N-Benzyloxycarbonyl-L-asparagine

Product Name: N-Benzyloxycarbonyl-L-asparagine
CAS No.: 2304-96-3
Chemical Name: N-Benzyloxycarbonyl-L-asparagine
Synonyms: CBZ-L-ASPARAGINE;Z-ASN-OH;CBZ-L-ASN;CBZ-ASN-OH;CBZ-L-ASN-OH;Z-ASN;Z-L-ASN-OH;Z-Asn-OH 99%;Z-ASPARAGINE;CBZ asparagine
CBNumber: CB1677773
Molecular Formula: C12H14N2O5
Formula Weight: 266.25
MOL File: 2304-96-3.mol

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N-Benzyloxycarbonyl-L-asparagine Property

Melting point:: 163-165 °C(lit.)
alpha: 6.5 º (c=2, CH3COOH)
Boiling point:: 409.45°C (rough estimate)
Density: 1.2846 (rough estimate)
refractive index: 6.3 ° (C=1.6, AcOH)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: almost transparency in hot Methanol
form: powder to crystal
pka: 3.77±0.10(Predicted)
color: White to Almost white
optical activity: [α]20/D +6°, c = 1.6 in acetic acid
BRN: 3085452
InChIKey: FUCKRCGERFLLHP-VIFPVBQESA-N
CAS DataBase Reference: 2304-96-3(CAS DataBase Reference)
EPA Substance Registry System: L-Asparagine, N2-[(phenylmethoxy)carbonyl]- (2304-96-3)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 20/21/22-36/37/38
Safety Statements: 24/25-36-26
WGK Germany: 3
TSCA: Yes
HazardClass: IRRITANT
HS Code: 29242990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C6404
Product name: Z-Asn-OH
Purity: 99%
Packaging: 10g
Price: $108
Updated: 2023/06/20

TCI Chemical

Product number: C0573
Product name: Nalpha-Carbobenzoxy-L-asparagine
Purity: >99.0%(T)
Packaging: 1g
Price: $32
Updated: 2025/07/31

TCI Chemical

Product number: C0573
Product name: Nalpha-Carbobenzoxy-L-asparagine
Purity: >99.0%(T)
Packaging: 10g
Price: $77
Updated: 2025/07/31

Usbiological

Product number: 461082
Product name: Nα-Cbz-L-asparagine
Packaging: 25g
Price: $403
Updated: 2021/12/16

TRC

Product number: C227305
Product name: Nα-Cbz-L-asparagine
Packaging: 250g
Price: $725
Updated: 2021/12/16

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N-Benzyloxycarbonyl-L-asparagine Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powde

Uses

Nα-Cbz-L-asparagine is an N-Cbz-protected form of L-Asparagine (A790005). L-Asparagine was first isolated by Robiquet and Vauquelin from asparagus juice (a high source of L-asparagine). L-Asparagine is often incorporated into proteins, and is a basis for some cancer therapies as certain cancerous cells require L-asparagine for growth.

Synthesis

70-47-3

501-53-1

2304-96-3

At 0 °C, 6.05 g (45 mmol) of L-asparagine was dissolved in 100 mL of 10% Na2CO3 aqueous solution, followed by the addition of 56 mL of 1,4-dioxane and 6.9 mL (40 mmol) of benzyl chloroformate. The reaction mixture was stirred overnight at room temperature and poured into 300 mL of water. The aqueous phase was extracted three times with ether. The aqueous phase was acidified with 2N HCl aqueous solution until a white precipitate precipitated. The precipitate was collected by filtration and washed well with ether to give Cbz-L-asparagine (Compound 14) as an off-white solid (9 g, 84% yield); Mass Spectra (ESI): m/z = 267 [M + H]+, 289 [M + Na]+.

References

[1] Tetrahedron Asymmetry, 2015, vol. 26, # 21-22, p. 1273 - 1280
[2] Tetrahedron, 2000, vol. 56, # 16, p. 2513 - 2522
[3] Tetrahedron Letters, 2015, vol. 56, # 26, p. 3999 - 4001
[4] European Journal of Organic Chemistry, 2014, vol. 2014, # 31, p. 7015 - 7022
[5] Chemical Communications, 2016, vol. 52, # 60, p. 9438 - 9441

N-Benzyloxycarbonyl-L-asparagine Preparation Products And Raw materials

Raw materials

Preparation Products

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N-Benzyloxycarbonyl-L-asparagine Suppliers

Americas 1 Belgium 2 China 318 Europe 3 France 2 Germany 6 Hungary 1 India 26 Japan 6 South Korea 1 Switzerland 6 United Kingdom 13 United States 59 Global 444

Acros Organics

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Email: info@acros.com
Country: Belgium
ProdList: 6772
Advantage: 81

Maybridge Chemical Co., Ltd.

