1H-1,2,4-Triazole-1-carboximidamide hydrochloride

Product Name: 1H-1,2,4-Triazole-1-carboximidamide hydrochloride
CAS No.: 19503-26-5
Chemical Name: 1H-1,2,4-Triazole-1-carboximidamide hydrochloride
Synonyms: 1H-1,2,4-triazole-1-carboxiMidaMide hydrochloride;NOLA-010;1H-1,2,4-TRI;TIMTEC-BB SBB004089;Methotrexate (Abitrexate);1-CARBAMIDINO-1,2,4-TRIAZOLE;1,2,4-triazole-1-carboximidamide;1H-1,2,4-Triazole-1-CarboxaMidine;1-AMIDINO-1,2,4-TRIAZOLE HYDROCHLORIDE;1H-1,2,4-triazole-1-carboximidamide HCl
CBNumber: CB1711419
Molecular Formula: C3H6ClN5
Formula Weight: 147.57
MOL File: 19503-26-5.mol

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1H-1,2,4-Triazole-1-carboximidamide hydrochloride Property

Melting point:: 215-220 °C
storage temp.: Inert atmosphere,Room Temperature
Water Solubility: Soluble in water
form: powder to crystal
color: White to Almost white
BRN: 9500271
InChI: InChI=1S/C3H5N5.ClH/c4-3(5)8-2-6-1-7-8;/h1-2H,(H3,4,5);1H
InChIKey: JDDXNENZFOOLTP-UHFFFAOYSA-N
SMILES: C(N1N=CN=C1)(N)=N.Cl
CAS DataBase Reference: 19503-26-5

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Safety

Hazard Codes: Xn
Risk Statements: 22-36-52/53-43
Safety Statements: 26-36/37-61
RIDADR: 2811
WGK Germany: 3
HazardClass: 6.1
PackingGroup: III
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TCI Chemical

Product number: T3124
Product name: 1,2,4-Triazole-1-carboximidamide Hydrochloride
Purity: >98.0%(T)
Packaging: 1g
Price: $16
Updated: 2024/03/01

TCI Chemical

Product number: T3124
Product name: 1,2,4-Triazole-1-carboximidamide Hydrochloride
Purity: >98.0%(T)
Packaging: 5g
Price: $42
Updated: 2024/03/01

Alfa Aesar

Product number: H60475
Product name: 1H-1,2,4-Triazole-1-carboxamidine hydrochloride, 98%
Packaging: 5g
Price: $18.65
Updated: 2024/03/01

Alfa Aesar

Product number: H60475
Product name: 1H-1,2,4-Triazole-1-carboxamidine hydrochloride, 98%
Packaging: 25g
Price: $79.2
Updated: 2024/03/01

TRC

Product number: T767418
Product name: 1H-1,2,4-Triazole-1-carboximidamideHydrochloride
Packaging: 100mg
Price: $75
Updated: 2021/12/16

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1H-1,2,4-Triazole-1-carboximidamide hydrochloride Chemical Properties,Usage,Production

Chemical Properties

White crystalline

Uses

[1,2,4]Triazole-1-carboxamidine is an intermediate used in the synthesis of peramivir (P285500), a neuraminidase inhibitor developed as an antiviral agent for the treatment of influenza.

Synthesis

1H-1,2,4-Triazole-1-carboxamidine hydrochloride is prepared by the reaction of dicyandiamide and 1,2,4-Triazole. The steps are as follows:
Dissolve the compound (19.7 g, 0.29 mol) in 20 ml of tetrahydrofuran, and the temperature was raised to 70℃. A solution of dicyandiamide (20 g, 0.24 mol) was added and a solution of 4 mol / L HCl in tetrahydrofuran 27 g, 0.26 mol) at 70℃ for 2 h, the temperature was removed and cooled to room temperature. The solid was removed by filtration and 26.0 g was removed by filtration. The solvent was dried in vacuo at 45℃ to give a colorless oil which was recrystallized from methanol: dichloromethane = 2: 1 Of the mixed solution 50ml recrystallization, cooling crystallization, suction filter to get 6.2g solid, drying a total of 30.1g white powder. Yield 90.3%, purity 99,8%.

1H-1,2,4-Triazole-1-carboximidamide hydrochloride Preparation Products And Raw materials

Raw materials

1,2,4-Triazole Ethanol Sodium chloride 1,4-Dioxane Hydrochloric acid Cyanamide Sulfuric acid

Preparation Products

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1H-1,2,4-Triazole-1-carboximidamide hydrochloride Suppliers

China 199 Germany 3 India 6 Japan 1 Switzerland 1 United States 13 Global 223

Alchem Pharmtech,Inc.

