Synephrine hydrochloride
- Product Name
- Synephrine hydrochloride
- CAS No.
- 5985-28-4
- Chemical Name
- Synephrine hydrochloride
- Synonyms
- SYNEPHRINE HCL;JACS-5985-28-4;UNII-EN5D1IH09S;Synephrine HCl 98%min;N-METHYL OCTOPAMINE HCL;Sympathol hydrochloride;Synephrine hydrochlorid;SYNEPHRINE HYDROCHLORIDE;Synephrine/Synephrine Hcl;(±)-Oxedrine hydrochloride
- CBNumber
- CB1690109
- Molecular Formula
- C9H14ClNO2
- Formula Weight
- 203.67
- MOL File
- 5985-28-4.mol
Synephrine hydrochloride Property
- Melting point:
- 147-150°C
- storage temp.
- Refrigerator
- solubility
- Methanol (Slightly), Water (Slightly)
- form
- Solid
- color
- Off-White to Pale Beige
- InChI
- InChI=1S/C9H13NO2.ClH/c1-10-6-9(12)7-2-4-8(11)5-3-7;/h2-5,9-12H,6H2,1H3;1H
- InChIKey
- COTCEGYSNTWJQV-UHFFFAOYSA-N
- SMILES
- C1(=CC=C(O)C=C1)C(O)CNC.Cl
- LogP
- -0.030 (est)
- CAS DataBase Reference
- 5985-28-4(CAS DataBase Reference)
Safety
- HS Code
- 2922498590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- 28398
- Product name
- (±)-Synephrine (hydrochloride)
- Packaging
- 10g
- Price
- $95
- Updated
- 2024/03/01
- Product number
- 28398
- Product name
- (±)-Synephrine (hydrochloride)
- Packaging
- 50g
- Price
- $220
- Updated
- 2024/03/01
- Product number
- 28398
- Product name
- (±)-Synephrine (hydrochloride)
- Packaging
- 5g
- Price
- $57
- Updated
- 2024/03/01
- Product number
- 28398
- Product name
- (±)-Synephrine (hydrochloride)
- Packaging
- 25g
- Price
- $152
- Updated
- 2024/03/01
- Product number
- S920001
- Product name
- rac-SynephrineHydrochloride
- Packaging
- 100g
- Price
- $410
- Updated
- 2021/12/16
Synephrine hydrochloride Chemical Properties,Usage,Production
Description
(±)-Synephrine is an alkaloid with vasoconstrictor and metabolic activities. It binds to α1A-, α2A-, and α2C-adrenergic receptors (ARs; Kis = 78, 36.7, and 24.4 μM, respectively). (±)-Synephrine is an agonist of α1A-ARs in HEK293 cells (EC50 = 4 μM in a reporter assay) but not in CHO cells expressing α2A- or α2C-AR. It also acts as an antagonist of α1A-, α2A-, and α2C-ARs, inhibiting L-phenylephrine-induced activation of α1A-AR in HEK293 cells and activation of α2A- and α2C-ARs induced by the α2-AR agonist medetomidine in CHO cells (IC50s = 12.8, 26, and 27.3 μM, respectively, in reporter assays). (±)-Synephrine induces contractions in isolated rabbit aortic rings (EC50 = 6.2 μg/ml) and increases ligation-induced mean arterial pressure in rats when administered at a dose of 2 mg/kg per day. It induces lipolysis in isolated rat and human adipocytes when used at concentrations of 100 and 1,000 μg/ml. (±)-Synephrine (50 μM) increases phosphorylation of Akt and AMP-activated protein kinase (AMPK) and translocation of Glut4 to the plasma membrane, as well as increases insulin-induced glucose consumption in L6 muscle cells when used at concentrations ranging from 25 to 200 μM.
Chemical Properties
Pale Beige Solid
Uses
A α-adrenergic receptor agonist, vasoconstrictor.
Synephrine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Synephrine hydrochloride manufacturers
- Product
- Synephrine HCl 5985-28-4
- Price
- US $120.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20ton
- Release date
- 2024-04-24
- Product
- Synephrine hydrochloride 5985-28-4
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99.8%
- Supply Ability
- 1000 kg
- Release date
- 2024-04-12
- Product
- Synephrine hydrochloride 5985-28-4
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 20 tons
- Release date
- 2023-10-07