2-Chloro-4-fluoronitrobenzene
- Product Name
- 2-Chloro-4-fluoronitrobenzene
- CAS No.
- 2106-50-5
- Chemical Name
- 2-Chloro-4-fluoronitrobenzene
- Synonyms
- 2-chloro-4-fluoro-1-nitrobenzene;2-CHLORO-4-FLUORONITROBENZENE;4-fluoro-2-chloronitrobenzene;2-chloro-4-fluoronitrobenzenen;1-Chloro-5-fluoro-2-nitroBenzene;3-Chloro-1-fluoro-4-nitrobenzene;2-CHLORO-4-FLUORONITROBENZENE 98%;2-Chloro-4-fluoronitrobenzene >Benzene, 2-chloro-4-fluoro-1-nitro-;2-chloro-4-fluoronitrobenzen, 98%min
- CBNumber
- CB1494826
- Molecular Formula
- C6H3ClFNO2
- Formula Weight
- 175.54
- MOL File
- 2106-50-5.mol
2-Chloro-4-fluoronitrobenzene Property
- Melting point:
- 34-37°C
- Boiling point:
- 71°C/2.3mmHg(lit.)
- Density
- 1.494±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- DMSO (Sparingly), Methanol (Slightly)
- form
- Solid
- color
- Light Yellow
- InChI
- InChI=1S/C6H3ClFNO2/c7-5-3-4(8)1-2-6(5)9(10)11/h1-3H
- InChIKey
- KQOOFMWRLDRDAX-UHFFFAOYSA-N
- SMILES
- C1([N+]([O-])=O)=CC=C(F)C=C1Cl
- CAS DataBase Reference
- 2106-50-5(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 20/21/22-36/37/38-36/38-21/22
- Safety Statements
- 26-36/37/39-36/37
- RIDADR
- 2811
- Hazard Note
- Irritant
- HazardClass
- 6.1
- PackingGroup
- Ⅲ
- HS Code
- 29049090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H311Toxic in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P309IF exposed or if you feel unwell:
P310Immediately call a POISON CENTER or doctor/physician.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- C2615
- Product name
- 2-Chloro-4-fluoronitrobenzene
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $70
- Updated
- 2025/07/31
- Product number
- C2615
- Product name
- 2-Chloro-4-fluoronitrobenzene
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $278
- Updated
- 2025/07/31
- Product number
- HCH0019194
- Product name
- 2-CHLORO-4-FLUORONITROBENZENE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $637.56
- Updated
- 2021/12/16
- Product number
- CS-W003054
- Product name
- 2-Chloro-4-fluoronitrobenzene
- Purity
- 98.93%
- Packaging
- 500g
- Price
- $655
- Updated
- 2021/12/16
- Product number
- FC104964
- Product name
- 2-chloro-4-fluoro-1-nitrobenzene
- Packaging
- 50g
- Price
- $400
- Updated
- 2021/12/16
2-Chloro-4-fluoronitrobenzene Chemical Properties,Usage,Production
Uses
2-Chloro-4-fluoronitrobenzene is used in the synthesis of active pharmaceutical ingredients (APIs), particularly benzothiazole derivatives.
Synthesis
625-98-9
2106-50-5
(a) 3-Chlorofluorobenzene (240 g, 1.85 mol) was slowly added to a mixture of sulfuric acid (185 g, 1.85 mol) and nitric acid (166 g, 1.85 mol) pre-cooled to -5°C. The reaction was carried out at the same temperature for 13 hours. The reaction temperature was maintained at -5°C with continuous stirring for 3.5 hours, followed by continued stirring at the same temperature for 13 hours. Upon completion of the reaction, benzene (200 mL) and hexane (200 mL) were added to the reaction mixture for extraction. The organic phases were combined and washed sequentially with water (300 mL), sodium carbonate solution (300 mL) and water (300 mL). The organic layer was dried over anhydrous sodium sulfate and the solvent was removed by distillation under reduced pressure. The residue was purified by distillation to give 138 g of the mixed isomer. The 4-nitro isomer was isolated from the mixed isomer by crystallization and filtered to give 3-chloro-4-nitrofluorobenzene (51 g, 16.7% yield) with a melting point of 36°C-38°C.
References
[1] Patent: US4330324, 1982, A
[2] Patent: US31455, 1983, E1
[3] Patent: US4358308, 1982, A
[4] Patent: US4419122, 1983, A
[5] Patent: US4419123, 1983, A
2-Chloro-4-fluoronitrobenzene Preparation Products And Raw materials
Raw materials
Preparation Products
2-Chloro-4-fluoronitrobenzene Suppliers
- Tel
- 800-4238616
- Fax
- +1-888-520-1075 / +1-503-283-1987
- sales@tciamerica.com
- Country
- Americas
- ProdList
- 23653
- Advantage
- 75
View Lastest Price from 2-Chloro-4-fluoronitrobenzene manufacturers
- Product
- 2-Chloro-4-fluoronitrobenzene 2106-50-5
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-11
- Product
- 2-Chloro-4-fluoronitrobenzene 2106-50-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2019-07-12