ChemicalBook > CAS DataBase List > SB 225002

SB 225002

Product Name: SB 225002
CAS No.: 182498-32-4
Chemical Name: SB 225002
Synonyms: SB 225002;SB225002 ，S7651;CAS:182498-32-4;SB-225002;SB 225002;SB 225002 USP/EP/BP;SB225002 182498-32-4;SB225002, 10 mM in DMSO;SB 225002, non-peptide CXCR2 antagonist;SB 225002 - CAS 182498-32-4 - Calbiochem;1-(2-bromophenyl)-3-(2-hydroxy-4-nitrophenyl)urea
CBNumber: CB1455331
Molecular Formula: C13H10BrN3O4
Formula Weight: 352.14
MOL File: 182498-32-4.mol

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SB 225002 Property

Boiling point:: 401.6±45.0 °C(Predicted)
Density: 1.793±0.06 g/cm3(Predicted)
storage temp.: room temp
solubility: Soluble to 100mM in DMSO and to 50mM in ethanol
form: Yellow solid
pka: 5.29±0.10(Predicted)
color: white to beige
Sensitive: Moisture Sensitive
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChIKey: MQBZVUNNWUIPMK-UHFFFAOYSA-N
CAS DataBase Reference: 182498-32-4

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26
WGK Germany: 3
HS Code: 2921490090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0716
Product name: SB 225002
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $128
Updated: 2025/07/31

Sigma-Aldrich

Product number: 559405
Product name: SB 225002
Packaging: 1mg
Price: $98.6
Updated: 2025/07/31

TCI Chemical

Product number: B6055
Product name: SB 225002
Packaging: 10MG
Price: $147
Updated: 2025/07/31

TCI Chemical

Product number: B6055
Product name: SB 225002
Packaging: 50MG
Price: $487
Updated: 2025/07/31

Cayman Chemical

Product number: 13336
Product name: SB 225002
Purity: ≥95%
Packaging: 5mg
Price: $82
Updated: 2024/03/01

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SB 225002 Chemical Properties,Usage,Production

Description

CXCR2 (IL-8RB) is a seven-transmembrane G protein-coupled receptor whose physiological ligands include IL-8 (CXCL8) and growth related oncogene α (Gro-α; CXCL1). IL-8 and Gro-α are pro-inflammatory CXC chemokines that act as chemoattractants, especially for neutrophils, and promote angiogenesis. SB 225002 is a selective non-peptide inhibitor of CXCR2, inhibiting IL-8 binding to CXCR2 with an IC₅₀ value of 22 nM. SB225002 inhibits neutrophil chemotaxis in response to IL-8 in vitro (IC₅₀ = 20 nM) and blocks neutrophil margination induced by IL-8 in vivo (IC₅₀ = 30 nM). Similarly, SB 225002 reduces neutrophil influx, the production of inflammatory mediators, and tissue damage in TNBS-induced colitis in mice.

Uses

SB 225002 is a potent and selective CXCR2 antagonist with the ability to inhibit interleukin IL-8 binding to CXCR2.

Definition

ChEBI: 1-(2-bromophenyl)-3-(2-hydroxy-4-nitrophenyl)urea is a nitrophenol.

Biological Activity

Potent and selective CXCR2 chemokine receptor antagonist (IC 50 = 22 nM) that displays > 150-fold selectivity over CXCR1 receptors. Causes inhibition of IL-8 and GRO α -mediated calcium mobilization in HL60 cells (IC 50 values are 8 and 10 nM respectively). Prevents IL-8-induced neutrophil chemotaxis in vitro and sequestration in vivo . Inhibits HIV replication in lymphocytes and macrophages.

Biochem/physiol Actions

SB-225002 is a potent nonpeptide inhibitor of chemokine receptor CXCR2 with an IC50 of 22 nM for inhibiting interleukin IL-8 binding to CXCR2 and > 150-fold selectivity over CXCR1 receptors. CXCR2 binds many different immune cell chemoattractants. SB-225002 is crucial for cancer progression and is involved in inflammatory diseases like COPD, rheumatoid arthritis, and ulcerative colitis.

storage

Store at RT

References

[1] J R WHITE. Identification of a potent, selective non-peptide CXCR2 antagonist that inhibits interleukin-8-induced neutrophil migration.[J]. The Journal of Biological Chemistry, 1998, 273 17: 10095-10098. DOI:10.1074/jbc.273.17.10095
[2] MEIRONG DU. SB225002 promotes mitotic catastrophe in chemo-sensitive and -resistant ovarian cancer cells independent of p53 status in vitro.[J]. PLoS ONE, 2013: e54572. DOI:10.1371/journal.pone.0054572
[3] XIAO-HUA SHEN . Interleukin-8 prevents oxidative stress-induced human endothelial cell senescence via telomerase activation[J]. International immunopharmacology, 2013, 16 2: Pages 261-267. DOI:10.1016/j.intimp.2013.04.003
[4] B. LANE. Interleukin-8 Stimulates Human Immunodeficiency Virus Type 1 Replication and Is a Potential New Target for Antiretroviral Therapy[J]. Journal of Virology, 2001, 75 1: 8195-8202. DOI:10.1128/jvi.75.17.8195-8202.2001
[5] FENGJIAO WU. CXCR2 is essential for cerebral endothelial activation and leukocyte recruitment during neuroinflammation.[J]. Journal of Neuroinflammation, 2015: 98. DOI:10.1186/s12974-015-0316-6

SB 225002 Preparation Products And Raw materials

Raw materials

Preparation Products

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SB 225002 Suppliers

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182498-32-4, SB 225002Related Search:

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SB 225002

N-(2-HYDROXY-4-NITROPHENYL)-N'-(2-BROMOPHENYL)UREA

N-(2-BROMOPHENYL)-N'-(2-HYDROXY-4-NITROPHENYL)UREA

1-(2-bromophenyl)-3-(2-hydroxy-4-nitrophenyl)urea

SB 225002 - CAS 182498-32-4 - Calbiochem

SB-225002;SB 225002

Urea, N-(2-bromophenyl)-N'-(2-hydroxy-4-nitrophenyl)-

SB 225002 USP/EP/BP

SB225002 182498-32-4

SB 225002, non-peptide CXCR2 antagonist

SB225002, 10 mM in DMSO

SB225002 ，S7651

CAS:182498-32-4

182498-32-4

18298-32-4

Inhibitors

A potent, selective, and competitive antagonist of the G-protein coupled receptor CXCR2.

Antineoplastic