BOC-4-IODO-L-PHENYLALANINE

Product Name: BOC-4-IODO-L-PHENYLALANINE
CAS No.: 62129-44-6
Chemical Name: BOC-4-IODO-L-PHENYLALANINE
Synonyms: BOC-L-PHE(4-I);BOC-L-4-IODOPHE;BOC-PHE(4-1)-OH;BOC-PHE(4-I)-OH;BOC-PHE(P-I)-OH;BOC-PI-L-PHE-OH;BOC-4'-IODO-L-PHE;BOC-L-PHE(4-I)-OH;BOC-P-IODO-PHE-OH;BOC-4-IODO-PHE-OH
CBNumber: CB1672091
Molecular Formula: C14H18INO4
Formula Weight: 391.2
MOL File: 62129-44-6.mol

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BOC-4-IODO-L-PHENYLALANINE Property

Melting point:: ~150 °C (dec.)
alpha: 22.5 º (c=1% in ethyl acetate)
Boiling point:: 475.3±40.0 °C(Predicted)
Density: 1.560±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form: Powder
pka: 3.84±0.10(Predicted)
Appearance: White to off-white Solid
optical activity: [α]20/D +22.5±3°, c = 1% in ethyl acetate
Water Solubility: Slightly soluble in water.
Sensitive: Light Sensitive
BRN: 4503851
InChI: InChI=1S/C14H18INO4/c1-14(2,3)20-13(19)16-11(12(17)18)8-9-4-6-10(15)7-5-9/h4-7,11H,8H2,1-3H3,(H,16,19)(H,17,18)/t11-/m0/s1
InChIKey: JZLZDBGQWRBTHN-NSHDSACASA-N
SMILES: C(O)(=O)[C@H](CC1=CC=C(I)C=C1)NC(OC(C)(C)C)=O
CAS DataBase Reference: 62129-44-6(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
WGK Germany: 3
F: 8
HazardClass: IRRITANT
HS Code: 2922498590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 15346
Product name: Boc-Phe(4-I)-OH
Purity: ≥99.0% (TLC)
Packaging: 5g
Price: $143
Updated: 2025/07/31

TCI Chemical

Product number: B6605
Product name: Boc-Phe(4-I)-OH
Packaging: 1G
Price: $38
Updated: 2025/07/31

TCI Chemical

Product number: B6605
Product name: Boc-Phe(4-I)-OH
Packaging: 5G
Price: $114
Updated: 2025/07/31

Usbiological

Product number: 262048
Product name: Boc-4-iodo-L-phenylalanine
Packaging: 10g
Price: $470
Updated: 2021/12/16

TRC

Product number: B656695
Product name: Boc-4-iodo-L-phenylalanine
Packaging: 50g
Price: $495
Updated: 2021/12/16

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BOC-4-IODO-L-PHENYLALANINE Chemical Properties,Usage,Production

Chemical Properties

White powder

Uses

N-Boc-4-iodo-L-phenylalanine is used as pharmaceutical intermediate. It is also used as a p-iodo phenyl alanine derivative with N-Boc protection.

