ChemicalBook > CAS DataBase List > 1,2-Benzisothiazol-3(2H)-one

1,2-Benzisothiazol-3(2H)-one

Product Name
1,2-Benzisothiazol-3(2H)-one
CAS No.
2634-33-5
Chemical Name
1,2-Benzisothiazol-3(2H)-one
Synonyms
BIT;1,2-BENZISOTHIAZOLIN-3-ONE;BENZISOTHIAZOLINONE;BIT-85;Benzo[d]isothiazol-3(2H)-one;BENZISOTHIAZOLONE;proxel;1,2-Benzisothiazolin;Benzisothiazolin-3-on (BIT);1,2-benzisothiazoline-3-one
CBNumber
CB1496512
Molecular Formula
C7H5NOS
Formula Weight
151.19
MOL File
2634-33-5.mol
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1,2-Benzisothiazol-3(2H)-one Property

Melting point:
154-158 °C(lit.)
Boiling point:
360°C (rough estimate)
Density 
1.2170 (rough estimate)
vapor pressure 
0Pa at 25℃
refractive index 
1.5500 (estimate)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Soluble in dichloromethane, dimethyl sulfoxide, methanol.
pka
10.19±0.20(Predicted)
form 
Solid
color 
White to Light yellow to Light orange
Water Solubility 
1.288g/L at 20℃
InChIKey
DMSMPAJRVJJAGA-UHFFFAOYSA-N
LogP
0.7 at 20℃
CAS DataBase Reference
2634-33-5
EPA Substance Registry System
1,2-Benzisothiazolin-3-one (2634-33-5)
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Safety

Hazard Codes 
Xn,N
Risk Statements 
22-38-41-43-50
Safety Statements 
24-26-37/39-61
RIDADR 
UN 3077 9/PG 3
WGK Germany 
2
RTECS 
DE4620000
HazardClass 
IRRITANT
HazardClass 
9
PackingGroup 
Ⅲ
HS Code 
29339900
Hazardous Substances Data
2634-33-5(Hazardous Substances Data)
Toxicity
LD50 oral in rat: 1020mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H317May cause an allergic skin reaction

H318Causes serious eye damage

H400Very toxic to aquatic life

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SAB4502639
Product name
Anti-SIRP α1, C-Terminal antibody produced in rabbit
Purity
affinity isolated antibody
Packaging
100μG
Price
$506
Updated
2024/03/01
Sigma-Aldrich
Product number
561487
Product name
1,2-Benzisothiazol-3(2H)-one
Purity
97%
Packaging
5g
Price
$74.3
Updated
2024/03/01
Sigma-Aldrich
Product number
561487
Product name
1,2-Benzisothiazol-3(2H)-one
Purity
97%
Packaging
25g
Price
$216
Updated
2024/03/01
TCI Chemical
Product number
B2430
Product name
1,2-Benzisothiazol-3(2H)-one
Purity
>98.0%(GC)
Packaging
25g
Price
$82
Updated
2024/03/01
TCI Chemical
Product number
B2430
Product name
1,2-Benzisothiazol-3(2H)-one
Purity
>98.0%(GC)
Packaging
100g
Price
$239
Updated
2024/03/01
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1,2-Benzisothiazol-3(2H)-one Chemical Properties,Usage,Production

Description

BIT (1,2-Benzisothiazol-3(2H)-one) is an irritant and also a skin sensitizer. Occupational allergie contact dermatitis has been reported mainly related to the use of cutting oils and greases in paint manufacturers, pottery mouldmakers, acrylic emulsion manufacturers, plumbers, printers and lithoprinters, paper makers, an analyticallaboratory, a rubber factory, and in employees manufacturing air fresheners.

Chemical Properties

Yellow Powder

Uses

Antimicrobial agent.

Uses

Isothiazolinone BIT is widely used in industry as a preservative in water-based solutions, such as pastes, paints and cutting oils. It exists at different concentrations in the different Proxel AB, GXL, CRL, XL2, XL, HL, TN, and in Mergal K-10.

