ChemicalBook > CAS DataBase List > N-BOC-SERINOL, 97

N-BOC-SERINOL, 97

Product Name: N-BOC-SERINOL, 97
CAS No.: 125414-41-7
Chemical Name: N-BOC-SERINOL, 97
Synonyms: Boc-ser.ol;Boc-Serinol;Boc-L-Ser-OL;N-BOC-SERINOL, 97;N-Boc-serinol 97%;N-Boc-serinol;2-(Boc-amino)-1,3-propanediol;tert-Butyl (1,3-dihydroxypropan-2-yl);t-Butyl 1,3-dihydroxypropan-2-ylcarbamate;tert-Butyl (1,3-dihydroxypropan-2-yl)carbaMate
CBNumber: CB1498945
Molecular Formula: C8H17NO4
Formula Weight: 191.22
MOL File: 125414-41-7.mol

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N-BOC-SERINOL, 97 Property

Melting point:: 85-89 °C
Boiling point:: 363.0±32.0 °C(Predicted)
Density: 1.136±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
form: Solid
pka: 11.60±0.46(Predicted)
color: White to off-white
InChI: InChI=1S/C8H17NO4/c1-8(2,3)13-7(12)9-6(4-10)5-11/h6,10-11H,4-5H2,1-3H3,(H,9,12)
InChIKey: JHBKBRLRYPYBLP-UHFFFAOYSA-N
SMILES: C(OC(C)(C)C)(=O)NC(CO)CO

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Safety

Hazard Codes: Xi
Risk Statements: 36
Safety Statements: 26
WGK Germany: 3
HS Code: 2924190090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H319Causes serious eye irritation
Precautionary statements: P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 661074
Product name: N-Boc-serinol
Purity: 97%
Packaging: 1g
Price: $44.84
Updated: 2025/07/31

Sigma-Aldrich

Product number: 661074
Product name: N-Boc-serinol
Purity: 97%
Packaging: 5g
Price: $140
Updated: 2025/07/31

TRC

Product number: B700348
Product name: tert-Butyl(1,3-Dihydroxypropan-2-yl)carbamate
Packaging: 5g
Price: $710
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0156468
Product name: N-BOC-SERINOL
Purity: 95.00%
Packaging: 1G
Price: $852.55
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB156039
Product name: tert-Butyl (1,3-dihydroxypropan-2-yl)carbamate
Packaging: 100g
Price: $1050
Updated: 2021/12/16

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N-BOC-SERINOL, 97 Chemical Properties,Usage,Production

Description

T-Butyl 1,3-dihydroxypropan-2-ylcarbamate is a branched PEG derivative with biotin and two hydroxyl moieties. The hydroxyl groups enable further derivatization or replacement with other reactive functional groups. The Boc group can be deprotected under mild acidic conditions to form the free amine.

Uses

N-Boc-serinol is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Synthesis

24424-99-5

534-03-2

125414-41-7

The general procedure for the synthesis of N-BOC-serinol from di-tert-butyl dicarbonate and serinol was as follows: di-tert-butyl dicarbonate (24.0 g, 0.1 mol) was added to an ethanol (100 mL) solution of serinol (1.00 g, 0.1 mol). The reaction mixture was stirred at room temperature for 16 hours. After completion of the reaction, the reaction solution was concentrated to dryness under vacuum to afford N-BOC-serinol (21.0 g, yield: 100%) as a white solid.

IC 50

Alkyl/ether

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

N-BOC-SERINOL, 97 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from N-BOC-SERINOL, 97 manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: Boc-ser.ol 125414-41-7
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1T+
Release date: 2024-01-16

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125414-41-7

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