ChemicalBook > CAS DataBase List > 3-Bromo-2-fluorobenzoic acid

3-Bromo-2-fluorobenzoic acid

Product Name
3-Bromo-2-fluorobenzoic acid
CAS No.
161957-56-8
Chemical Name
3-Bromo-2-fluorobenzoic acid
Synonyms
BUTTPARK 14\01-30;3-Bromo-2-fluorobenzoic;3-BROMO-2-FLUOROBENZOIC ACID;Benzoic acid, 3-bromo-2-fluoro-;3-Bromo-2-fluorobenzoic acid,98%;3-Bromo-2-fluorobenzoic Acid >3-Bromo-2-fluorobenzoic acid 97%+;3-Bromo-2-fluorobenzoic acid 97%;2-fluoro-3-bromobenzoic acid,3-Bromo-2-fluoro-benzoic acid,3-Bromo-2-Fluorobenzoic acid
CBNumber
CB1670749
Molecular Formula
C7H4BrFO2
Formula Weight
219.01
MOL File
161957-56-8.mol
More
Less

3-Bromo-2-fluorobenzoic acid Property

Melting point:
168 °C
Boiling point:
298.2±25.0 °C(Predicted)
Density 
1.789±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
form 
powder to crystal
pka
2.88±0.10(Predicted)
color 
White to Light yellow
InChI
InChI=1S/C7H4BrFO2/c8-5-3-1-2-4(6(5)9)7(10)11/h1-3H,(H,10,11)
InChIKey
UVKURTLVTLRSSM-UHFFFAOYSA-N
SMILES
C(O)(=O)C1=CC=CC(Br)=C1F
CAS DataBase Reference
161957-56-8(CAS DataBase Reference)
More
Less

Safety

Hazard Codes 
Xi
Risk Statements 
36
Safety Statements 
26
HazardClass 
IRRITANT
HS Code 
2916399090
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

TCI Chemical
Product number
B3929
Product name
3-Bromo-2-fluorobenzoic Acid
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$37
Updated
2025/07/31
TCI Chemical
Product number
B3929
Product name
3-Bromo-2-fluorobenzoic Acid
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$111
Updated
2025/07/31
TRC
Product number
B686025
Product name
3-Bromo-2-fluorobenzoic Acid
Packaging
100g
Price
$745
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0021197
Product name
3-BROMO-2-FLUOROBENZOIC ACID
Purity
95.00%
Packaging
25G
Price
$625
Updated
2021/12/16
SynQuest Laboratories
Product number
2621-B-32
Product name
3-Bromo-2-fluorobenzoic acid
Purity
98%
Packaging
100g
Price
$200
Updated
2021/12/16
More
Less

3-Bromo-2-fluorobenzoic acid Chemical Properties,Usage,Production

Chemical Properties

Off-white powder

Uses

3-Bromo-2-fluorobenzoic acid is used as a reagent to synthesize Dabrafenib, an inhibitor of BRAF kinase that is used to treat BRAF V600-mutation positive carcinoma. BRAF is a gene that mediates cell growth and is activated by mutations caused by cancer. 3-Bromo-2-fluorobenzoic acid is also used as a reagent to prepare Alkynlphenoxyacetic acid receptor agonists, compounds that can be potentially used for the treatment of allergic inflammatory diseases (such as allergic rhinitis).

Synthesis

1072-85-1

124-38-9

161957-56-8

1. n-Butyl lithium (n-BuLi, 240 mL of a 2.5 M solution, 600 mmol) was added dropwise to a tetrahydrofuran (THF, 500 mL) solution of diisopropylamine (84.3 mL, 600 mmol) at -30°C. 2. The resulting solution was stirred at -30°C for 30 minutes. 3. The mixture was added dropwise to a solution of 1-bromo-2-fluorobenzene (100 g, 571.43 mmol) in THF (500 mL) at -78° C. The solution was stirred for 30 minutes at -78° C. The mixture was then added to a solution of 1-bromo-2-fluorobenzene (100 g, 571.43 mmol). 4. After the addition, the resulting solution was stirred at -78°C for 2 hours. 5. The reaction mixture was poured over crushed solid carbon dioxide. 6. After removal of the solvent in vacuo, the resulting residue was diluted with water and washed with ether (2 x 500 mL). 7. The aqueous phase was acidified to pH 2 with 1N hydrochloric acid (HCl). 8. The precipitate was collected by filtration and dried to give 3-bromo-2-fluorobenzoic acid (90 g, 64% yield) as a white solid. 9. Mass spectrometry (MS) analysis showed m/z 221.0 (M + H+).

