6-AZAURIDINE Property

Melting point:

157-159 °C(lit.)

Boiling point:

388.15°C (rough estimate)

Density 

1.4866 (rough estimate)

refractive index 

1.7950 (estimate)

storage temp. 

2-8°C

solubility 

DMSO (Slightly, Heated), Methanol (Slightly, Heated), Pyridine (Slightly), Water

form 

Powder

pka

6.70(at 25℃)

color 

White

Water Solubility 

It is soluble in water.

Merck 

14,904

Stability:

Hygroscopic

InChIKey

WYXSYVWAUAUWLD-YGWZKZRUSA-N

CAS DataBase Reference

54-25-1(CAS DataBase Reference)

Safety

Hazard Codes 

Xn

Risk Statements 

20/21/22-40

Safety Statements 

22-36

WGK Germany 

3

RTECS 

XY8575000

HS Code 

29349990

Hazardous Substances Data

54-25-1(Hazardous Substances Data)

Toxicity

LD50 oral in quail: > 316mg/kg

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H351Suspected of causing cancer

Precautionary statements

P201Obtain special instructions before use.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P308+P313IF exposed or concerned: Get medical advice/attention.

6-AZAURIDINE Chemical Properties,Usage,Production

Chemical Properties

White powder

Uses

6-Azauridine can be applied in antiviral studies. 6-azauridine inhibits de novo pyrimidine synthesis and DNA synthesis and is converted intracellularly into mono, di, and triphosphate derivatives, which incorporate into RNA and inhibit protein synthesis. It is also used as an antineoplastic antimetabolite. It interferes with pyrimidine biosynthesis thereby preventing formation of cellular nucleic acids. As the triacetate, it is also effective as an antipsoriatic.

Uses

6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP and it is used in antiviral studies.

Uses

Research on cell formation and cancer.

Definition

ChEBI: 6-azauridine is a N-glycosyl-1,2,4-triazine. It has a role as an antineoplastic agent, an antimetabolite and a drug metabolite.

General Description

6-Azauridine is a pyrimidine nucleoside analog.

Biochem/physiol Actions

6-azauridine is a prodrug, upon conversion to 6-aza-UMP, inhibits uridine monophosphate synthase (UMPS). It is a broad spectrum anti-metabolite. It interferes with pyrimidine biosynthesis and affects the cellular nucleic acid levels. It is considered as a antineoplastic metabolite. It inhibits RNA viruses like chikungunya virus, semliki forest virus, and human coronavirus. It significantly inhibits the growth of Cryptosporidium parasites.