PD184352

Product Name: PD184352
CAS No.: 212631-79-3
Chemical Name: PD184352
Synonyms: CS-333;Ci-1040;PD184352;PD 184352, >=98%;CI-1040, PD-184352;PD184352 USP/EP/BP;PD 184352;CI-1040;PD-184352;CI1040;PD-184352; CI 1040 (PD184352);2-[(2-CHLORO-4-IODOPHENYL) AMINO]-N-(CYCLOPROPYLME;2-(2-CHLORO-4-IODOANILINO)-N-(CYCLOPROPYLMETHOXY)-3,4-DIFLUOROBENZAMIDE
CBNumber: CB1500875
Molecular Formula: C17H14ClF2IN2O2
Formula Weight: 478.66
MOL File: 212631-79-3.mol

More

Less

PD184352 Property

Melting point:: 166-169°C
Density: 1.747±0.06 g/cm3(Predicted)
storage temp.: room temp
solubility: DMSO: ≥30mg/mL
pka: -5.58±0.50(Predicted)
form: powder
color: white to tan

More

Less

Safety

Hazard Codes: N
Risk Statements: 50/53
Safety Statements: 60-61
RIDADR: UN 3077 9 / PGIII
WGK Germany: 3
HS Code: 2924297099

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H400Very toxic to aquatic life
Precautionary statements: P273Avoid release to the environment.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PZ0181
Product name: PD 184352
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $129
Updated: 2024/03/01

Sigma-Aldrich

Product number: PZ0181
Product name: PD 184352
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $516
Updated: 2024/03/01

TCI Chemical

Product number: P2174
Product name: PD 184352
Packaging: 25MG
Price: $243
Updated: 2024/03/01

TCI Chemical

Product number: P2174
Product name: PD 184352
Packaging: 100MG
Price: $726
Updated: 2024/03/01

Cayman Chemical

Product number: 11580
Product name: CI-1040
Purity: ≥98%
Packaging: 5mg
Price: $81
Updated: 2024/03/01

More

Less

PD184352 Chemical Properties,Usage,Production

Chemical Properties

Off-White to Pale Beige Solid

Uses

An inhibitor of ERK signaling pathway. A MAP kinase inhibitor. Potent MEK inhibitor.

Definition

ChEBI: 2-(2-chloro-4-iodoanilino)-N-(cyclopropylmethoxy)-3,4-difluorobenzamide is an aminobenzoic acid.

Biological Activity

pd184352 (also known as ci-1040), a benzhydroxamate derivative, is a potent and highly selective mek1/2, two members of the family of mapkks, inhibitor that inhibits purified mek1 with ic50 of 17 nm in a non-atp and non-erk1/2 competitive manner [1].pd184352 binds to a hydrophobic pocket, which is located in a region with low sequence homology to other kinases, adjacent to the mg-atp binding site of mek1 and mek2 inducing a conformational change in un-phosphorylated mek1/2 and hence inactivating the un-phosphorylated mek1/2 [1].pd184352 has been found to be actively against tumors, where it inhibits the growth of colon carcinomas in mouse xenograft models [1].

Biochem/physiol Actions

PD184352 (CI-1040) is a highly selective non-competitive inhibitor of MEK (MKK1; MAPK kinase) and the closely related MKK2. It has anti-cancer activity, suppresses the ERK pathway, and has been used along with other classes of inhibitors to establish embryonic stem cell lines.

storage

Store at +4°C

References

[1] frémin c, meloche s. from basic research to clinical development of mek1/2 inhibitors for cancer therapy. j hematol oncol. 2010 feb 11;3:8. doi: 10.1186/1756-8722-3-8.

PD184352 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

PD184352 Suppliers

Canada 1 China 110 Germany 1 India 3 Japan 1 The Netherlands 1 United Kingdom 4 United States 25 Global 146

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4861
Advantage: 58

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2782
Advantage: 58

Target molecule Corp.

Tel: 857-239-0968
Fax: 857-239-8801
Email: service1@targetmol.com
Country: United States
ProdList: 2559
Advantage: 60

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4660
Advantage: 60

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32161
Advantage: 58

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
Advantage: 58

Cckinase, Inc.

Tel: +1 (732)236-3202
Email: sales@cckinase.com
Country: United States
ProdList: 2738
Advantage: 58

Alchem Pharmtech,Inc.