References

[1] Bulletin de la Societe Chimique de France, 1996, vol. 133, # 2, p. 133 - 141
[2] Patent: WO2011/119704, 2011, A1. Location in patent: Page/Page column 39-40
[3] Bioorganic and Medicinal Chemistry, 2006, vol. 14, # 12, p. 4158 - 4181
[4] Patent: US2009/203657, 2009, A1. Location in patent: Page/Page column 47
[5] Patent: US2009/203677, 2009, A1. Location in patent: Page/Page column 50

3-Bromo-2-fluorobenzoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

3-Bromo-2-fluorobenzoic acid Suppliers

Americas 1 CHINA 258 Europe 3 Germany 4 India 11 Italy 1 Japan 2 Poland 1 Slovakia 1 United Kingdom 12 United States 33 Global 327
Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
Country
United States
ProdList
10186
Advantage
62
Accela ChemBio Inc.
Tel
+1(858) 699-3322
Fax
+1(858) 876-1948
Email
marketing@accelachem.com
Country
United States
ProdList
6024
Advantage
65
AbaChemScene
Tel
732-484-9848
Fax
888-484-5008
Email
sales@chemscene.com
Country
United States
ProdList
3982
Advantage
60
Accela ChemBio Inc.
Tel
+1-858-6993322
Fax
(+1)-858-876-1948
Email
info@accelachem.com
Country
United States
ProdList
21193
Advantage
58
Alchem Pharmtech,Inc.
Tel
8485655694
Email
sales@alchempharmtech.com
Country
United States
ProdList
63687
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
Aceschem Inc.
Tel
+1-817863-6948 +1-（817）863-6948
Email
sales@aceschem.com
Country
United States
ProdList
19632
Advantage
58
Synthonix Inc
Tel
--
Fax
--
Email
info@synthonix.com
Country
United States
ProdList
6872
Advantage
58
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6962
Advantage
56
SynQuest Laboratories, Inc.
Tel
--
Fax
--
Email
info@synquestlabs.com
Country
United States
ProdList
6871
Advantage
62
TCI America
Tel
--
Fax
--
Email
sales@tciamerica.com
Country
United States
ProdList
6909
Advantage
75
Frontier Scientific, Inc.
Tel
--
Fax
--
Email
sales@frontiersci.com
Country
United States
ProdList
6222
Advantage
86
Matrix Scientific
Tel
--
Fax
--
Email
sales@matrixscientific.com
Country
United States
ProdList
6632
Advantage
80
AlliChem, LLC
Tel
--
Fax
--
Email
sales@allichemllc.com
Country
United States
ProdList
6516
Advantage
60
AOBChem USA
Tel
--
Fax
--
Email
sales@aobchem.com
Country
United States
ProdList
3487
Advantage
50
Wilshire Chemical Company Inc.
Tel
--
Fax
--
Email
WilshrChem@AOL.COM
Country
United States
ProdList
3498
Advantage
58
Combi-Blocks Inc.
Tel
--
Fax
--
Email
sales@combi-blocks.com
Country
United States
ProdList
6618
Advantage
69
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87
Oakwood Products, Inc.
Tel
--
Fax
--
Email
sales@oakwoodchemical.com
Country
United States
ProdList
6193
Advantage
74
Alfa Aesar
Tel
--
Fax
--
Email
tech@alfa.com
Country
United States
ProdList
6814
Advantage
81
INDOFINE Chemical Company, Inc.
Tel
--
Fax
--
Email
chemical@indofinechemical.com
Country
United States
ProdList
6176
Advantage
69
Focus Synthesis LLC
Tel
--
Fax
--
Email
acd@focussynthesis.com
Country
United States
ProdList
2487
Advantage
61
Waterstone Technology, LLC
Tel
--
Fax
--
Email
sales@waterstonetech.com
Country
United States
ProdList
6786
Advantage
30
2A PharmaChem USA
Tel
--
Fax
--
Email
sales@2apharmachem.com
Country
United States
ProdList
6137
Advantage
39
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6718
Advantage
47
AK Scientific, Inc.
Tel
--
Fax
--
Email
sales@aksci.com
Country
United States
ProdList
6347
Advantage
65
APAC Pharmaceutical, LLC
Tel
--
Fax
--
Email
sales@apacpharma.com
Country
United States
ProdList
6322
Advantage
38
American Custom Chemicals Corporation
Tel
--
Fax
--
Email
sales@acccorporation.com
Country
United States
ProdList
6820
Advantage
51
ChemPacific Corporation
Tel
--
Fax
--
Email
sales@chempacific.com
Country
United States
ProdList
6891
Advantage
51
BOSCHE SCIENTIFIC, LLC
Tel
--
Fax
--
Email
Sales@BoscheSci.com
Country
United States
ProdList
6477
Advantage
55
AcceleDev Chemical LLC
Tel
--
Fax
--
Email
info@acceledev.com
Country
United States
ProdList
632
Advantage
42
ASDI Incorporated
Tel
--
Fax
--
Email
customerservice@asdi.net
Country
United States
ProdList
6922
Advantage
67
Beta Pharma, Inc.
Tel
--
Fax
--
Email
sales@betapharma.com
Country
United States
ProdList
6226
Advantage
60
More
Less

