ChemicalBook > CAS DataBase List > 6-Chloropurine
6-Chloropurine
- Product Name
- 6-Chloropurine
- CAS No.
- 87-42-3
- Chemical Name
- 6-Chloropurine
- Synonyms
- 6-CHLORO-9H-PURINE;ClP;6-CHLORO-7H-PURINE;6-CP;6-chloro-5H-purine;x47;X 47;nsc744;sk6048;NSC 744
- CBNumber
- CB1726169
- Molecular Formula
- C5H3ClN4
- Formula Weight
- 154.56
- MOL File
- 87-42-3.mol
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6-Chloropurine Property
- Melting point:
- >300 °C (dec.) (lit.)
- Boiling point:
- 254.17°C (rough estimate)
- Density
- 1.4649 (rough estimate)
- refractive index
- 1.8430 (estimate)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- 5 g/L
- form
- crystalline
- pka
- 7.47±0.20(Predicted)
- color
- yellow-orange
- Water Solubility
- 5 g/L
- Merck
- 14,2161
- BRN
- 5774
- InChIKey
- ZKBQDFAWXLTYKS-UHFFFAOYSA-N
- CAS DataBase Reference
- 87-42-3(CAS DataBase Reference)
- NIST Chemistry Reference
- 6-Chloropurine(87-42-3)
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Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 22-36/37/38-20/21/22
- Safety Statements
- 26-36-36/37/39
- WGK Germany
- 3
- RTECS
- UO7520000
- F
- 10-23
- HazardClass
- IRRITANT
- HS Code
- 29335990
- Toxicity
- LD50 oral in mouse: 720mg/kg
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P330Rinse mouth.
P501Dispose of contents/container to..…
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 161179
- Product name
- 6-Chloropurine
- Purity
- ≥99%
- Packaging
- 5g
- Price
- $68.8
- Updated
- 2024/03/01
TCI Chemical
- Product number
- C0278
- Product name
- 6-Chloropurine
- Purity
- >98.0%(T)
- Packaging
- 5g
- Price
- $73
- Updated
- 2024/03/01
TCI Chemical
- Product number
- C0278
- Product name
- 6-Chloropurine
- Purity
- >98.0%(T)
- Packaging
- 25g
- Price
- $161
- Updated
- 2024/03/01
Alfa Aesar
- Product number
- A11202
- Product name
- 6-Chloropurine, 99%
- Packaging
- 1g
- Price
- $25.65
- Updated
- 2024/03/01
Alfa Aesar
- Product number
- A11202
- Product name
- 6-Chloropurine, 99%
- Packaging
- 5g
- Price
- $73.65
- Updated
- 2024/03/01
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6-Chloropurine Chemical Properties,Usage,Production
Chemical Properties
It is a pale yellow crystal with relatively stable chemical properties that do not cause decomposition at room temperature. Its structure includes nitrogen heterocycles, which give rise to remarkable alkalinity and the formation of volatile acid salts. It is soluble in dimethyl sulfoxide, but has only slight solubility in water.
Uses
6-Chloropurine is used in the preparation of 9-alkylpurines through alkylation with various substituted alkyl halides in dimethyl sulfoxide. It is also used to prepare 6-succinoaminopurine.
Definition
ChEBI: 6-Chloro-1H-purine is a member of purines. It is metabolized to form 6-mercaptopurine and has been used as an antineoplastic.
Preparation
6-chloropurine is synthesized by reacting hypoxanthine with phosphoryl chloride in the presence of an unreactive base such as dimethyl aniline. It may likewise be formed by heating hypoxanthine under pressure with phosphoryl chloride as well as with a reagent prepared by adding water, preferably about by volume, to dry phosphoryl chloride.
US2832781A
Synthesis Reference(s)
Journal of the American Chemical Society, 78, p. 1928, 1956 DOI: 10.1021/ja01590a043
General Description
The acid-catalyzed reaction of 6-chloropurine with 3,4-di-O-acetyl-D-xylal has been investigated.
Purification Methods
6-Chloropurine crystallises from water. The UV in water at pH 1 has 264nm (log 3.94). [Beilstein 26 III/IV 1742.]
6-Chloropurine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-Chloropurine manufacturers
ShenZhen H&D Pharmaceutical Technology Co., LTD
- Product
- 6-chloro-9H-purine 87-42-3
- Price
- US $0.00/mg
- Min. Order
- 10mg
- Purity
- 0.98
- Supply Ability
- 10g
- Release date
- 2024-04-08
Henan Fengda Chemical Co., Ltd
- Product
- 6-Chloropurine 87-42-3
- Price
- US $122.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-01-11
Hebei Mojin Biotechnology Co., Ltd
- Product
- 6-Chloropurine 87-42-3
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2023-06-20
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