ChemicalBook > CAS DataBase List > Esculetin

Esculetin

Product Name
Esculetin
CAS No.
305-01-1
Chemical Name
Esculetin
Synonyms
6,7-DIHYDROXYCOUMARIN;AESCULETIN;Synonym;6,7-Dihydroxy-2H-chromen-2-one;Esculeti;ESCULETIN;ESCULETOL;Nsc 26428;Esculatin;Asculetine
CBNumber
CB1456020
Molecular Formula
C9H6O4
Formula Weight
178.14
MOL File
305-01-1.mol
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Esculetin Property

Melting point:
271-273 °C(lit.)
Boiling point:
270.35°C (rough estimate)
Density 
1.3431 (rough estimate)
refractive index 
1.4500 (estimate)
storage temp. 
2-8°C
solubility 
Solubility Almost insoluble in boiling water, ether; soluble in hot ethanol, glacial acetic acid
form 
powder
pka
1.71(at 25℃)
color 
Light yellow
PH Range
Weak blue uorescence (1.5) to strong blue uorescence (2.0)
Water Solubility 
slightly soluble
Merck 
14,3697
BRN 
152788
Major Application
antiinflammatory, Herbicides, cosmetics, teeth whitening agent, antifungal, neurodegenerative andfungal, antibacterial, antiviral, treating drug-induced weight gain, neurodegenerative and blood coagulation disorders, cancer, amyloidosis, skin impairments and baldness
InChIKey
ILEDWLMCKZNDJK-UHFFFAOYSA-N
LogP
0.980 (est)
CAS DataBase Reference
305-01-1(CAS DataBase Reference)
NIST Chemistry Reference
Coumarin, 6,7-dihydroxy-(305-01-1)
EPA Substance Registry System
Esculetin (305-01-1)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-37/39
WGK Germany 
3
RTECS 
GN6382500
HS Code 
29322090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
Y0001611
Product name
Esculetin
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
25 mg
Price
$156
Updated
2025/07/31
Sigma-Aldrich
Product number
246573
Product name
6,7-Dihydroxycoumarin
Purity
98%
Packaging
1g
Price
$79.5
Updated
2025/07/31
Sigma-Aldrich
Product number
PHL80449
Product name
Esculetin
Purity
phyproof<SUP>&#174;</SUP> Reference Substance
Packaging
25 mg
Price
$334
Updated
2025/07/31
Sigma-Aldrich
Product number
246573
Product name
6,7-Dihydroxycoumarin
Purity
98%
Packaging
5g
Price
$352
Updated
2025/07/31
TCI Chemical
Product number
E1287
Product name
Esculetin [Matrix for MALDI-TOF/MS]
Purity
>99.0%(HPLC)(T)
Packaging
200mg
Price
$29
Updated
2025/07/31
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Esculetin Chemical Properties,Usage,Production

Chemical Properties

YELLOWISH CRYSTALLINE POWDER

Uses

antifungal, hepatoprotective, IL-1 inhibitor

Uses

In the presence of esculetin and HA14-1 (sc-205911) expression of the death receptor 4 (DR4) has been observed to be upregulated and extracellular-regulated kinase (ERK) to be activated. Other studies suggest that esculetin upregulates death receptor 5 (DR5) protein expression, and enhances TRAIL-induced apoptosis. It also inhibits the activity of 12-LO (12-lipoxygenase), and decreases leukotriene biosynthesis during 5-LO inhibition.

Uses

In filters for absorption of ultraviolet light.

Definition

ChEBI: A hydroxycoumarin that is umbelliferone in which the hydrogen at position 6 is substituted by a hydroxy group. It is used in filters for absorption of ultraviolet light.

General Description

Esculetin is a derivative of coumarin, found in various plant species including Cichorium intybus (chicory), Bougainvillea spectabilis, Artemisia capillaris, etc and leaves of Citrus limonia (Rutaceae), Ceratostigma willmottianum, etc. It exhibits multiple pharmacological activities and is found to be a potent inhibitor of cyclooxygenase, 5-lipoxygenase, 12-lipoxygenase, catechol-O-methyl transferase, NADPH oxidase and xanthine oxidase enzymes.

