)-dione
  • Ribo-Azauracil
  • 1,2,4-Triazine-3,5(2H,4H)-dione, 2-.beta.-D-ribofuranosyl-
  • Aids008706
  • Aids-008706
  • 2-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxyMethyl)tetrahydrofuran-2-yl)-1,2,4-triazine-3,5(2H,4H)-dione
  • 1,2,4-Triazine-3,5(2H,4H)-dione,2-b-D-ribofuranosyl-
  • Rib-Azauracil
  • 6-AZAURIDINE CRYSTALLINE
  • 6-Azauridine&gt
  • 1,2,4-Triazine-3,5(2H,4H)-dione, 2-β-D-ribofuranosyl-
  • 6-AZAURIDINE USP/EP/BP
  • 6-Azauridine, antimetabolic antineoplastic agent
  • 1-(beta-D-Ribofuranosyl)-6-azauracil
  • 54-25-1
  • C8H11N3O6H2O
  • C8H11N3O6
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