ChemicalBook > CAS DataBase List > TERT-BUTYL N,N-BIS(2-HYDROXYETHYL)CARBAMATE

TERT-BUTYL N,N-BIS(2-HYDROXYETHYL)CARBAMATE

Product Name: TERT-BUTYL N,N-BIS(2-HYDROXYETHYL)CARBAMATE
CAS No.: 103898-11-9
Chemical Name: TERT-BUTYL N,N-BIS(2-HYDROXYETHYL)CARBAMATE
Synonyms: tert-Butyl bis(2-hydroxyethyl)carbamate;N-BOC-DIETHANOLAMINE;BOC-DIETHANOLAMINE;1-Boc-diethanolamine;N-Boc-diethanolamine;tert-Butyl bis(2-hydroxyethyl);Boc-diethanolamine≥ 98% (Assay);N-Boc-diethanolamine >=98.0% (GC);Bis(2-hydroxyethyl)amine, N-BOC protected;TERT-BUTYL N,N-BIS(2-HYDROXYETHYL)CARBAMATE
CBNumber: CB1430936
Molecular Formula: C9H19NO4
Formula Weight: 205.25
MOL File: 103898-11-9.mol

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TERT-BUTYL N,N-BIS(2-HYDROXYETHYL)CARBAMATE Property

Boiling point:: 324.2±35.0 °C(Predicted)
Density: 1.085 g/mL at 20 °C(lit.)
refractive index: n20/D 1.461
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 14.29±0.10(Predicted)
form: Liquid or Oil
color: Colorless
BRN: 4386562
InChI: InChI=1S/C9H19NO4/c1-9(2,3)14-8(13)10(4-6-11)5-7-12/h11-12H,4-7H2,1-3H3
InChIKey: KMUNFRBJXIEULW-UHFFFAOYSA-N
SMILES: C(OC(C)(C)C)(=O)N(CCO)CCO
CAS DataBase Reference: 103898-11-9

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
F: 10-21
HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 15268
Product name: N-Boc-diethanolamine
Purity: ≥98.0% (GC)
Packaging: 5ml
Price: $189
Updated: 2023/01/07

Sigma-Aldrich

Product number: 15268
Product name: N-Boc-diethanolamine
Purity: ≥98.0% (GC)
Packaging: 25ml
Price: $538
Updated: 2023/01/07

TRC

Product number: B810020
Product name: tert-Butylbis(2-Hydroxyethyl)carbamate
Packaging: 50mg
Price: $45
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB49770
Product name: Boc-diethanolamine
Packaging: 10g
Price: $200
Updated: 2021/12/16

Synthonix

Product number: B6888
Product name: tert-ButylN,N-bis(2-hydroxyethyl)carbamate
Purity: 97%
Packaging: 100g
Price: $200
Updated: 2021/12/16

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TERT-BUTYL N,N-BIS(2-HYDROXYETHYL)CARBAMATE Chemical Properties,Usage,Production

Description

tert-butyl bis(2-hydroxyethyl)carbamate is a branched PEG with a tert-butyl protecting group and two hydroxyl end groups. The t-butyl group can be deprotected under acidic conditions. The hydroxyl group can react to further derivatize the compound. The hydrophilic PEG linker increases the water solubility of the compound in aqueous media.

Chemical Properties

Light yellow clear liquid

Uses

Building block for the synthesis of cationic lipids, nucleosides, etc.

reaction suitability

reagent type: cross-linking reagent

Synthesis

24424-99-5

111-42-2

103898-11-9

Under nitrogen protection, 2,2'-Azabisethanol (4.21 g, 40 mmol) was dissolved in acetonitrile (50 mL), and a solution of di-tert-butyl dicarbonate (Boc2O, 9.60 g, 44 mmol) in acetonitrile (50 mL) was slowly added. The reaction mixture was stirred at room temperature for 3.5 h. The solvent was removed by concentration under reduced pressure to afford tert-butyl bis(2-hydroxyethyl)carbamate as a colorless oil (8.20 g, 100% yield).