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

24424-99-5

1991-81-7

103882-09-3

The reaction was carried out as follows: a 3L three-neck flask was used. (S)-4-Iodo-L-phenylalanine (200.00 g, 687.10 mmol, 1.00 eq.), 1,4-dioxane (1.00 L) and water (1.00 L) were added sequentially to the reaction flask, followed by the addition of sodium hydroxide (68.71 g, 1.72 mol, 2.50 eq.), which led to a gradual clarification of the solution and a slight increase in temperature to 19 °C. The reaction was carried out using a three-necked flask. After the system was cooled to 0-10 °C, di-tert-butyl dicarbonate (254.93 g, 1.17 mol, 268.35 mL, 1.70 eq.) was added slowly dropwise and the reaction temperature was naturally increased to 10-30 °C. The reaction was then carried out at room temperature with the addition of sodium hydroxide (68.71 g, 1.72 mol, 2.50 eq.). After addition, the reaction system was stirred at room temperature (about 30 °C) for 8 hours. The reaction process was monitored by high performance liquid chromatography (HPLC) until the feedstock was fully converted. Subsequently, the temperature of the system was controlled to be below 40 °C and concentrated under reduced pressure to remove 1,4-dioxane. After the reaction mixture was cooled to room temperature (about 25 °C), the reaction was quenched by the addition of 100 mL of water and the pH was adjusted to 1.8-2.0 with 2 M hydrochloric acid. the resulting mixture was extracted three times with ethyl acetate (2 L x 3). The organic phases were combined, washed twice sequentially with saturated brine (1L×2), dried with anhydrous sodium sulfate (200 g), and concentrated under reduced pressure to give a light yellow solid crude product. The crude product was dried in an oven at 40-45 °C to obtain white solid (S)-N-Boc-4-iodo-L-phenylalanine (250.00 g, 626.28 mmol, 93.00% yield, 98% HPLC purity). The structure of the product was confirmed by 1H NMR (400 MHz, DMSO-d6): δ 7.49 (d, J = 7.8 Hz, 2H), 6.88 (d, J = 7.8 Hz, 2H), 5.80 (d, J = 5.9 Hz, 1H), 3.68 (d, J = 5.5 Hz, 1H), 3.00-2.90 (m, 1H), 2.87- 2.75 (m, 1H), 1.35-1.15 (m, 9H).

References

[1] Patent: US2018/155368, 2018, A1. Location in patent: Paragraph 0090-0096
[2] Journal of the American Chemical Society, 2012, vol. 134, # 2, p. 800 - 803
[3] Chemistry - A European Journal, 2013, vol. 19, # 22, p. 7020 - 7041
[4] Journal of Organic Chemistry, 2018, vol. 83, # 8, p. 4525 - 4536
[5] Journal of Organic Chemistry, 1998, vol. 63, # 22, p. 8019 - 8020

BOC-4-IODO-L-PHENYLALANINE Preparation Products And Raw materials

Raw materials

Preparation Products

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BOC-4-IODO-L-PHENYLALANINE Suppliers

China 212 Europe 2 France 2 Germany 6 India 3 Japan 3 Switzerland 2 United Kingdom 10 United States 36 Global 276

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ABCR GmbH & CO. KG

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View Lastest Price from BOC-4-IODO-L-PHENYLALANINE manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: BOC-4-IODO-L-PHENYLALANINE 62129-44-6
Price: US $0.00-0.00/kG
Min. Order: 1kG
Purity: 99%
Supply Ability: 1000G
Release date: 2025-09-24

Career Henan Chemical Co

Product: BOC-D-4-IODOPHENYLALANINE 62129-44-6
Price: US $20.00/KG
Min. Order: 10KG
Purity: 98%
Supply Ability: 100kg
Release date: 2018-07-31

62129-44-6, BOC-4-IODO-L-PHENYLALANINERelated Search:

TERT-BUTYL 4-(BENZYLAMINO)-3-FLUOROPIPERIDINE-1-CARBOXYLATE TERT-BUTYL 4-AMINO-3-FLUOROPIPERIDINE-1-CARBOXYLATE BOC-SAR-OH Boc-N-beta-Trityl-L-asparagine N-tert-Butoxycarbonyl-L-glutamic acid gamma-tert-butyl ester Boc-L-aspartic acid 4-tert-butyl ester Boc-6-AMinocaproic acid BOC-NLE-OH DCHA Succinimido (S)-2-[(tert-butoxycarbonyl)amino]propionate Boc-L-glutamic acid 5-cyclohexyl ester Boc-D-aspartic acid 4-benzyl ester BOC-GLU(OFM)-OH BOC-PHE-SER-ARG-AMC ACETATE SALT BOC-ORN-OH N-Boc-L-alaninol N-Boc-L-Phenylalaninol 4-Iodotoluene 4-IODO-D-PHENYLALANINE

