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Synephrine hydrochloride

Product Name
Synephrine hydrochloride
CAS No.
5985-28-4
Chemical Name
Synephrine hydrochloride
Synonyms
SYNEPHRINE HCL;JACS-5985-28-4;UNII-EN5D1IH09S;Synephrine HCl 98%min;N-METHYL OCTOPAMINE HCL;Sympathol hydrochloride;Synephrine hydrochlorid;SYNEPHRINE HYDROCHLORIDE;Synephrine/Synephrine Hcl;(±)-Oxedrine hydrochloride
CBNumber
CB1690109
Molecular Formula
C9H14ClNO2
Formula Weight
203.67
MOL File
5985-28-4.mol
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Synephrine hydrochloride Property

Melting point:
147-150°C
storage temp. 
Refrigerator
solubility 
Methanol (Slightly), Water (Slightly)
form 
Solid
color 
Off-White to Pale Beige
InChI
InChI=1S/C9H13NO2.ClH/c1-10-6-9(12)7-2-4-8(11)5-3-7;/h2-5,9-12H,6H2,1H3;1H
InChIKey
COTCEGYSNTWJQV-UHFFFAOYSA-N
SMILES
C1(=CC=C(O)C=C1)C(O)CNC.Cl
LogP
-0.030 (est)
CAS DataBase Reference
5985-28-4(CAS DataBase Reference)
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Safety

HS Code 
2922498590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
28398
Product name
(±)-Synephrine (hydrochloride)
Packaging
10g
Price
$95
Updated
2024/03/01
Cayman Chemical
Product number
28398
Product name
(±)-Synephrine (hydrochloride)
Packaging
50g
Price
$220
Updated
2024/03/01
Cayman Chemical
Product number
28398
Product name
(±)-Synephrine (hydrochloride)
Packaging
5g
Price
$57
Updated
2024/03/01
Cayman Chemical
Product number
28398
Product name
(±)-Synephrine (hydrochloride)
Packaging
25g
Price
$152
Updated
2024/03/01
TRC
Product number
S920001
Product name
rac-SynephrineHydrochloride
Packaging
100g
Price
$410
Updated
2021/12/16
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Synephrine hydrochloride Chemical Properties,Usage,Production

Description

(±)-Synephrine is an alkaloid with vasoconstrictor and metabolic activities. It binds to α1A-, α2A-, and α2C-adrenergic receptors (ARs; Kis = 78, 36.7, and 24.4 μM, respectively). (±)-Synephrine is an agonist of α1A-ARs in HEK293 cells (EC50 = 4 μM in a reporter assay) but not in CHO cells expressing α2A- or α2C-AR. It also acts as an antagonist of α1A-, α2A-, and α2C-ARs, inhibiting L-phenylephrine-induced activation of α1A-AR in HEK293 cells and activation of α2A- and α2C-ARs induced by the α2-AR agonist medetomidine in CHO cells (IC50s = 12.8, 26, and 27.3 μM, respectively, in reporter assays). (±)-Synephrine induces contractions in isolated rabbit aortic rings (EC50 = 6.2 μg/ml) and increases ligation-induced mean arterial pressure in rats when administered at a dose of 2 mg/kg per day. It induces lipolysis in isolated rat and human adipocytes when used at concentrations of 100 and 1,000 μg/ml. (±)-Synephrine (50 μM) increases phosphorylation of Akt and AMP-activated protein kinase (AMPK) and translocation of Glut4 to the plasma membrane, as well as increases insulin-induced glucose consumption in L6 muscle cells when used at concentrations ranging from 25 to 200 μM.

Chemical Properties

Pale Beige Solid

Uses

A α-adrenergic receptor agonist, vasoconstrictor.

Synephrine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Synephrine hydrochloride Suppliers

J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6005
Advantage
61
TAIYUAN RHF CO.,LTD.
Tel
+86 351 7031519
Fax
+86 351 7031519
Email
sales@RHFChem.com
Country
China
ProdList
2338
Advantage
56
ShangHai DEMO Chemical Co.,Ltd
Tel
400-021-7337 2355568890
Fax
0086-21-50182339
Email
sales@demochem.com
Country
China
ProdList
2572
Advantage
57
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Email
sales@capotchem.com
Country
China
ProdList
18207
Advantage
66
Beijing Ouhe Technology Co., Ltd
Tel
010-82967028 13552068683
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12438
Advantage
60
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14103
Advantage
59
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
19172
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42958
Advantage
64
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View Lastest Price from Synephrine hydrochloride manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Synephrine HCl 5985-28-4
Price
US $120.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-04-24
BINBO BIOLOGICAL CO.,LTD
Product
Synephrine hydrochloride 5985-28-4
Price
US $0.00/kg
Min. Order
1kg
Purity
99.8%
Supply Ability
1000 kg
Release date
2024-04-12
Hebei Yanxi Chemical Co., Ltd.
Product
Synephrine hydrochloride 5985-28-4
Price
US $0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20 tons
Release date
2023-10-07

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