IC 50

Cleavable Linker; Alkyl/ether

References

[1] Bioorganic and Medicinal Chemistry Letters, 1997, vol. 7, # 24, p. 3135 - 3138
[2] Nucleosides and Nucleotides, 1999, vol. 18, # 2, p. 227 - 238
[3] Nucleosides, Nucleotides and Nucleic Acids, 2002, vol. 21, # 2, p. 111 - 123
[4] Bioorganic and Medicinal Chemistry, 2004, vol. 12, # 17, p. 4645 - 4665
[5] Patent: WO2014/12360, 2014, A1. Location in patent: Paragraph 00384

TERT-BUTYL N,N-BIS(2-HYDROXYETHYL)CARBAMATE Preparation Products And Raw materials

Raw materials

Preparation Products

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TERT-BUTYL N,N-BIS(2-HYDROXYETHYL)CARBAMATE Suppliers

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View Lastest Price from TERT-BUTYL N,N-BIS(2-HYDROXYETHYL)CARBAMATE manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: TERT-BUTYL N,N-BIS(2-HYDROXYETHYL)CARBAMATE 103898-11-9
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-05-29

Career Henan Chemical Co

Product: TERT-BUTYL N,N-BIS(2-HYDROXYETHYL)CARBAMATE 103898-11-9
Price: US $1.00/g
Min. Order: 100g
Purity: >98%
Supply Ability: g/kg/Ton
Release date: 2020-01-14

103898-11-9, TERT-BUTYL N,N-BIS(2-HYDROXYETHYL)CARBAMATERelated Search:

N-NITROSODIETHYLAMINE (2R,4R)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate (2R,4R)-N-Boc-4-hydroxypyrrolidine-2-carboxylic acid MORPHOLINE-3,4-DICARBOXYLIC ACID 4-TERT-BUTYL ESTER N-Boc-trans-4-tosyloxy-L-proline methyl ester TERT-BUTYL N,N-BIS(2-HYDROXYETHYL)CARBAMATE N-Boc-trans-4-Hydroxy-L-proline methyl ester Boc-Hyp-OH N-Boc-cis-4-Hydroxy-L-proline methyl ester BOC-HYP(BZL)-OH N-Boc-cis-4-Hydroxy-L-proline BOC-HYP-OL BOC-HYP-OBZL BOC-HYP-OH DCHA BOC-HYP-OTBU BOC-IMINODIACETIC ACID BOC-CISHYP(BZL)-OH 4(R)-T-BUTYLDIMETHYLSILYLOXY-N-BOC-2(S)PROLINOL

TERT-BUTYL N,N-BIS(2-HYDROXYETHYL)CARBAMATE

N-BOC-DIETHANOLAMINE

BOC-DIETHANOLAMINE

Bis(2-hydroxyethyl)amine, N-BOC protected

tert-Butyl bis(2-hydroxyethyl)carbamate

N-Boc-diethanolamine >=98.0% (GC)

1-Boc-diethanolamine

tert-Butyl bis(2-hydroxyethyl)

CarbaMic acid, bis(2-hydroxyethyl)-, 1,1-diMethylethyl ester

Boc-diethanolamine≥ 98% (Assay)

Bis(2-hydroxyethyl)amine, N-BOC protected 97%

Carbamic acid, N,N-bis(2-hydroxyethyl)-, 1,1-dimethylethyl ester

TERT-BUTYL N,N-BIS(2-HYDROXYETHYL)CARBAMATE USP/EP/BP

(t-butoxy)-N,N-bis(2-hydroxyethyl)carboxamide

<i>N</i>-Boc-diethanolamine

tert-Butyl N,N-bis(2-hydroxyethyl)carbamate - [B6888]

103898-11-9

Peptide Synthesis

Linkers

Specialty Synthesis

Trifunctional Crosslinkers