Tel: 8485655694
Email: sales@alchempharmtech.com
Country: United States
ProdList: 63687
Advantage: 58

Aladdin Scientific

Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

United States Biological

Tel: --
Fax: --
Email: sales@advtechind.com
Country: United States
ProdList: 6075
Advantage: 58

ApexBio Technology

Tel: --
Fax: --
Email: sales@apexbt.com
Country: United States
ProdList: 6251
Advantage: 58

LC Laboratories

Tel: --
Fax: --
Email: custserv@lclabs.com
Country: United States
ProdList: 503
Advantage: 50

Cayman Chemical Company

Tel: --
Fax: --
Email: cayman@caymanchem.com
Country: United States
ProdList: 6213
Advantage: 81

United States Biological

Tel: --
Fax: --
Email: chemicals@usbio.net
Country: United States
ProdList: 6214
Advantage: 80

Creative Enzymes

Tel: --
Fax: --
Email: info@creative-enzymes.com
Country: United States
ProdList: 6057
Advantage: 58

MedChemExpress

Tel: --
Fax: --
Email: sales@medchemexpress.com
Country: United States
ProdList: 6398
Advantage: 58

Axon Medchem LLC

Tel: --
Fax: --
Email: info@axonmedchem.com
Country: United States
ProdList: 763
Advantage: 58

Riedel-de Haen AG

Tel: --
Fax: --
Country: United States
ProdList: 6773
Advantage: 87

Matrix Scientific

Tel: --
Fax: --
Email: sales@matrixscientific.com
Country: United States
ProdList: 6632
Advantage: 80

Selleck Chemicals LLC

Tel: --
Fax: --
Email: info@selleckchem.com
Country: United States
ProdList: 824
Advantage: 60

Exlcusive Chemistry Ltd

Tel: --
Fax: --
Country: United States
ProdList: 446
Advantage: 71

AK Scientific, Inc.

Tel: --
Fax: --
Email: sales@aksci.com
Country: United States
ProdList: 6347
Advantage: 65

Santa Cruz Biotechnology, Inc.

Tel: --
Fax: --
Email: scbt@scbt.com
Country: United States
ProdList: 3597
Advantage: 60

LKT Laboratories, Inc.

Tel: --
Fax: --
Email: info@lktlabs.com
Country: United States
ProdList: 2164
Advantage: 64

Medical Isotopes

Tel: --
Fax: --
Email: stohler@medicalisotopes.com
Country: United States
ProdList: 6181
Advantage: 68

More

Less

View Lastest Price from PD184352 manufacturers

Career Henan Chemical Co

Product: PD184352 212631-79-3
Price: US $8.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10tons
Release date: 2018-12-24

212631-79-3, PD184352Related Search:

PD318088 CHLOROPHENYLSILANE 97 Phenyl carbamate Selumetinib Trametinib SB 203580 LY 294002 HYDROCHLORIDE CHIR-99021 Rapamycin PD 98059 PD 166793 PD 0325901 PD173955 PD 166285 2-Chloro-4-iodoaniline 1-Chloro-3-iodobenzene CYCLOPROPYL METHOXYLAMINE HYDROCHLORIDE PD184352 (CI-1040)

CI1040;PD-184352; CI 1040 (PD184352)

CS-333

PD184352

2-[(2-Chloro-4-iodophenyl)amino]-N-(cyclopropylmethoxy)-3,4-difluorobenzamide

2-(2-CHLORO-4-IODOANILINO)-N-(CYCLOPROPYLMETHOXY)-3,4-DIFLUOROBENZAMIDE

2-[(2-CHLORO-4-IODOPHENYL) AMINO]-N-(CYCLOPROPYLME

Benzamide, 2-[(2-chloro-4-iodophenyl)amino]-N-(cyclopropylmethoxy)-3,4-difluoro-

Ci-1040

CI-1040, PD-184352

PD 184352;CI-1040;PD-184352

3,4-Difluoro-2-(2-chloro-4-iodophenylaMino)-N-cyclopropylMethoxybenzaMide

2-(2-Chloro-4-iodophenylamino)-N-(cyclopropylmethoxy)-3,4-difluorobenzamide PD184352

CI-10402-(2-chloro-4-iodophenylamino)-N-(cyclopropylmethoxy)-3,4-difluorobenzamide

PD 184352, >=98%

PD184352 USP/EP/BP

212631-79-3

C17H14ClF2IN2O2

Anti-cancer&immunity

MAPK

Pfizer compounds

Amines

Aromatics

Intermediates & Fine Chemicals

Pharmaceuticals

Inhibitors

All Inhibitors