Synephrine hydrochloride

Product Name: Synephrine hydrochloride
CAS No.: 5985-28-4
Chemical Name: Synephrine hydrochloride
Synonyms: SYNEPHRINE HCL;JACS-5985-28-4;UNII-EN5D1IH09S;Synephrine HCl 98%min;N-METHYL OCTOPAMINE HCL;Sympathol hydrochloride;Synephrine hydrochlorid;SYNEPHRINE HYDROCHLORIDE;Synephrine/Synephrine Hcl;(±)-Oxedrine hydrochloride
CBNumber: CB1690109
Molecular Formula: C9H14ClNO2
Formula Weight: 203.67
MOL File: 5985-28-4.mol

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Synephrine hydrochloride Property

Melting point:: 147-150°C
storage temp.: Refrigerator
solubility: Methanol (Slightly), Water (Slightly)
form: Solid
color: Off-White to Pale Beige
InChI: InChI=1S/C9H13NO2.ClH/c1-10-6-9(12)7-2-4-8(11)5-3-7;/h2-5,9-12H,6H2,1H3;1H
InChIKey: COTCEGYSNTWJQV-UHFFFAOYSA-N
SMILES: C1(=CC=C(O)C=C1)C(O)CNC.Cl
LogP: -0.030 (est)
CAS DataBase Reference: 5985-28-4(CAS DataBase Reference)

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Safety

HS Code: 2922498590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 28398
Product name: (±)-Synephrine (hydrochloride)
Packaging: 10g
Price: $95
Updated: 2024/03/01

Cayman Chemical

Product number: 28398
Product name: (±)-Synephrine (hydrochloride)
Packaging: 50g
Price: $220
Updated: 2024/03/01

Cayman Chemical

Product number: 28398
Product name: (±)-Synephrine (hydrochloride)
Packaging: 5g
Price: $57
Updated: 2024/03/01

Cayman Chemical

Product number: 28398
Product name: (±)-Synephrine (hydrochloride)
Packaging: 25g
Price: $152
Updated: 2024/03/01

TRC

Product number: S920001
Product name: rac-SynephrineHydrochloride
Packaging: 100g
Price: $410
Updated: 2021/12/16

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Synephrine hydrochloride Chemical Properties,Usage,Production

Description

(±)-Synephrine is an alkaloid with vasoconstrictor and metabolic activities. It binds to α_1A-, α_2A-, and α_2C-adrenergic receptors (ARs; K_is = 78, 36.7, and 24.4 μM, respectively). (±)-Synephrine is an agonist of α_1A-ARs in HEK293 cells (EC₅₀ = 4 μM in a reporter assay) but not in CHO cells expressing α_2A- or α_2C-AR. It also acts as an antagonist of α_1A-, α_2A-, and α_2C-ARs, inhibiting L-phenylephrine-induced activation of α_1A-AR in HEK293 cells and activation of α_2A- and α_2C-ARs induced by the α₂-AR agonist medetomidine in CHO cells (IC₅₀s = 12.8, 26, and 27.3 μM, respectively, in reporter assays). (±)-Synephrine induces contractions in isolated rabbit aortic rings (EC₅₀ = 6.2 μg/ml) and increases ligation-induced mean arterial pressure in rats when administered at a dose of 2 mg/kg per day. It induces lipolysis in isolated rat and human adipocytes when used at concentrations of 100 and 1,000 μg/ml. (±)-Synephrine (50 μM) increases phosphorylation of Akt and AMP-activated protein kinase (AMPK) and translocation of Glut4 to the plasma membrane, as well as increases insulin-induced glucose consumption in L6 muscle cells when used at concentrations ranging from 25 to 200 μM.

Chemical Properties

Pale Beige Solid

Uses

A α-adrenergic receptor agonist, vasoconstrictor.

References

[1] YI-TSAU HUANG . Fructus aurantii reduced portal pressure in portal hypertensive rats[J]. Life sciences, 1995, 57 22: Pages 2011-2020. DOI: 10.1016/0024-3205(95)02195-o
[2] JOSEP MERCADER. Isopropylnorsynephrine is a stronger lipolytic agent in human adipocytes than synephrine and other amines present in Citrus aurantium.[J]. Journal of physiology and biochemistry, 2011, 67 3: 443-452. DOI: 10.1007/s13105-011-0078-2
[3] NA-YOUNG HONG. p-Synephrine stimulates glucose consumption via AMPK in L6 skeletal muscle cells[J]. Biochemical and biophysical research communications, 2012, 418 4: Pages 720-724. DOI: 10.1016/j.bbrc.2012.01.085
[4] GUOYI MA. Effects of synephrine and beta-phenethylamine on human alpha-adrenoceptor subtypes.[J]. Planta medica, 2010, 76 10: 981-986. DOI: 10.1055/s-0029-1240884
[5] J A BEVAN J V O. Relative sensitivity of some large blood vessels of the rabbit to sympathomimetic amines.[J]. Journal of Pharmacology and Experimental Therapeutics, 1965, 150 3: 370-374.

Synephrine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Synephrine hydrochloride Suppliers

Canada 1 China 339 China Hong Kong 1 Germany 1 India 2 United Kingdom 5 United States 33 Global 382

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View Lastest Price from Synephrine hydrochloride manufacturers

Lianyungang Kaiyu Environmental Tech Co., Ltd.

Product: Synephrine 5985-28-4
Price: US $1200.00-1100.00/ton
Min. Order: 1ton
Purity: 99%
Supply Ability: 1000T/M
Release date: 2025-11-05

Lianyungang Kaiyu Environmental Tech Co., Ltd.

Product: Synephrine 5985-28-4
Price: US $1200.00-1100.00/ton
Min. Order: 1ton
Purity: 99%
Supply Ability: 1000T/M
Release date: 2025-09-30

Jinan Ruitong Biotech Co., Ltd.

Product: Synephrine hydrochloride 5985-28-4
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1
Release date: 2025-08-20

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JACS-5985-28-4

Synephrine hydrochloride, 98%, an α-adrenergic and -adrenergic agonist derived from the Citrus aurantium, it has sympathomimetic and structural similarities to ephedra and ephedrine alkaloids

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C9H14NO2Cl

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5985-28-4