Purification Methods

It forms prisms from AcOH, aqueous EtOH or aqueous MeOH, and provides leaflets on sublimation in a vacuum. [Kagan J Am Chem Soc 88 2617 1966, Marby et al. Phytochemistry 4 492 1965.] Esculin (the 6-glucoside) has m 215o(dec), [] D -41o (c 5, pyridine). [Beilstein 18 III/IV 1322, 18/3 V 202.]

Esculetin Preparation Products And Raw materials

Raw materials

1,4-Benzoquinone

Preparation Products

SCOPARONE
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Esculetin Suppliers

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View Lastest Price from Esculetin manufacturers

HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Product
Esculetin 305-01-1
Price
US $100.00-75.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000
Release date
2024-08-22
Hebei Chuanghai Biotechnology Co., Ltd
Product
Esculetin 305-01-1
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-28
Hebei Ganmiao New material Technology Co., LTD
Product
Esculetin 305-01-1
Price
US $10.00-7.00/kg
Min. Order
1kg
Purity
99.9%
Supply Ability
20ton
Release date
2024-06-07

305-01-1, EsculetinRelated Search:

4-HYDROXY MEPHENYTOIN 1-Hydroxyethylidene-1,1-diphosphonic acid DICUMAROL 4-Methylumbelliferone Coumarin Chrysin 1,3-Dihydroxyacetone 4-Hydroxycoumarin 7-Hydroxycoumarin Butylated Hydroxytoluene Triclosan 6-Hydroxycoumarin Esculin ERIOCITRIN AESCIN IB(SH) Eribulin Erlotinib hydrochloride Eribulin Mesylate

  • CICHORIGENIN
  • CICHERINGENIN
  • ESCULETOL
  • ESCULETIN
  • LABOTEST-BB LT00233229
  • AESCULETIN
  • AKOS 215-98
  • 6,7-DIHYDROXY-CHROMEN-2-ONE
  • 6,7-DIHYDROXYCOUMARIN
  • 2H-1-BENZOPYRAN-2-ONE, 6,7-DIHYDROXY-
  • 2H-1-Benzopyran-2-one, 6,7-dihydroxy- (9CI)
  • Coumarin, 6,7-dihydroxy-
  • Coumarin, 6,7-dihydroxy- Esculetin
  • Esculeti
  • Aesculetin(Esculetin)
  • Nsc 26428
  • 6,7-Dihydroxy-2-benzopyrone
  • 6,7-dihydroxy-2h-1-benzopyran-2-on
  • 6,7-dihydroxy-2h-1-benzopyran-2-one
  • 6,7-Dihydroxy-2H-chromen-2-one
  • 6,7-dihydroxy-coumari
  • Asculetine
  • Cichoriin aglucon
  • Cichoriin aglycon
  • cichoriinaglycon
  • Esculatin
  • Esculin aglucon
  • Esculin aglycon
  • Esculetin [Matrix for MALDI-TOF/MS]
  • Synonym
  • ESCULETIN(P)
  • Esculetine
  • ESCULETIN, 98+%
  • 6,7-DIHYROXYCOUMARIN
  • 6,7-Dihydroxycoumarin, 98+%
  • Esculetin (=6,7-DihydroxycouMarin)
  • Cichorigenin, Esculetin
  • Esculetin，Esculetine，Cichorigenin
  • 6,7-dihydroxy-1-benzopyran-2-one
  • Esculetin&gt
  • Esculetin CRS
  • Esculetin USP/EP/BP
  • TIANFU-CHEM - Esculetin
  • Esculetin (6CI)
  • Aesculetin Powder
  • Esculetin-RM
  • Dimethylacetamide Impurity 2 (Dimethylacetamide EP Impurity B)(N,N-Dimethylformamide)
  • 305-01-1
  • C9H4O2OH2
  • C9H6O4
  • Matrix Materials (MALDI-TOF-MS)
  • Mass Spectrometry
  • BioChemical
  • Biochemicals and Reagents
  • Antitumor Agents
  • Cancer Research
  • Fluorescent Probes, Labels, Particles and Stains
  • Fluorescent Labels