Definition

ChEBI: Benzo[d]isothiazol-3-one is an organic heterobicyclic compound based on a fused 1,2-thiazole and benzene bicyclic ring skeleton, with the S atom positioned adjacent to one of the positions of ring fusion. It has a role as a disinfectant, a platelet aggregation inhibitor, an environmental contaminant, a xenobiotic, a drug allergen and a sensitiser. It is an organonitrogen heterocyclic compound and an organic heterobicyclic compound.

Application

1,2-benzisothiazol-3(2H)-one (BIT) has been widely used in high concentrations for microbial growth control in many domestic and industrial processes, its potential eco-risk should be assessed.

General Description

1,2-Benzisothiazol-3(2H)-one is a commonly used biocide in industrial and consumer products, which possesses antimicrobial activity against gram positive and gram negative bacteria. It is mainly used in packaging, adhesives, detergents, disinfectants, sunscreen lotions, paints and lubricants.

Flammability and Explosibility

Not classified

Contact allergens

1,2-Benzisothiazol-3(2H)-one, both an irritant and a skin sensitizer, is widely used in industry as a preservative in water-based solutions such as pastes, paints, and cutting oils. Occupational dermatitis has been reported mainly due to cutting fluids and greases, in paint manufacturers, pottery moldmakers, acrylic emulsions manufacturers, plumber,printers and lithoprinters, paper makers, analytical laboratory, rubber factory, and employees manufacturing air fresheners. It is also a preservative in vinyl gloves.

Safety Profile

Moderately toxic by ingestion.When heated to decomposition it emits toxic vapors ofNOx and SOx.

Toxicity evaluation

Isothiazolinones, such as 1,2-benzisothiazol-3(2H)-one (BIT), are widely used as biocides for bacterial growth control in many domestic and industrial processes. Despite their advantages as biocides, they are highly toxic and pose a potential risk to the environment.  BIT could seriously inhibit the growth of Scenedesmus sp. LX1, Chlorella sp. HQ, and Chlamydomonas reinhardtii with half maximal effective concentrations at 72 h (72h-EC50) of 1.70, 0.41, and 1.16 mg/L, respectively. The primary inhibition mechanism was the BIT-induced damage to microalgal photosynthetic systems.

1,2-Benzisothiazol-3(2H)-one Preparation Products And Raw materials

Raw materials

Preparation Products

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1,2-Benzisothiazol-3(2H)-one Suppliers

Americas 1 Argentina 1 Australia 1 Canada 3 China 492 Czech Republic 1 Europe 4 France 1 Germany 11 India 22 Japan 4 Malaysia 1 Slovakia 1 South Korea 4 Switzerland 1 The Netherlands 2 United Arab Emirates 1 United Kingdom 12 United States 46 USA 1 Global 610
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View Lastest Price from 1,2-Benzisothiazol-3(2H)-one manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Benzisothiazolone 2634-33-5
Price
US $32.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000kg/week
Release date
2024-05-15
Hebei Weibang Biotechnology Co., Ltd
Product
1,2-Benzisothiazolin-3-one 2634-33-5
Price
US $10.00/KG
Min. Order
1KG
Purity
99.5%
Supply Ability
100
Release date
2024-10-28
Hebei Chuanghai Biotechnology Co,.LTD
Product
1,2-benzisothiazolin-3-one 2634-33-5
Price
US $12.00/KG
Min. Order
1KG
Purity
99.8%
Supply Ability
5000kg
Release date
2024-08-21

2634-33-5, 1,2-Benzisothiazol-3(2H)-oneRelated Search:

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  • Benzisothiazolin-3-on (BIT)
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  • 1,2-BENZISOTHIAZOL-3-ONE (BIT)
  • 1,2-Benzisothiazoline-3(2H)-one
  • 1,2-BENZISOTHIAZOL-3(2H)-ONE HYDRATE
  • 1,2-BENZISOTHIAZOLIN-3-ONE (BIT) 98.5%
  • 1,2-Benisothiazolin-3-One-2-Sodium Salt
  • 1,2-Benzisothiazolin-3-One(Bit)