Phenyl dichlorophosphate Property

Melting point:

-1 °C

Boiling point:

241-243 °C (lit.)

Density 

1.412 g/mL at 25 °C (lit.)

vapor pressure 

2.33Pa at 25℃

refractive index 

n20/D 1.523(lit.)

Flash point:

>230 °F

storage temp. 

2-8°C

solubility 

soluble in Chloroform

form 

Liquid

color 

Clear colorless to very slightly brown

Water Solubility 

Decomposes

Sensitive 

Moisture Sensitive

Merck 

14,7282

BRN 

511863

Stability:

Moisture Sensitive

InChIKey

TXFOLHZMICYNRM-UHFFFAOYSA-N

CAS DataBase Reference

770-12-7(CAS DataBase Reference)

NIST Chemistry Reference

Phosphorodichloridic acid, phenyl ester(770-12-7)

EPA Substance Registry System

Phosphorodichloridic acid, phenyl ester (770-12-7)

Safety

Hazard Codes 

C

Risk Statements 

34-37

Safety Statements 

26-36/37/39-45

RIDADR 

UN 3265 8/PG 2

WGK Germany 

3

RTECS 

TD4393000

F 

10

TSCA 

Yes

HazardClass 

8

PackingGroup 

II

HS Code 

29209085

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

P405Store locked up.

Phenyl dichlorophosphate Chemical Properties,Usage,Production

Chemical Properties

clear colourless to very slightly brown liquid

Uses

Reagent for the preparation of phosphate diesters.

Uses

Reagent for preparation of phosphate diesters. Phenyl dichlorophosphate is used in the preparation of symmetrical phosphate diesters. It is used as a phosphorylating agent for alcohols and amines. It is also involved in the preparation of phenylphosphoro di-(1-imidazolidate) and 2-phenyl-bis-triazoloylphosphate, which is used in peptide synthesis. It plays a vital role in the Pfitzner-Moffatt oxidation which involves oxidation of alcohols to the corresponding aldehydes and ketones. Furthermore, it is utilized in Beckmann rearrangement for the preparation of N-phenylacetamide from acetophenone oxime.

Uses

In organic synthesis for preparation of lactams, phosphate diesters and for oxidation reactions.

Preparation

The preparation of Phenyl dichlorophosphate is as follows:160 g (1 mol) of phosphorus oxychloride and 1 g of titanium tetrachloride were respectively added to a four-necked flask to carry out the reaction, and the temperature was raised to 70-80° C., and phenol (94 g, 1 mol) was slowly added dropwise. The phenol addition time was about 2- 3 hours,After completion of the dropwise addition, the reaction is maintained at 80-90° C. for 3-5 hours. After no hydrogen chloride is evolved, the reaction is completed. After the reaction, the phosphorus oxychloride is distilled under reduced pressure, the vacuum degree is 30-100 KPa, and the distillation temperature is 30-100° C. Distillation under reduced pressure to obtain the intermediate of the mixture, a mono-substituted and di-substituted mixture of phosphorus oxychloride, the ratio of the mixture is 5:5, gas phase analysis to obtain the intermediate of the mixture, the yield of the intermediate is 95%, phosphorus oxychloride The recovery rate is 95% (calculated as phosphorus oxychloride).

General Description

A liquid. May severely irritate skin, eyes and mucous membranes.

Air & Water Reactions

About the same density as water and moderately soluble in water.

Reactivity Profile

An hologenated organophosphate. Organophosphates are susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides.

Hazard

May cause severe skin, eye, and mucous membrane irritation; Reacts violently with water; Causes burns; Inhalation may cause corrosive injuries to upper respiratory tract and lungs; Toxic by ingestion; Highly toxic by skin absorption; Dermal LD50 (guinea pig) = 14-400 mg/kg.

Health Hazard

TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

Fire Hazard

Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Some are oxidizers and may ignite combustibles (wood, paper, oil, clothing, etc.). Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated.