CILOSTAMIDE

Product Name: CILOSTAMIDE
CAS No.: 68550-75-4
Chemical Name: CILOSTAMIDE
Synonyms: OCP 3689;OPC 3689;CILOSTAMIDE;ciloalaMide;Cilostamide,OPC 3689;Cilostamide, 10 mM in DMSO;Cilostamide, PDE3 inhibitor;Cilostamide - CAS 68550-75-4 - Calbiochem;N-cyclohexyl-4-[(2-hydroxyquinolin-6-yl)oxy]-N-methylbutanamide;6-[3-(N-Cyclohexyl-N-methylcarbamoyl)propoxy]quinolin-2[1H]-one
CBNumber: CB1444199
Molecular Formula: C20H26N2O3
Formula Weight: 342.43
MOL File: 68550-75-4.mol

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CILOSTAMIDE Property

Melting point:: 186～188℃
Boiling point:: 594.3±50.0 °C(Predicted)
Density: 1.18±0.1 g/cm3(Predicted)
storage temp.: 0-6°C
solubility: Soluble in DMSO (up to 30 mg/ml).
form: White solid
pka: 11.12±0.70(Predicted)
color: White
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

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Safety

RIDADR: 3249
WGK Germany: 3
HazardClass: 6.1(b)
PackingGroup: III

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C7971
Product name: Cilostamide
Purity: phosphodiesterase inhibitor
Packaging: 5mg
Price: $485
Updated: 2024/03/01

Sigma-Aldrich

Product number: 231085
Product name: Cilostamide
Packaging: 10mg
Price: $332
Updated: 2024/03/01

Alfa Aesar

Product number: J65319
Product name: Cilostamide
Packaging: 10mg
Price: $135.65
Updated: 2024/03/01

Cayman Chemical

Product number: 14455
Product name: Cilostamide
Purity: ≥98%
Packaging: 5mg
Price: $74
Updated: 2024/03/01

Cayman Chemical

Product number: 14455
Product name: Cilostamide
Purity: ≥98%
Packaging: 10mg
Price: $140
Updated: 2024/03/01

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CILOSTAMIDE Chemical Properties,Usage,Production

Description

Cilostamide (68550-75-4) is a selective inhibitor of phosphodiesterase-3 (PDE3). Displays limited selectivity for PDE3A versus PDE3B (IC50 = 27 and 50 nM).1,2 Blocks PKB/Akt signaling pathway downstream via inhibition of Akt-activated PDE3B.3 Cilostamide reverses the effect of leptin on food intake and body weight.4

Uses

Serotonin receptor ligand

Uses

Cilostamide (OPC 3689) is a specific phosphodiesterase 3 (PDE3) inhibitor.

Definition

ChEBI: N-cyclohexyl-N-methyl-4-[(2-oxo-1H-quinolin-6-yl)oxy]butanamide is a member of quinolines.

Biological Activity

Selective inhibitor of type III phosphodiesterase (PDE3). Displays moderate selectivity for PDE3A isozyme vs. PDE3B (IC 50 values are 0.027 and 0.050 μ M for PDE3A and PDE3B respectively). Inhibits ADP-induced platelet aggregation (IC 50 = 16.8 μ M); anti-thrombotic. Also available as part of the Phosphodiesterase Inhibitor Tocriset™ .

Biochem/physiol Actions

Selective inhibitor of PDE3 (cGMP-inhibited phosphodiesterase); IC50 = 70 ± 9 nM. This inhibitory effect increases intracellular cAMP and inhibits platelet aggregation.

storage

Store at RT

References

1) Hidaka et al. (1979), Selective inhibitor of platelet cyclic adenosine monophosphate phosphodiesterase, cilostamide, inhibits platelet aggregation; J. Pharmacol. Exp. Ther., 211 26 2) Christensen and Torphy et al. (1994), Isozyme-Selective Phosphodiesterase Inhibitors as Antiasthmatic Agents; Annu. Rep. Med. Chem., 29 185 3) Ahmad et al. (2000), Cyclic nucleotide phosphodiesterase 3B is a downstream target of protein kinase B and may be involved in regulation of effects of protein kinase B on thymidine incorporation in FDCP2 cells; J. Immunol., 164 4678 4) Zhao et al. (2002), A phosphatidylinositol 3-kinase phosphodiesterase 3B-cyclic AMP pathway in hypothalamic action of leptin on feeding; Nat. Neuroscience, 5 727

CILOSTAMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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CILOSTAMIDE Suppliers

China 52 Germany 2 India 2 Japan 3 Switzerland 2 United Kingdom 3 United States 20 USA 1 Global 85

AdooQ BioScience, LLC

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TargetMol Chemicals Inc.

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InvivoChem

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Aladdin Scientific

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TargetMol Chemicals Inc.

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United States Biological

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Focus Biomolecules

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Abcam

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Cayman Chemical Company

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United States Biological

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MedChemExpress

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Riedel-de Haen AG

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Sciencelab.com, Inc.

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Advance Scientific & Chemical

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EMD Biosciences, Inc.

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Spectrum Chemicals & Laboratory Products

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MP Biomedicals, Inc.

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BIOMOL INTERNATIONAL, LP

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American Radiolabeled Chemicals, Inc.

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68550-75-4, CILOSTAMIDERelated Search:

ZARDAVERINE RO 20-1724 Pentoxifylline AG 1295 S- (+)-Rolipram ETAZOLATE BRL 50481 Vinpocetine ZAPRINAST ROLIPRAM Cilostazol (4S)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE EHNA HYDROCHLORIDE 4-[[3,4-(METHYLENEDIOXY)BENZYL]AMINO]-6-CHLOROQUINAZOLINE CILOSTAMIDE 2-Hydroxy-6-methoxyquinoline 6-HYDROXYQUINOLINE 4-BUTOXYACETANILIDE

OPC 3689

OCP 3689

N-CYCLOHEXYL-N-METHYL-4-(1,2-DIHYDRO-2-OXO-6-QUINOLYLOXY)BUTYRAMIDE

CILOSTAMIDE

Cilostamide,OPC 3689

ciloalaMide

6-[3-(N-Cyclohexyl-N-methylcarbamoyl)propoxy]quinolin-2[1H]-one

N-cyclohexyl-4-[(2-hydroxyquinolin-6-yl)oxy]-N-methylbutanamide

N-Cyclohexyl-4-[(1,2-dihydro-2-oxoquinolin-6-yl)oxy]-N-methylbutanamide

N-Cyclohexyl-4-[(1,2-dihydro-2-oxoquinolin-6-yl)oxy]-N-methylbutyramide

Cilostamide - CAS 68550-75-4 - Calbiochem

Butanamide, N-cyclohexyl-4-[(1,2-dihydro-2-oxo-6-quinolinyl)oxy]-N-methyl-

N-Cyclohexyl-N-methyl-4-((2-oxo-1,2-dihydroquinolin-6-yl)oxy)butanamide

OPC-3689,OPC 3689,Cilostamide,Phosphodiesterase (PDE),Inhibitor,inhibit

Cilostamide, PDE3 inhibitor

Cilostamide, 10 mM in DMSO

68550-75-4

BioChemical

Cell Biology

Cell Signaling and Neuroscience

Phosphodiesterase Inhibitors

Cyclic Nucleotide Metabolism

G Proteins and Cyclic Nucleotides

Cyclic Nucleotide related