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ProdList: 6293
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View Lastest Price from N-Benzyloxycarbonyl-L-asparagine manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: N-Benzyloxycarbonyl-L-asparagine 2304-96-3
Price: US $0.00/Kg/Drum
Min. Order: 1KG
Purity: 98%min
Supply Ability: 500kgs
Release date: 2021-09-26

Hebei Chuanghai Biotechnology Co., Ltd

Product: N-Benzyloxycarbonyl-L-asparagine 2304-96-3
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-14

Henan Aochuang Chemical Co.,Ltd.

Product: N-Benzyloxycarbonyl-L-asparagine 2304-96-3
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-12

2304-96-3, N-Benzyloxycarbonyl-L-asparagineRelated Search:

Diethylstilbestrol Glycine CARBONYL SULFIDE Trimethoprim PYRAZOPHOS 1,1'-Carbonyldiimidazole D-(-)-Asparagine monohydrate L-Asparagine ASPARAGINASE tert-Butyl carbazate N-Carbobenzyloxyglycine 6-Aminocaproic acid FMOC-ASN(TRT)-OPFP Z-ASN-ONP Z-ASP-OME N-Cbz-L-Aspartic acid 4-tert-butyl ester Z-ASN(TRT)-OH Z-ARG(NO2)-OH

n2-[(phenylmethoxy)carbonyl]-l-asparagin

L-Asparagine, N-CBZ protected

N-α-Z-L-asparagine

N(a)-Benzyloxycarbonyl-L-asparagine

N-A-CBZ-L-ASPARAGINE CRYSTALLINE

N2-[(PHENYLMEHTOXY)CARBONYL]-L-ASPARAGINE

CBZ-L-Asparagine-OH

N(alpha)-Benzyloxycarbonyl-L-asparagine~Z-Asn-OH

N-Carbobenzyloxy-L-asparagine

N-CBZ-L-Asparagine N-Carbobenzyloxy-L-asparagine

n(à)-benzyloxycarbonyl-l-asparagine

n(à)-cbz-l-asparagine

Z-ASN

(S)-N-(BENZYLOXYCARBONYL)ASPARAGINE

4-Amino-2-{[(benzyloxy)carbonyl]amino}-4-oxobutanoic acid

L-N-Cbz-Asparagine

N<sup>α</sup>-Carbobenzyloxy-L-asparagine

Z-L-AspaD23-RAgine

Nalpha-Carbobenzoxy-L-asparagine , 99.0%(T)

Z-Asn-OH 99%

4-amino-4-oxo-2-[[oxo-(phenylmethoxy)methyl]amino]butanoic acid

Asparagine, N(2)-carboxy-, N(2)-benzyl ester, L-

Asparagine, N-(benzyloxy)carbonyl-

Carbobenzoxy-L-asparagin

Carbobenzoxy-L-asparagine

CBZ asparagine

Nα-Z-L-asparagine≥ 99% (HPLC)

N-CBZ-L-ASN-OH

Z-ASPARAGINE

Z-ASN-OH

Z-L-ASPARAGINE

Z-L-ASN-OH

N-CBZ-L-ASPARAGINE

N-CBZ-L-ASPARAGINE-OH

CBZ-ASN-OH

CBZ-L-ASN-OH

N(ɑ)-Benzyloxycarbonyl-L-asparagine, 98+%

N2-[(PHENYLMETHOXY)CARBONYL]-L-ASPARAGINE

N-ALPHA-BENZYLOXYCARBONYL-L-ASPARAGINE

N-BENZYLOXYCARBONYL-L-ASPARAGINE

N-CARBOBENZOXY-L-ASPARAGINE

N(ALPHA)-CBZ-L-ASPARAGINE

N-ALPHA-CARBOBENZYLOXY-L-ASPARAGINE

NALPHA-CARBOBENZOXY-L-ASPARAGINE

(S)-2-BENZYLOXYCARBONYLAMINO-SUCCINAMIC ACID

CBZ-L-ASN

CBZ-L-ASPARAGINE

CARBOBENZYLOXY-L-ASPARAGINE

BENZYLOXYCARBONYL-L-ASPARAGINE

N2-(Benzyloxycarbonyl)-L-asparagine

N2-[(Benzyloxy)carbonyl]-L-asparagine

N2-Benzyloxycarbonyl-L-asparagine

N(^a)-Benzyloxycarbonyl-L-asparagine, 98+%

Nalpha-Carbobenzyloxy-L-asparagine,98%

N(alpha)-Benzyloxycarbonyl-L-asparagine, 98+%

Z-L-ASPARGINE extrapure

(2S)-4-Amino-4-oxo-2-(phenylmethoxycarbonylamino)butanoic acid

L-Asparagine, N(2)-[(phenylmethoxy)carbonyl]-