N-ALPHA-T-BUTYLOXYCARBONYL-L-4-IODOPHENYLALANINE

N-alpha-t-Butyloxycarbonyl-4-iodo-L-phenylalanine

BOC-P-IODO-PHENYLALANINE

BOC-P-IODO-PHE-OH

BOC-L-PHE(4-I)

BOC-L-PHE(4-I)-OH

BOC-L-4-IODOLPHENYLALANINE

BOC-L-4-IODOPHE

BOC-L-4-IODOPHENYLALANINE

BOC-4'-IODO-L-PHE

BOC-4-IODO-L-PHENYLALANINE

BOC-4-IODO PHENYLALANINE

BOC-4-IODO-PHE-OH

(S)-N-ALPHA-T-BUTYLOXYCARBONYL-4-IODOPHENYLALANINE

RARECHEM BK PT 0164

(S)-2-(TERT-BUTOXYCARBONYLAMINO)-3-(4-IODOPHENYL)PROPANOIC ACID

N-TBOC-P-IODO-L-PHENYLALANINE

N-ALPHA-T-BUTOXYCARBONYL-4-IODEO-L-PHENYLALANINE

N-ALPHA-T-BUTOXYCARBONYL-P-IODO-L-PHENYLALANINE

N-ALPHA-TERT-BUTYLOXYCARBONYL-L-4-IODOPHENYLALANINE

Boc-4-lodo-Phe-OH

Boc-4-Lodo-L-Phenylalanine

4-Iodo-L-phenylalanine, N-BOC protected

(Tert-Butoxy)Carbonyl Phe(4-I)-OH

4-Iodo-L-phenylalanine, N-BOC protected 98%

N-(tert-butoxycarbonyl)-p-iodo-L-phenylalanine

Boc-L-4-Iodo-phe-OH

(2S)-2-[(tert-Butoxycarbonyl)amino]-3-(4-iodophenyl)propanoic acid

N-(Tert-Butoxycarbonyl)-4-iodo-(L)-phenylalanine

N-Boc-4-Iodo-L-phenylalanine (Boc-Phe(4-I)-OH) ,99% (HPLC)

Boc-L-Phe(4-I) –OH Boc-4-Iodo-L-Phenylalanine

Boc-4-iodo-L-phenylalanine Boc-p-iodo-L-Phe-OH

N-(tert-butyloxycarbonyl)-3-(4-iodophenyl)alanine

(2S)-2-[(tert-Butoxycarbonyl)amino]-3-(4-iodophenyl)propanoic acid, N-(tert-Butoxycarbonyl)-4-iodo-L-phenylalanine

L-N-(tert-Butoxycarbonyl)-4-iodophenylalanine

Boc-Phe(4-I)-OH >=99.0% (TLC)

BOC-S-PHE(4-I)-OH

BOC-(S)-2-AMINO-3-(4'-IODOPHENYL)PROPANOIC ACID

BOC-PHE(4-1)-OH

BOC-PHE(4-I)-OH

BOC-PHE(P-I)-OH

BOC-PI-L-PHE-OH

BOC-P-IODO-L-PHENYLALANINE

BOC-P-IODO-L-PHE-OH

(S)-Boc-2-amino-3-(4-iodophenyl)propionic acid

Boc-4-iodo-L-phenylalanine≥ 98% (HPLC)

(2S)-3-(4-iodophenyl)-2-[[(2-methylpropan-2-yl)oxy-oxomethyl]amino]propanoic acid

L-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-4-iodo-

BOC-4-IODO-L-PHENYLALANINE USP/EP/BP

(2S)-3-(4-iodophenyl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid

Fampridine Impurity 26 (3-Aminopyridin-4-ol)

62129-44-6

CH33COCONHCHCOOHCH2C6H4I

C14H18IHO4

Specialty Synthesis

Unnatural Amino Acid Derivatives

Phenylalanine Derivatives

Peptide Synthesis