ChemicalBook > CAS DataBase List > 2-Cyanopyrimidine
2-Cyanopyrimidine
- Product Name
- 2-Cyanopyrimidine
- CAS No.
- 14080-23-0
- Chemical Name
- 2-Cyanopyrimidine
- Synonyms
- PYRIMIDINE-2-CARBONITRILE;2-PYRIMIDINECARBONITRILE;2CPM;2-CPY;2-cyanpyrimidine;2-Cynopyrimidine;2-CYANOPYRIMIDINE;Bosentan Impurity 14;Bosentan Impurity 15;2-Cyanopyrimidine >
- CBNumber
- CB1431357
- Molecular Formula
- C5H3N3
- Formula Weight
- 105.1
- MOL File
- 14080-23-0.mol
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2-Cyanopyrimidine Property
- Melting point:
- 40-44 °C (lit.)
- Boiling point:
- 250.7±23.0 °C(Predicted)
- Density
- 1.22±0.1 g/cm3(Predicted)
- Flash point:
- >230 °F
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- soluble in Methanol
- pka
- -3.27±0.13(Predicted)
- form
- Crystalline Powder
- color
- White to yellow
- InChI
- InChI=1S/C5H3N3/c6-4-5-7-2-1-3-8-5/h1-3H
- InChIKey
- IIHQNAXFIODVDU-UHFFFAOYSA-N
- SMILES
- C1(C#N)=NC=CC=N1
- CAS DataBase Reference
- 14080-23-0(CAS DataBase Reference)
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Safety
- Hazard Codes
- Xn,C,F,T
- Risk Statements
- 22-37/38-41-43-34-11-25
- Safety Statements
- 26-36/37/39-45-16-36/37
- RIDADR
- 3276
- WGK Germany
- 3
- Hazard Note
- Harmful
- HazardClass
- IRRITANT
- PackingGroup
- Ⅲ
- HS Code
- 29335990
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H317May cause an allergic skin reaction
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 646830
- Product name
- 2-Pyrimidinecarbonitrile
- Purity
- 97%
- Packaging
- 5g
- Price
- $39
- Updated
- 2025/07/31
Sigma-Aldrich
- Product number
- 646830
- Product name
- 2-Pyrimidinecarbonitrile
- Purity
- 97%
- Packaging
- 25g
- Price
- $129
- Updated
- 2025/07/31
TCI Chemical
- Product number
- C1518
- Product name
- 2-Cyanopyrimidine
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $33
- Updated
- 2025/07/31
TCI Chemical
- Product number
- C1518
- Product name
- 2-Cyanopyrimidine
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $76
- Updated
- 2025/07/31
Cayman Chemical
- Product number
- 10007121
- Product name
- 2-cyano-Pyrimidine
- Purity
- >98%
- Packaging
- 500mg
- Price
- $11
- Updated
- 2024/03/01
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2-Cyanopyrimidine Chemical Properties,Usage,Production
Chemical Properties
White to yellow to brown solid
Uses
2-Cyanopyrimidine is a potent and non-selective cysteine protease cathepsin K inhibitor and used for osteoporos.
Biological Activity
2-Cyanopyrimidine is a cathepsin k inhibitor.cathepsin k is a protease defined by its high specificity for kinins, which is involved in bone resorption. cathepsin k's ability to catabolize collagen, elastin, and gelatin allow it to break down bone and cartilage. such catabolic activity is also partially responsible for the loss of lung elasticity and recoil in emphysema. therefore, inhibitors of cathepsin k are showing great potential in the treatment of osteoporosis.
in vitro
2-cyano-pyrimidine was identified as a cathepsin k inhibitor whose basic structure and derivatives have been evaluated for the treatment of osteoporosis. enzymatic study showed that 2-cyano-pyrimidine had an ic50 value of 170 nm for inhibition of cathepsin k, elevated activity of which has been linked to the formation of osteoporosis and arthritis. moreover, cathepsin k was found to be a lysosomal cysteine protease found in osteoclasts. [1,2].
IC 50
170 nm
References
[1] altmann, e. ,aichholz, r.,betschart, c., et al. 2-cyano-pyrimidines: a new chemotype for inhibitors of the cysteine protease cathepsin k. journal of medicinal chemistry 50(4), 591-594 (2007).
[2] rankovic z et al. design and optimization of a series of novel 2-cyano-pyrimidines as cathepsin k inhibitors. bioorg med chem lett. 2010 mar 1;20(5):1524-7.
2-Cyanopyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Cyanopyrimidine manufacturers
Shaanxi Dideu New Materials Co. Ltd
- Product
- 2-Cyanopyrimidine 14080-23-0
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-05-26
Hebei Chuanghai Biotechnology Co., Ltd
- Product
- 2-Cyanopyrimidine 14080-23-0
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 5tons
- Release date
- 2024-12-02
Henan Aochuang Chemical Co.,Ltd.
- Product
- 2-Cyanopyrimidine 14080-23-0
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-28
14080-23-0, 2-CyanopyrimidineRelated Search:
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Bosentan
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Diethyl chloromalonate
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Bosentan Impurity 2