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TimTec Corporation

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View Lastest Price from 1H-1,2,4-Triazole-1-carboximidamide hydrochloride manufacturers

Jinan Jianfeng Chemical Co., Ltd

Product: 1H-1,2,4-Triazole-1-carboximidamide hydrochloride 19503-26-5
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%MIN
Supply Ability: 20TON
Release date: 2024-08-09

Jinan Jianfeng Chemical Co., Ltd

Product: 1H-1,2,4-Triazole-1-carboximidamide hydrochloride 19503-26-5
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%min
Supply Ability: 20ton
Release date: 2024-08-09

Henan Aochuang Chemical Co.,Ltd.

Product: 1H-1,2,4-TRIAZOLE-1-CARBOXAMIDINE MONOHYDROCHLORIDE 19503-26-5
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-30

19503-26-5, 1H-1,2,4-Triazole-1-carboximidamide hydrochlorideRelated Search:

SCH 58261 FLUQUINCONAZOLE MRS 1220 CGS 15943 ZM 241385 1H-1,2,4-Triazole-1-carboximidamide hydrochloride batelapine Bemitradine SALOR-INT L121010-1EA SALOR-INT L120995-1EA SALOR-INT L120987-1EA 3-(4-CHLOROPHENYL)-1-(8-IMINO-8,9-DIHYDRO-7H-[1,2,4]TRIAZOLO[1,5-D][1,2,4]TRIAZEPIN-5-YL)-5-(TRIFLUOROMETHYL)-4,5-DIHYDRO-1H-PYRAZOL-5-OL SALOR-INT L121002-1EA 1-(7-AMINO[1,2,4]TRIAZOLO[1,5-C]PYRIMIDIN-5-YL)-3-(4-CHLOROPHENYL)-5-(TRIFLUOROMETHYL)-4,5-DIHYDRO-1H-PYRAZOL-5-OL 1-(8-IMINO-8,9-DIHYDRO-7H-[1,2,4]TRIAZOLO[1,5-D][1,2,4]TRIAZEPIN-5-YL)-3-(2-METHOXYPHENYL)-5-(TRIFLUOROMETHYL)-4,5-DIHYDRO-1H-PYRAZOL-5-OL ZM 241385, [2-3H] 3,5-DIAMINO-1H-1,2,4-TRIAZOLE-1-CARBOXIMIDAMIDE HYDROCHLORIDE 4-FLUOROBENZALDEHYDE (8-IMINO-8,9-DIHYDRO-7H-[1,2,4]TRIAZOLO[1,5-D][1,2,4]TRIAZEPIN-5-YL)HYDRAZONE

1H-1,2,4-TRIAZOLE-1-CARBOXAMIDINE MONOHYDROCHLORIDE

1-CARBAMIDINO-1,2,4-TRIAZOLE

1H-1,2,4-Triazole-1-carboxamidine monohydrochloride ,98.5%

1-AMIDINO-1,2,4-TRIAZOLE HYDROCHLORIDE

TIMTEC-BB SBB004089

1h-1,2,4-triazole-1-carboxamidinehydrochloride

1H-1,2,4-TRIAZOLE-1-CARBOXAMIDINE MONOHY

(1H)-1,2,4-Triazole-1-carboxamidineHClpurum

(1H)-1,2,4-Triazole-1-carboxamidinemonohydrochloridepurum

1-amidino-1h-1,2,4-triazole hydrochloride

1H-1,2,4-TRIAZOLE-1-CARBOXAMIDINE MONOHY DROCHLORIDE PURUM 98+%

1H-1,2,4-triazole-1-carboxiMidaMide hydrochloride

1H-1,2,4-Triazole-1-CarboxaMidine

Methotrexate (Abitrexate)

1H-1,2,4-Triazole-1-carboxaMidine Monohydrochloride ,98%

[1,2,4]Triazole-1-carboxaMidine Hydrochloride

1,2,4-Triazole-1-carboximidamide Hydrochloride

1-Carbamimidoyl-1,2,4-triazole Hydrochloride

1H-1,2,4-Triazole-1-carboximidamide, hydrochloride (1:1)

1H-1,2,4-Triazole-1-carboxamidine hydrochloride≥ 98%(Titration)

1-Amidino-1,2,4-triazole monohydrochloride

NOLA-010

1H-1,2,4-TRI

TIANFU-CHEM - 1H-1,2,4-TRIAZOLE-1-CARBOXAMIDINE MONOHYDROCHLORIDE

1,2,4-triazole-1-carboximidamide

1H-1,2, 4-triazol-1-methylamidine monohydrochloride

1H-1,2,4-triazole-1-carboximidamide HCl

19503-26-5

C3H6ClN5

C3H5N5HCl

C3H5N5ClH

Guanidine Protection/Guanidinylation

Peptide Synthesis

Specialty Synthesis