ChemicalBook > CAS DataBase List > 6-bromo-1,2,3,4-tetrahydroisoquinoline

6-bromo-1,2,3,4-tetrahydroisoquinoline

Product Name: 6-bromo-1,2,3,4-tetrahydroisoquinoline
CAS No.: 226942-29-6
Chemical Name: 6-bromo-1,2,3,4-tetrahydroisoquinoline
Synonyms: 6-bromo-1,2,3,4-tetrahydrois;Isoquinoline,6-broMo-1,2,3,4-tetrahydro-;6-Bromo-1,2,3,4-tetrahydroisoquinoline,95%;6-Bromo-1,2,3,4-tetrahydroisoquinoline HCl;6-bromo-1,2,3,4-tetrahydroisoquinoline ISO 9001：2015 REACH
CBNumber: CB1547346
Molecular Formula: C9H10BrN
Formula Weight: 212.09
MOL File: 226942-29-6.mol

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6-bromo-1,2,3,4-tetrahydroisoquinoline Property

Boiling point:: 283℃
Density: 1.428
Flash point:: 125℃
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 9.26±0.20(Predicted)
form: Solid
Appearance: White to yellow Solid
InChI: InChI=1S/C9H10BrN/c10-9-2-1-8-6-11-4-3-7(8)5-9/h1-2,5,11H,3-4,6H2
InChIKey: URDGCPQHZSDBRG-UHFFFAOYSA-N
SMILES: C1C2=C(C=C(Br)C=C2)CCN1
CAS DataBase Reference: 226942-29-6

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: B699530
Product name: 6-Bromo-1,2,3,4-tetrahydroisoquinoline
Packaging: 50mg
Price: $60
Updated: 2021/12/16

Ark Pharm

Product number: P000505914
Product name: 6-Bromo-1,2,3,4-tetrahydroisoquinoline
Purity: 95%
Packaging: 1g
Price: $45
Updated: 2021/12/16

Matrix Scientific

Product number: 072670
Product name: 6-Bromo-1,2,3,4-tetrahydroisoquinoline
Purity: 95+%
Packaging: 1g
Price: $49
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB42090
Product name: 6-Bromo-1,2,3,4-tetrahydroisoquinoline
Packaging: 1g
Price: $55
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB42090
Product name: 6-Bromo-1,2,3,4-tetrahydroisoquinoline
Packaging: 2g
Price: $100
Updated: 2021/12/16

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6-bromo-1,2,3,4-tetrahydroisoquinoline Chemical Properties,Usage,Production

Synthesis

34784-05-9

226942-29-6

NaBH4 (3.46 g, 91.51 mmol) was slowly added to a solution of acetic acid (90 mL) containing 6-bromoisoquinoline (4.76 g, 22.88 mmol) at room temperature with continuous stirring for 1.5 h. The reaction was carried out using a mixture of ethyl acetate and THF. Upon completion of the reaction, water was added to the mixture and the pH was adjusted to 8 with an aqueous solution of 8 N sodium hydroxide.Subsequently, the reaction mixture was extracted three times using a solvent mixture of ethyl acetate/THF (3:1, v/v). The organic layers were combined, washed with water and dried with magnesium sulfate. After removal of the solvent by evaporation under reduced pressure, the residue was purified by silica gel column chromatography (using NH silica gel, solvent gradient: 20%→90% ethyl acetate/hexanes) to afford the target compound, 6-bromo-1,2,3,4-tetrahydroisoquinoline (3.26 g, 15.37 mmol, 67.2% yield), as a colorless oil.1H NMR (300 MHz, CDCl3 ) data were as follows: δ 1.63 (1H, s), 2.77 (2H, t, J = 6.0 Hz), 3.11 (2H, t, J = 5.9 Hz), 3.95 (2H, s), 6.85-6.90 (1H, m), 7.21-7.26 (2H, m).

References

[1] Patent: EP3192791, 2017, A1. Location in patent: Paragraph 0593
[2] Patent: WO2013/80222, 2013, A1. Location in patent: Page/Page column 39
[3] Applied Catalysis A: General, 2018, vol. 560, p. 37 - 41

6-bromo-1,2,3,4-tetrahydroisoquinoline Preparation Products And Raw materials

Raw materials

Sodium sulfate Sodium chloride Triethylamine Ethyl chloroformate Polyphosphoric acid Tetrahydrofuran Diethyl ether Ethyl acetate Lithium Aluminum Hydride Hydrochloric acid Sodium bicarbonate Dichloromethane Methanol Sodium hydroxide Magnesium sulfate Borane-tetrahydrofuran complex Sulfuric acid 3-Bromophenylacetonitrile Ammonia

Preparation Products

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View Lastest Price from 6-bromo-1,2,3,4-tetrahydroisoquinoline manufacturers

Honest Joy Holdings Limited

Product: 6-Bromo-1,2,3,4-tetrahydroisoquinoline 226942-29-6
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98.7%
Supply Ability: 100 tons
Release date: 2022-01-26

Career Henan Chemical Co

Product: 6-bromo-1,2,3,4-tetrahydroisoquinoline 226942-29-6
Price: US $1.00/IU
Min. Order: 1KG
Purity: 99%
Supply Ability: G/KG/T
Release date: 2019-12-24

226942-29-6, 6-bromo-1,2,3,4-tetrahydroisoquinolineRelated Search:

6-BROMO-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROCHLORIDE 6-BROMO-1,2,3,4-TETRAHYDROQUINOLINE HYDROCHLORIDE 6-BROMO-1,2,3,4-TETRAHYDROQUINOLINE 6-BROMO-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE 6-bromo-1,2,3,4-tetrahydroisoquinoline 1,2,3,4-TETRAHYDROISOQUINOLINE 6-BROMO-3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBOXYLIC ACID TERT-BUTYL ESTER 6-BROMO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-1-CARBOXYLIC ACID 5,6,7,8-TETRAHYDROISOQUINOLINE ETHYL 2-(4-FLUORO-PHENYL)-6-BROMO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-1-CARBOXYLATE 6'-BROMO-2',3'-DIHYDRO-1'H-SPIRO[CYCLOPENTANE-1,4'-ISOQUINOLINE] ETHYL 2-(4-CHLORO-PHENYL)-6-BROMO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-1-CARBOXYLATE 6-BROMO-3-METHYL-1,2,3,4-TETRAHYDRO-ISOQUINOLINE 6-Bromo-2-methanesulfonyl-1,2,3,4-tetrahydroisoquinoline 6'-Bromo-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinoline 6-BROMO-2-(4-CHLORO-PHENYL)-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-1-CARBOXYLIC ACID ETHYL 6-BROMO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-1-CARBOXYLATE 2-CBZ-6-BROMO-3,4-DIHYDRO-1H-ISOQUINOLINE-1-CARBOXYLIC ACID

Isoquinoline,6-broMo-1,2,3,4-tetrahydro-

6-Bromo-1,2,3,4-tetrahydroisoquinoline HCl

6-Bromo-1,2,3,4-tetrahydroisoquinoline,95%

6-bromo-1,2,3,4-tetrahydroisoquinoline ISO 9001：2015 REACH

6-bromo-1,2,3,4-tetrahydrois

226942-29-6