View Lastest Price from 3-Bromo-2-fluorobenzoic acid manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
3-Bromo-2-fluorobenzoic acid 161957-56-8
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 mt
Release date
2024-12-03
Shaanxi Dideu Medichem Co. Ltd
Product
3-Bromo-2-fluorobenzoic acid 161957-56-8
Price
US $0.10/KG
Min. Order
0.1KG
Purity
99%HPLC
Supply Ability
200TONS
Release date
2019-12-24
Shaanxi Dideu Medichem Co. Ltd
Product
2-Chloro-6-fluorobenzoic acid 434-75-3
Price
US $0.10/KG
Min. Order
0.1KG
Purity
97%HPLC
Supply Ability
200TONS
Release date
2019-12-24

161957-56-8, 3-Bromo-2-fluorobenzoic acidRelated Search:

Ethyl 2-(Chlorosulfonyl)acetate 4-Bromofluorobenzene 1,3-Difluorobenzene Folic acid 2-Fluorobenzoic acid Florfenicol Transfluthrin 4-Bromomethylbenzoic acid 3,5-Dimethylbenzoic acid 3-Bromo-2-fluoroanisole Citric acid Ascoric Acid 3-BROMO-5-HYDROXYBENZOIC ACID 3-Bromo-6-chloroimidazo[1,2-b]pyridazine 3-BROMO-2-FLUOROBENZOTRIFLUORIDE 3-BROMO-5-ISOXAZOLECARBOXALDEHYDE 3-Bromo-5-iodo-pyridine 3-Bromo-4-chlorofuro[3,2-c]pyridine

  • 3-Bromo-2-fluorobenzoic acid 97%
  • Benzoic acid, 3-bromo-2-fluoro-
  • BUTTPARK 14\01-30
  • 3-BROMO-2-FLUOROBENZOIC ACID
  • 3-Bromo-2-fluorobenzoic
  • 3-Bromo-2-fluorobenzoic acid 97%+
  • 3-Bromo-2-fluorobenzoic Acid &gt
  • 2-fluoro-3-bromobenzoic acid,3-Bromo-2-fluoro-benzoic acid,3-Bromo-2-Fluorobenzoic acid
  • 3-Bromo-2-fluorobenzoic acid,98%
  • 161957-56-8
  • C7H4BrFO2
  • C7H4BrF2
  • Carboxylic acid
  • Benzoic acid
  • API intermediates
  • Acids and Derivatives
  • Halides
  • Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts