ChemicalBook > CAS DataBase List > DROXIDOPA

DROXIDOPA

Product Name: DROXIDOPA
CAS No.: 23651-95-8
Chemical Name: DROXIDOPA
Synonyms: L-threo-3,4-Dihydroxyphenylserine;Droxidopa (JAN);l-dops;SM 5688;roxidopa;DROXIDOPA;Droxydopa;l-threodops;Droxidopa>Droxidopa-13C6
CBNumber: CB1699324
Molecular Formula: C9H11NO5
Formula Weight: 213.19
MOL File: 23651-95-8.mol

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DROXIDOPA Property

Melting point:: 232-235° (dec); mp 229-232° (dec) (Ohashi)
alpha: D20 -39° (c = 1 in 1N aq HCl); D20 -42.0° (c = 1 in 1N aq HCl)
Boiling point:: 549.8±50.0 °C(Predicted)
Density: 1.608±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: DMSO: ≥3mg/mL
form: powder
pka: 2.09±0.24(Predicted)
color: white to tan
Merck: 14,3457
Stability:: Hygroscopic
InChI: InChI=1/C9H11NO5/c10-7(9(14)15)8(13)4-1-2-5(11)6(12)3-4/h1-3,7-8,11-13H,10H2,(H,14,15)/t7-,8+/s3
InChIKey: QXWYKJLNLSIPIN-WWXSATIUNA-N
SMILES: [C@H](C1C=CC(O)=C(O)C=1)(O)[C@H](N)C(=O)O |&1:0,10,r|
CAS DataBase Reference: 23651-95-8

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26
WGK Germany: 3
RTECS: VT9626010
HS Code: 29225090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: D9446
Product name: L-DOPS
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $151
Updated: 2025/07/31

Sigma-Aldrich

Product number: D9446
Product name: L-DOPS
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $599
Updated: 2025/07/31

TCI Chemical

Product number: D4235
Product name: Droxidopa
Purity: >98.0%(HPLC)(T)
Packaging: 50mg
Price: $160
Updated: 2025/07/31

TCI Chemical

Product number: D4235
Product name: Droxidopa
Purity: >98.0%(HPLC)(T)
Packaging: 200mg
Price: $456
Updated: 2025/07/31

Cayman Chemical

Product number: 23779
Product name: Droxidopa
Purity: ≥95%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

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DROXIDOPA Chemical Properties,Usage,Production

Description

Droxidopa is a synthetic amino acid precursor of (-)-norepinephrine which is absorbed from the gut and metabolized to norepinephrine. In Parkinsonian patients, droxidopa added to existing levodopa/decarboxylase inhibitor therapy produces significant improvements in retropulsion, dysarthria and muscular rigidity refractory to other treatments; however, tremor was unaffected.

Description

Droxidopa (L-DOPS) is a synthetic precursor and prodrug of the neurotransmitter norepinephrine. It is transformed into norepinephrine through the action of DOPA decarboxylase. L-DOPS increases norepinephrine levels in the rat heart following intraperitoneal administration and in the brain following intracerebroventricular administration at doses of 125 and 100 μg/animal, respectively. It increases arterial pressure and mesenteric arterial resistance in rats with ligated portal vein or biliary ducts when used at doses of 25-50 mg/kg. L-DOPS crosses the blood brain barrier, however, its effects can be blocked by the peripherally-restricted DOPA decarboxylase inhibitor carbidopa , indicating that the mechanism is peripheral. Formulations containing droxidopa are used in the treatment of neurogenic orthostatic hypotension.

Chemical Properties

Off-White Solid

Originator

Sumitomo (Japan)

Uses

The L-threo-form Droxidopa. A synthetic amino acid precursor of Norepinephrine (N674500). Antiparkinsonian.

Uses

Droxidopa is a psychoactive drug and acts as a prodrug to the neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline).

Uses

L-DOPS has been administered for clinical trial studies in mice with amyloid pathology.

Definition

ChEBI: A serine derivative that is L-serine substituted at the beta-position by a 3,4-dihydroxyphenyl group. A prodrug for noradrenalone, it is used for treatment of neurogenic orthostatic hypotension

brand name

DOPS

General Description

L-DOPS, also called L-threo 3,4-Dihydroxyphenylserine or droxidopa is a catecholamine. L-DOPS has many clinical advantages and may be useful for treating norepinephrine deficiency. It is used for treating neurogenic orthostatic hypotension and improves norepinephrine levels. L-DOPS mediates reduction of amyloid plaques and could have a therapeutic potential for treating amyloid pathology.

Biochem/physiol Actions

L-DOPS is a norepinephrine precursor in vivo.

References

[1] J BARTHOLINI. The stereoisomers of 3,4-dihydroxyphenylserine as precursors of norepinephrine.[J]. Journal of Pharmacology and Experimental Therapeutics, 1975, 193 2: 523-532.
[2] MAR COLL. Droxidopa, an oral norepinephrine precursor, improves hemodynamic and renal alterations of portal hypertensive rats??[J]. Hepatology, 2012, 56 5: 1849-1860. DOI: 10.1002/hep.25845
[3] HORACIO KAUFMANN Jose A P Lucy Norcliffe Kaufmann. Droxidopa in neurogenic orthostatic hypotension.[J]. Expert Review of Cardiovascular Therapy, 2015, 13 8: 875-891. DOI: 10.1586/14779072.2015.1057504

DROXIDOPA Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from DROXIDOPA manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: DROXIDOPA 23651-95-8
Price: US $1.00-4.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200000KG
Release date: 2025-09-11

Shaanxi Dideu New Materials Co. Ltd

Product: DROXIDOPA 23651-95-8
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-03-31

Hebei Chuanghai Biotechnology Co,.LTD

Product: DROXIDOPA 23651-95-8
Price: US $19.00/KG
Min. Order: 1KG
Purity: 99.%
Supply Ability: 50 ton
Release date: 2024-08-20

23651-95-8, DROXIDOPARelated Search:

Nitazoxanide VILAZODONE Miglitol alpha,2-Dimethyl-5-nitro-1H-imidazole-1-ethanol L-M-TYROSINE Levodopa 3-(3-Hydroxyphenyl)-DL-alanine 3-Phenyl-L-serine (2RS,3RS)-2-AMINO-3-(3,4-DIHYDROXY-PHENYL)-3-HYDROXY-PROPIONIC ACID Dihydrocaffeic acid Chrysene DROXIDOPA DL-THREO-3-PHENYLSERINE HYDRATE, 99 (S)-3-HYDROXY-3-PHENYLPROPANOIC ACID DL-THREO-3-PHENYLSERINE DL-BETA-PHENYLSERINE THREO FORM BOC-D-THREO-3-(BENZO[1,3]DIOXOL-5-YL)SERINE BOC-D-THREO-3-(3,4-DIMETHOXYPHENYL)SERINE

Droxidopa (JAN)

L-threo-3,4-Dihydroxyphenylserine

L-threo-b-(3,4-Dihydroxyphenyl)serine

L-Tyrosine, b,3-dihydroxy-, threo-

L-Tyrosine, β,3-dihydroxy-, (βR)-

Serine, 3-(3,4-dihydroxyphenyl)-, L-threo- (8CI)

SM 5688

threo-Dopaserine

(2S,3R)-2-Amino-3-(3,4-dihydroxyphenyl)-3-hydroxypropionic acid

(βR)-β,3-Dihydroxy-L-tyrosine

(-)-(2S,3R)-2-Amino-3-hydroxy-3-(3,4-dihydroxyphenyl)propionic acid

L-threo-Droxidopa

DROXIDOPA

Droxydopa

Droxidopa-13C6

(2S,3R)-2-aMino-3-(3,4-dihydroxyphenyl)-3-hydroxypropanoic acid

DROXIDOPA,SM 5688

L-Tyrosine, b,3-dihydroxy-, (bR)-

(2S,3R)-3-(3,4-Dihydroxyphenyl)-2-amino-3-hydroxypropanoic acid

Droxidopa impurity B

Droxidopa (L DOPS

SM5688; DROXIDOPA (L DOPS;SM 5688)

Droxidopa (L-DOPS,SM-5688)

(-)-(2s,3r)-2-amino-3-hydroxy-3-(3,4-dihydroxyphenyl)propionicacid

3-dihydroxy-bet(beta-r)-l-tyrosin

3-dihydroxy-betthreo-l-tyrosin

4-dihydroxyphenyl)-3-(l-threo-serin

l-dops

l-threo-3-(3,4-dihydroxyphenyl)serine

l-threodops

Droxidopa impurity A

Droxidopa&gt

DROXIDOPA USP/EP/BP

L-3,4-Dihydroxyphenylserine trifluoroacetate salt

L-3,4-Dihydroxyphenylserine

(2S,3R)-2-azaniumyl-3-(3,4-dihydroxyphenyl)-3-hydroxypropanoate

DroxidopaQ: What is Droxidopa Q: What is the CAS Number of Droxidopa Q: What is the storage condition of Droxidopa Q: What are the applications of Droxidopa

roxidopa

Droxidopa Reference Standard

Droxidopa, 10 mM in DMSO

23651-95-8

C9H11NO5

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