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Tigogenin

Product Name
Tigogenin
CAS No.
77-60-1
Chemical Name
Tigogenin
Synonyms
Nsc93754;TIGOGENIN;Ticogenin;Sisalagenin;TIGOGENIN90%;Tigogenin-RM;Sisal saponin;Spirostan-3-ol;SMILAGENIN(RG);Trigonegenin B
CBNumber
CB1669512
Molecular Formula
C27H44O3
Formula Weight
416.64
MOL File
77-60-1.mol
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Tigogenin Property

Melting point:
202-204°C
alpha 
-68 º (c=0.8g/100ml, CHCl3)
Boiling point:
474.91°C (rough estimate)
Density 
1.0362 (rough estimate)
refractive index 
1.4700 (estimate)
storage temp. 
-20°C Freezer, Under inert atmosphere
solubility 
Chloroform (Slightly)
pka
15.14±0.70(Predicted)
form 
Solid
color 
Off-White
optical activity
-67.218 (c 1, CHCl3)
CAS DataBase Reference
77-60-1(CAS DataBase Reference)
NIST Chemistry Reference
Tigogenin(77-60-1)
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Safety

RTECS 
WH1443500
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHL83916
Product name
Tigogenin
Purity
phyproof? Reference Substance
Packaging
10MG
Price
$457
Updated
2024/03/01
Cayman Chemical
Product number
30137
Product name
Tigogenin
Packaging
10mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
30137
Product name
Tigogenin
Packaging
250mg
Price
$745
Updated
2024/03/01
Cayman Chemical
Product number
30137
Product name
Tigogenin
Packaging
50mg
Price
$193
Updated
2024/03/01
Cayman Chemical
Product number
30137
Product name
Tigogenin
Packaging
100mg
Price
$341
Updated
2024/03/01
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Tigogenin Chemical Properties,Usage,Production

Description

Tigogenin is a steroidal sapogenin that has been found in A. sisalana and has diverse biological activities. It increases the proliferation rate of, as well as mRNA levels of genes encoding the osteoblastic differentiation markers Cbfa1, collagen type I, and osteocalcin in, mouse bone marrow stromal cells (BMSCs) in a concentration-dependent manner. It also increases matrix calcium deposition in BMSCs when used at concentrations of 30 and 90 μM. Tigogenin is active against the fungus A. fumigatus (MIC50 = 16 μg/ml). It inhibits carrageenan-induced paw edema in rats when administered at a dose of 4.2 μg/kg.

Chemical Properties

mp 196-208C° LOD ≤0.5%

Uses

Tigogenin is a saponin structurally similar to Diosgenin (D484700) and acts as a natural plant steroid which induces apoptosis in rheumatoid arthritic fibroblast-like synoviocytes.

Definition

ChEBI: Tigogenin is a widely used steroidal sapogenin isolated from several plant species and used for synthesizing steroid drugs. It has a role as a gout suppressant and a plant metabolite.

Tigogenin Preparation Products And Raw materials

Raw materials

Preparation Products

Androst-3-ol-17-one 3-p-toluenesulfonate 3-Acetyloxy-16-methylpregna-9(11),16-dien-20-one 3-Acetyloxypregn-16-en-20-one 16-Methylpregnane-17,21-diol-3,20-dione 21-acetate 17-alpha-hydroxy-16-alpha-methyl-3,20-dioxopregna- 1,4-dien-21-yl acetate Oxymetholone 16,17-Epoxy-3-hydroxy-16-methyl-pregn-9(11)-ene-20-one-3-acetate 3beta-hydroxy-5alpha-pregna-9(11),16-dien-20-one 3-acetate
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Tigogenin Suppliers

China 189 Europe 2 Germany 1 India 1 Switzerland 1 United Kingdom 5 United States 26 Global 225
ALB Technology Limited
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EMMX Biotechnology LLC
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TargetMol Chemicals Inc.
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marketing@targetmol.com
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Alchem Pharmtech,Inc.
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Aladdin Scientific
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View Lastest Price from Tigogenin manufacturers

Shanghai Standard Technology Co., Ltd.
Product
Tigogenin 77-60-1
Price
US $0.00/mg
Min. Order
5mg
Purity
≥98%(HPLC)
Supply Ability
10 g
Release date
2019-11-22
Honest Joy Holdings Limited
Product
Tigogenin 77-60-1
Price
US $0.00/KG
Min. Order
1KG
Purity
97.9%
Supply Ability
100 tons
Release date
2022-02-18
Longyan Tianhua Biological Technology Co., Ltd
Product
Tigogenin 77-60-1
Price
US $30.00/KG
Min. Order
1KG
Purity
99
Supply Ability
999
Release date
2020-10-29

77-60-1, TigogeninRelated Search:

Ginsenoside Rh2 Ginseng extract Saponin TRIBULOSIDE Hecogenin Diosgenin Escin PAMAQUESIDE DIGITONIN TIQUESIDE HECOGENIN ACETATE Escin sodium (25R)-5ALPHA-SPIROSTAN-2ALPHA,3BETA-DIOL Ginsenosides SMILAGENIN TIGOGENIN ACETATE nigrumnin I GSK-3 BETA

  • TIGOGENIN
  • (25r)-5-alpha-spirostan-3-beta-o
  • 25R,5ALPHA-SPIROSTAN-3BETA-OL
  • 5-ALPHA, 20-ALPHA, 22-ALPHA, 25D-SPIROSTAN-3-BETA-OL
  • (25R)-5-Spirostan-3-ol
  • (3-beta,5-alpha,25r)-spirostan-3-o
  • 5-alpha-spirostan-3-beta-ol
  • 5alpha-Spirostan-3beta-ol, (25R)-
  • Spiro[8H-naphth[2',1':4,5]indeno[2,1-b]furan-8,2'-[2H]pyran], spirostan-3-ol deriv.
  • Spirostan-3-ol
  • Spirostan-3-ol, (3beta,5alpha,25R)-
  • Ticogenin
  • Tsosarsasaprgein
  • (5alpha,25R)-spirostan-3beta-ol
  • TIGOGENIN90%
  • SMILAGENIN(RG)
  • (3,5,25R)-3-Hydroxy-spirostane
  • (3-beta,5-alpha,25r)-spirostan-3-ol
  • TIGOGENIN (91%: 95%) (5A,25R)-SPIROSTAN-3B-OL)
  • Sisalagenin
  • (25R)-5a-Spirostan-3b-ol
  • (25R)-3β-Hydroxy-5α-spirostane
  • Trigonegenin B
  • Nsc93754
  • 22-Isoallospirostan-3β-ol
  • (2aS,2'R,4S,5'R,6aS,6bS,8aS,8bR,9S,11aS,12aS,12bR)-5',6a,8a,9-TetraMethyldocosahydrospiro[naphtho[2',1':4,5]indeno[2,1-b]furan-10,2'-pyran]-4-ol
  • 22-Isoallospirostan-3β-ol
  • (25R)-5.α.-Spirostan-3.β.-ol
  • (2aS,4S,5'R,6aS,6bS,8aS,8bR,9S,10R,11aS,12aS,12bR)-5',6a,8a,9-Tetramethyldocosahydrospiro[naphtho[2',1':4,5]indeno[2,1-b]furan-10,2'-pyran]-4-ol
  • 5α, 20α, 22α, 25D-SPIROSTAN-3β-OL
  • Sisal saponin
  • (2aS,4S,5'R,6aS,6bS,8aS,8bR,9S,10R,11aS,12aS,12bR)-5',6a,8a,9-Tetramethyldocosahydrospiro[naphtho[2',1':4,5]indeno[2,1-b]furan-10,2'-pyran]-4-ol
  • Tigogenin-RM
  • 77-60-1
  • Miscellaneous Natural Products